RESUMO
PURPOSE: To determine the effectiveness of intravitreous gas injection in the management and clearing of experimental vitreous hemorrhage. METHODS: A total of ten New Zealand white rabbits received an injection of 0.4 ml of autologous blood into the vitreous of the right eye. After 24 hours of the vitreous hemorrhage simulation, six eyes were randomly assigned for treatment with na intravitreous injection of 0.2 ml of 100% perfluoropropane gas (C3F8) (group A), while four eyes received a control injection of an equivalent volume of balanced salt solution (group B). The persistence of vitreous opacification, which was graded at pre-established time points during 32 days of follow-up, was evaluated on the basis of visibility of retinal details in each of the four quadrants. RESULTS: In the gas-treated group (A), a partial view of the retina in the four quadrants was possible at 15 days, while at 32 days, the vitreous cavity was completely free of blood in all eyes, allowing unobstructed observation of the fundus. No retinal details could be observed in the control group after 32 days of follow-up. CONCLUSIONS: Gas injection proved effective in the treatment of experimental vitreous hemorrhage. It was significantly better than the injection of balanced salt solution, according to criteria of extension, intensity, and clearing time. Its technical facility, lack of complications, and low cost encourage additional research into gas injection to add knowledge to this initial study and to clarify its potential usefulness to treat persistent vitreous hemorrhage as well as to elucidate some unique pathophysiology features of blood catabolism in the vitreous.
Assuntos
Meios de Contraste/uso terapêutico , Fluorocarbonos/uso terapêutico , Hemorragia Vítrea/terapia , Animais , Modelos Animais de Doenças , Seguimentos , Injeções/métodos , Coelhos , Distribuição Aleatória , Retina/efeitos dos fármacos , Corpo Vítreo , Hemorragia Vítrea/induzido quimicamente , Hemorragia Vítrea/veterináriaRESUMO
Buraco macular é uma entidade decorrente de várias patologias, podendo apresentar-se de diversas formas, com diferentes prognósticos e tratamentos. Através da análise dos 1030 prontuários de maculopatia doSetor de Retina e Vítreo do Departamento de Oftalmologia UNIFESP/EPM, levantamos todos os casos de buraco de mácula de 1980 a 1995. O buraco macular idiopático foi o mais frequente, com dezoito pacientes (66,6 por cento), predominando no sexo feminino com média de 64 anos de idade e bilateral em cinco casos (18 por cento). Com relaçäo ao buraco macular secundário ao edema macular cistóide, observamos que sete (87,5 por cento) dos pacientes eram do sexo feminino, sendo que facectomia, dois casos (37,5 por cento) e uveíte, um caso (28,6 por cento) ..