[THE CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF MALARIA CONCURRENT WITH OTHER INFECTIONS AND INVASIONS].

The present review considers malaria infection concurrent with different species of helminths, bacterial and viral infections, as well as mixed malaria pathogens in the subtropical and tropical countries of the world, causing the clinical picture and epidemiological situation to be different. Malaria co-infections with different pathogenic micro-organisms, such as HIV, tuberculosis, viral hepatitides, and others, affect almost one third of the planet's population. It is known that people who are at risk for malaria may be also at risk for other parasitic and infectious diseases, most commonly helminthisms.

[Human dirofilariasis: clinical and diagnostic signs and diagnostic methods].

The clinical and diagnostic signs caused by the tissue location and migration of adult Dirofilaria in the human body determine the use of different methods for the diagnosis of dirofilariasis. During their investigations, the authors modified polymerase chain reaction (PCR): they chose and synthesized primers and selected amplification regimens for them and obtained agarose gel bands that corresponded to PCR fragment length nucleotide sequences that were equal to 245 bp for D. (N.) repens and 656 bp for D. immitis. There was 100% agreement in the results of PCR and microscopic examination of sera from 32 dogs and 1 female patient with low parasitemia and in the blood nucleotide sequence characteristic of D. repens.

[The epidemiological features of visceral leishmaniasis, revealed on examination of children by polymerase chain reaction, in the Papsky District, Namangan Region, Uzbekistan].

Patients with visceral leishmaniasis (VL) have been registered in the Papsky District, Namangan Region, Uzbekistan, over the past 23 years. A total of 95 patients were notified in 1987 to 2009. In 2007-2008, a mass survey using the polymerase chain reaction (PCR) within the international INTAS project 05-100006-8043 was conducted in 5 population aggregates of the Papsky District, Namangan Region, Uzbekistan, where VL cases had been regularly registered in the last years. Bone marrow and venous and peripheral blood smears were used as a test material. A total of 234 samples, including 3 bone marrow biopsy specimens, 9 venous blood samples and 222 peripheral blood ones, were tested. All the samples were on the glass slides. Three groups were identified among the examinees. Group 1 consisted of 13 subjects who had been ill at different times. Group 2 comprised 27 children treated at hospital for various diagnoses. Group 3 (the largest one, n=190) included apparently healthy children. All the children of this group felt well and had no symptoms of any illnesses at the examination. In this group, 85 (44.7%) subjects were PCR-positive. Twenty-four (55.8%) of 43 children in the age group of 0-3 years were PCR-positive; the 4-7-year age group comprised 66 subjects and 33 (50%) of them were PCR-positive. Group over 7 years of age included 81 subjects; 45 (55.5%) were PCR-positive. The results of the mass survey with PCR, which covered the 5 population aggregates in the Papsky District, Namangan Region, Uzbekistan, suggest the epidemic activity of a synathropic focus of VL and make us look at many fixed notions of its epidemiology in new contexts.

[Human dirofilariasis: diagnosis and the pattern of pathogen-host relations].

Until recently, there has been no consensus of opinion as to that D.repens females can develop in the accidental host (man). The role of man is regarded as a biological dead end for Dirofilaria that are unable to develop the adult stage; human Dirofilaria migration is considered to be larval by the type of larva migrans. Studying these matters on a specific material of 140 cases of invasion by Dirofilaria that had been eliminated in patients in different seasons and the length of their bodies measured showed that the maximum number (51.4%) was mature females, 120 to 190 mm in size; 35.7 and 12.85% had a length of 70-115 and 40-65 mm, respectively, which corresponds to immature young and juvenile specimens. This suggests that Dirofilaria normally develop and achieve the adult stage in the accidental host. A correlation was found in the sizes of the body and the time of D. repens development. Thus, the human organism is not a biological dead end for Dirofllaria. The migration of adult Dirofilaria should be appraised as the imago-migrans phenomenon: As the particular diagnostic sign, it will aid a physician to establish a correct parasitiological diagnosis at the early stages of the disease. In recent years, there has been new evidence in the diagnosis of dirofilariasis that microfilaria have been detected in the skin tumor puncture specimen and blood of the patients. In this connection, it is conceivable that man may be an actual source of mosquito infection even in the presence and paucity of mature males and females.

[The first case of diagnosis of dirofilariasis from the microfilariae detected in the human subcutaneous tumor punctate]. / Pervyi sluchai diagnostiki dirofiliarioza po mikrofiliariiam, obnaruzhennym v punktate podkozhnoi opukholi cheloveka.

The paper describes the first case of diagnosis of dirofilariasis from the microfilariae detected in the subcutaneous tumor punctate from a person who has the clinical manifestations of D. repens invasion and resides in the Saratov Region that is endemic in dirofilariasis. The fact of detection of microfilariae in the man undergone invasion is assessed not only as the first case in the lifetime diagnosis of the first case of diagnosis of subcutaneous dirofilariasis, but also as the first case of verification of that a female can achieve sexual maturity in the organism of an accidental host and its impregnation if there are even single specimens of both sexes, which is characteristic in human invasiveness. On this basis, the authors consider it wrong to refer this helminthiasis to as a group of diseases defined as "Larva migrans cutaneous" since this is inconsistent with the biology of a causative agent that accomplishes migration at the adult stage in the host's organism and does not orient a physician to establish a correct clinical and parasitological diagnosis.

[Experience in surgical treatment of injuries of the major vessels]. / Opyt khirurgicheskogo lecheniia povrezhdenii magistral'nykh sosudov.

Eighty-one patients were treated for injuries to the main vessels. They underwent operations at the Novgorod Regional Hospital and in surgical departments of the Novgorod Region. The injuries of the vessels were open in 90.1% and closed in 9.9% of patients. Among 125 reconstructive operations good results with restoration of arterial and venous blood flow and maintained function of the limb were produced in 67.9% and satisfactory results in 9.9% of patients. Amputation of the limb was carried out in 13 patients (16.0%). Mortality was 7.4% (six patients). The authors emphasize that early admission of patients to the hospital and the therapeutic tactics in a vascular trauma guarantee preservation of the injured limb, restoration of its function, and save the patient's life.