RESUMO
RATIONALE: Chronic low-grade inflammation is proposed as the keystone in pathogenesis of metabolic syndrome. The inflammatory biomarker Procalcitonin which is produced by adipose tissue, can serve as a biomarker for insulin resistant state present in metabolic syndrome. OBJECTIVES: To evaluate the association of plasma Procalcitonin (PCT) with components of metabolic syndrome (abdominal obesity, dyslipidemia, hypertension, and hyperglycemia) and with insulin resistance as compared to healthy controls. DESIGN: In this case-control study Plasma Procalcitonin was measured in patients with metabolic syndrome and compared to healthy controls. Its association was investigated with insulin resistance, individual components of metabolic syndrome, cardiovascular complications and microalbuminuria. RESULTS: Plasma Procalcitonin was significantly higher (mean 0.55 ± 0.60 ng/ ml, Median 0.156 ng/ml) in 53 patients with metabolic syndrome (n = 53) as compared to 26 healthy controls (p < 0.001). PCT significantly correlated with level of Insulin Resistance (p< 0.01), Waist Circumference, S. Triglycerides, S. VLDL (p < 0.05), fasting blood glucose (p < 0.01) and inversely with S.HDL (p< 0.05). PCT was significantly higher in patients with cardiovascular complication (n=16/53, z = -7.137) and in those with microalbuminuria (n=18/53, z = - 7.265) as compared to cases without complications. CONCLUSION: Raised plasma procalcitonin levels in the normal range are associated with insulin resistance and components of the metabolic syndrome (abdominal obesity, hypertriglyceridemia, high VLDL, low HDL and hyperglycemia), suggesting its role as a promising biomarker.
Assuntos
Biomarcadores/sangue , Resistência à Insulina/fisiologia , Síndrome Metabólica/sangue , Pró-Calcitonina/sangue , Glicemia , Índice de Massa Corporal , Estudos de Casos e Controles , Humanos , Índia , ObesidadeRESUMO
Vesicular mole is best regarded as a benign neoplasia of the chorion with malignant potentials. In India, the prevalence is one in four hundred pregnancies. We present one such case who presented with thyrotoxicosis and pulmonary edema.
Assuntos
Mola Hidatiforme/complicações , Síndrome do Desconforto Respiratório/etiologia , Tireotoxicose/etiologia , Neoplasias Uterinas/complicações , Adulto , Feminino , Humanos , Mola Hidatiforme/epidemiologia , Índia/epidemiologia , Gravidez , Prevalência , Neoplasias Uterinas/epidemiologiaRESUMO
A case of a 21 years male patient with type 3 glycogen storage disorder diagnosed at necropsy, who died suddenly with hypovolemic shock following a massive upper gastrointestinal bleeding due to hepatocellular failure is reported. Salient features of GSD type 3 are briefly discussed.
Assuntos
Hemorragia Gastrointestinal/patologia , Doença de Depósito de Glicogênio Tipo III/patologia , Falência Hepática Aguda/patologia , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Adulto , Autopsia , Biópsia por Agulha , Terapia Combinada , Progressão da Doença , Evolução Fatal , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/terapia , Doença de Depósito de Glicogênio Tipo III/complicações , Doença de Depósito de Glicogênio Tipo III/terapia , Humanos , Imuno-Histoquímica , Índia , Falência Hepática Aguda/etiologia , Falência Hepática Aguda/terapia , Masculino , Índice de Gravidade de DoençaRESUMO
We report four cases of neuroleptic malignant syndrome occurring after administration of a typical antipsychotic haloperidol and a newer atypical antipsychotic clozapine. The management of these patients is discussed.