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1.
Hip Int ; 29(4): 412-417, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30729802

RESUMO

BACKGROUND: The direct anterior approach to the hip joint enables the identification and ligation of the lateral circumflex femoral artery. However, the effect of lateral circumflex femoral artery ligation on blood flow to the muscles surrounding the hip remains unknown. This study clarified the changes in blood flow to the surrounding muscles following ascending branch ligation of this artery. METHODS: We included 36 consecutive patients (8 male and 28 female) who underwent total hip arthroplasty via the direct anterior approach for hip osteoarthritis between April 2015 and July 2016. The intraoperative blood flow to the tensor fascia latae (TFL), vastus lateralis (VL), rectus femoris (RF), and subcutaneous tissue (control) was measured using a laser Doppler blood flow meter. Measurements were repeated after artery ligation and at the end of surgery. We compared the means (±SD) of these measurements at each location and time point. RESULTS: The patients' mean age was 64.2 ± 9.0 years, systolic and diastolic blood pressures were 92.8 ± 13.6 and 54.9 ± 9.1 mmHg, respectively, and body mass index was 23.1 ± 3.9 kg/m2. Hypertension was noted in 35.9% patients and dyslipidemia in 27.8%. The mean surgical duration was 101 (70-158) min. The preligation blood flow in TFL, VL, RF, and subcutaneous tissue was 3.91 ± 1.93, 5.15 ± 2.19, 4.51 ± 2.24, and 3.03 ± 0.99 mL/min/100 g, respectively. CONCLUSIONS: Blood flow to TFL significantly decreased post ligation and at the end of surgery. However, there was no change in blood flow to VL and RF.


Assuntos
Artroplastia de Quadril , Artéria Femoral , Articulação do Quadril , Adulto , Idoso , Feminino , Artéria Femoral/cirurgia , Articulação do Quadril/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/cirurgia , Músculo Quadríceps , Coxa da Perna
2.
JB JS Open Access ; 3(2): e0048, 2018 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-30280134

RESUMO

BACKGROUND: Patients with acetabular dysplasia often have abnormal femoral and acetabular version. The effect of combined femoral and acetabular version on clinical outcomes after periacetabular osteotomy for the treatment of acetabular dysplasia remains unclear. The purposes of the present study were (1) to evaluate the association of combined femoral and acetabular version with clinical outcome after periacetabular osteotomy and (2) to investigate the association of femoral version independently with clinical outcome after periacetabular osteotomy. METHODS: We retrospectively reviewed the records for 92 consecutive patients (95 hips) who had undergone periacetabular osteotomy for the treatment of symptomatic acetabular dysplasia. The patient cohort comprised 85 females and 7 males with a mean age of 38.9 years at the time of surgery. The mean duration of follow-up was 4.8 years (range, 2.0 to 7.2 years). Femoral and acetabular version and the alpha angle were measured on postoperative computed tomography scans. Clinical outcomes included range of motion and the modified Harris hip score. Analysis of variance was used to investigate the effect of femoral version on clinical outcomes. Analysis of covariance was used to adjust for potential covariates. RESULTS: Combined femoral and acetabular version after periacetabular osteotomy was slightly, but significantly, correlated with postoperative flexion (r = 0.222; p = 0.031) and internal rotation in flexion (r = 0.326; p = 0.001). Patients with mild femoral version (<15°) experienced significantly less postoperative internal rotation in flexion than those with severe femoral version (>35°); however, this difference was lost after adjustment for potential covariates. There were no differences among femoral version groups (mild, moderate, and severe) in terms of improvements in the clinical outcomes of pain, function, and activity. CONCLUSIONS: Combined femoral and acetabular version after periacetabular osteotomy was significantly correlated with postoperative range of motion. Abnormality of femoral version associated with acetabular dysplasia did not demonstrate any effect on the clinical outcomes of periacetabular osteotomy. LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

3.
Int Orthop ; 42(6): 1253-1258, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29209742

RESUMO

PURPOSE: Curved periacetabular osteotomy (CPO) has been developed for the treatment of acetabular dysplasia. While several studies have reported its good clinical results, the complications of CPO include delayed union and nonunion of the superior pubic ramus. The purpose of this study is to investigate the prevalence of delayed union of the pubis one year after CPO, and to determine the risk factors for this complication. METHODS: The study examined 113 hips that underwent CPO between 2008 and 2012. Delayed union was assessed based on the anteroposterior radiography one year after CPO. A superior pubic ramus union group (U group) and a delayed union group (D group) were retrospectively compared regarding patient characteristics, clinical evaluations, and radiographic parameters. RESULTS: Delayed union rate was 16.8%. The D group contained a significantly greater proportion of smokers (p < 0.001). The gap at the pubic osteotomy site on CT coronal images was significantly larger in the D group (p < 0.001), and the cut-off value for the risk of nonunion was larger than 5.1 mm. Multivariate regression analysis indicated that smoking (OR 10.7, 95% CI 2.1-55.4) and a gap at the superior pubic ramus >5.1 mm (OR 16.5, 95% CI 3.7-73.7) were significantly associated with delayed union as independent risk factors. CONCLUSION: The prevalence of delayed union one year after CPO was 16.8%. Smoking and a gap larger than 5.1 mm at the pubic osteotomy site are risk factors for delayed union after CPO.


Assuntos
Acetábulo/cirurgia , Luxação Congênita de Quadril/cirurgia , Osteotomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Osso Púbico/fisiopatologia , Adolescente , Adulto , Idoso , Feminino , Articulação do Quadril/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Osteotomia/métodos , Complicações Pós-Operatórias/epidemiologia , Prevalência , Osso Púbico/diagnóstico por imagem , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
4.
J Orthop Sci ; 22(3): 531-535, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28254156

RESUMO

BACKGROUND: Curved periacetabular osteotomy (CPO) is one of the joint preserving procedures for developmental dysplasia of the hip. CPO requires osteotomy of the medial wall of the acetabulum, which may cause narrowing of the bony birth canal and this step may result in increased risk of cesarean delivery. We analyzed the narrowest part of the bony birth canal using three-dimensional computed tomography (3D-CT) before and after bilateral CPO. METHODS: Between February 2007 and March 2014, there were 29 cases of bilateral CPO in which both pre- and post-operative 3D-CT were available. Transverse diameters of the pelvic inlet, contraction, outlet, expansion, and teardrop were analyzed. Among them, the narrowest part of the bony birth canal was investigated, which being smaller than the normal lower threshold value for vaginal delivery (95 mm) was considered as a risk for cesarean delivery. RESULTS: The transverse diameters of both pelvic expansion and teardrop significantly decreased after CPO (both p < 0.01), while other diameters showed no significant changes. Among these two diameters, the narrowest diameter of the bony birth canal was the pelvic teardrop in all 29 cases. That in 24 patients (82.8%) was greater than 95 mm, while that in five patients (17.2%) showed less than 95 mm. CONCLUSIONS: Based on 3D-CT analysis, the narrowest part of the bony birth canal after bilateral CPO was the pelvic teardrop. In this study, 82.8% of the patients showed pelvic teardrop diameter greater than 95 mm, while that of the other patients (17.2%) were less than 95 mm.


Assuntos
Acetábulo/cirurgia , Imageamento Tridimensional , Osteotomia/métodos , Tomografia Computadorizada por Raios X/métodos , Acetábulo/diagnóstico por imagem , Adolescente , Adulto , Feminino , Luxação Congênita de Quadril/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Estudos Retrospectivos , Adulto Jovem
5.
Int Orthop ; 41(2): 253-258, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26893219

RESUMO

PURPOSE: Although most case of dislocations after total hip arthroplasty (THA) can be managed with conservative treatment, recurrent dislocation may require surgical intervention. This multicentre study was conducted to evaluate the re-dislocation rate after revision THA for recurrent dislocation, and to determine the risk factors for re-dislocation. METHODS: We retrospectively reviewed the 88 hips in 88 patients who underwent revision THA for recurrent dislocation at five institutions between 1995 and 2014. The mean patient age at surgery was 68.5 years and the mean follow-up period was 53.1 months. Multivariate logistic regression was performed to identify risk factors for re-dislocation. RESULTS: Sixteen hips in 16 patients (18.2 %) re-dislocated at a mean of 25.5 months (range, 1-83 months) after revision THA. Multivariate analysis identified osteonecrosis of the femoral head (odds ratio [OR] = 5.62 vs. osteoarthritis) and a femoral head size < 32 mm (OR = 3.86) as independent risk factors for re-dislocation. Eight hips required additional revision THA for re-dislocation. CONCLUSION: The re-dislocation rate after revision THA for recurrent dislocation remains high, suggesting the need for prevention measures. We recommend the use of a femoral head size ≥ 32 mm.


Assuntos
Artroplastia de Quadril/efeitos adversos , Articulação do Quadril/cirurgia , Luxações Articulares/cirurgia , Reoperação/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Luxações Articulares/epidemiologia , Masculino , Pessoa de Meia-Idade , Falha de Prótese , Estudos Retrospectivos , Fatores de Risco
6.
J Orthop Surg Res ; 11(1): 116, 2016 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-27751174

RESUMO

BACKGROUND: The vascular supply to the acetabular labrum is important in the treatment of labral lesions. However, in vivo blood flow measurements in the acetabular labrum have not been described in the literature. The purpose of this study was to examine this blood flow in vivo using laser Doppler flowmetry (LDF) in patients with acetabular dysplasia. METHODS: Periacetabular osteotomy combined with arthroscopy was performed in 47 consecutive patients (three males, 44 females; mean age at surgery, 35.6 years; range, 15-60 years). In all patients, blood flow in the acetabular labrum was measured with LDF during arthroscopy. The acetabular labral lesions were categorized according to the modified Beck classification: detachment and full-thickness labral tears were assigned to the T group and normal labrum to the N group. Blood flow rates in the acetabular labrum were compared between the T and N groups. The associations between labral blood flow and the lateral center-edge angle (CEa) and patient age were also evaluated. RESULTS: The T and N groups comprised 31 and 16 patients, respectively. The mean blood flow rate was 1.94 ± 0.41 ml/min/100 g in the T group and 1.94 ± 0.34 ml/min/100 g in the N group, with no significant difference between the groups (P = 0.884). No association was noted between blood flow and either the CEa or patient age (ß = -0.018, P = 0.077 and ß = -0.001, P = 0.770, respectively). CONCLUSIONS: On LDF, blood flow in the acetabular labrum was present in all patients, regardless of the severity of acetabular labral tears, CEa, or age.


Assuntos
Acetábulo/irrigação sanguínea , Cartilagem Articular/irrigação sanguínea , Luxação Congênita de Quadril/cirurgia , Acetábulo/cirurgia , Adolescente , Adulto , Artroscopia/métodos , Cartilagem Articular/lesões , Cartilagem Articular/cirurgia , Feminino , Humanos , Cuidados Intraoperatórios/métodos , Fluxometria por Laser-Doppler/métodos , Masculino , Pessoa de Meia-Idade , Osteotomia/métodos , Fluxo Sanguíneo Regional , Adulto Jovem
7.
J Arthroplasty ; 31(12): 2805-2809, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27369299

RESUMO

BACKGROUND: Although there were many clinical studies of highly cross-linked polyethylene (XLPE) wear among different femoral head diameters, few referred to thickness of XLPE in case larger femoral heads were used because smaller sockets were frequently used for Asian population. METHODS: This prospective study included 240 hips that underwent primary total hip arthroplasty using XLPE combined with 26-mm (group S) or 32-mm (group L) cobalt-chromium head with maximum follow-up of 10 years. We measured 3-dimensional (3-D) linear penetration rate of XLPE among same implant design groups except head diameter and estimated the validity of thinner XLPE. RESULTS: Our study demonstrated comparable 3-D linear penetration rates, which were 0.06 ± 0.07 mm/y for group S and 0.03 ± 0.02 mm/y for group L at 10 years after surgery and penetration rates seemed to be almost constant with no significant difference after 3 years. Minimum liner thickness (5.3 mm for 48-mm socket in combination with 32-mm femoral head) and the second thinnest XLPE (6.3 mm in case of socket from 50 mm to 54 mm combined with 32-mm femoral head) was distributed in 25% and 72% with group L, respectively, and there were no significant differences in penetration rates between 5.3-mm- and 6.3-mm-thickness groups. CONCLUSION: Our study suggested that whether to select 26- or 32-mm diameters of femoral head does not affect XLPE wear in combination with this type of articulation.


Assuntos
Artroplastia de Quadril/instrumentação , Prótese de Quadril/estatística & dados numéricos , Polietileno/análise , Idoso , Povo Asiático , Cromo , Cobalto , Feminino , Cabeça do Fêmur , Articulação do Quadril/diagnóstico por imagem , Humanos , Articulações , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Desenho de Prótese , Falha de Prótese , Radiografia
8.
J Am Podiatr Med Assoc ; 106(3): 229-34, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-27269979

RESUMO

Morton's neuroma is a common condition that mainly affects middle-aged women, and many articles have addressed the surgical treatment of this condition. Previous reports have described bilateral neuroma excision in women but not in men. We report a rare case of bilateral neuromas in a male patient treated with simultaneous neurectomy.


Assuntos
Neuroma Intermetatársico/cirurgia , Nervo Tibial/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neuroma Intermetatársico/diagnóstico por imagem , Neuroma Intermetatársico/patologia , Procedimentos Neurocirúrgicos
9.
Oncol Lett ; 11(4): 2875-2878, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27073568

RESUMO

Ordinary lipoma is cytogenetically characterized by structural rearrangements, particularly translocations, of 12q13-15. By contrast, atypical lipomatous tumors exhibit supernumerary ring or giant marker chromosomes that are composed mainly of amplified material from the 12q13-15 chromosome segment. The present study describes the cytogenetic and molecular cytogenetic findings from a lipomatous tumor with minimal nuclear atypia that was identified in a 49-year-old female patient. Magnetic resonance imaging of the right shoulder revealed a 13-cm fatty mass in the subcutaneous layer that possessed only pencil-line septa. Contrast-enhanced fat-suppressed T1-weighted images demonstrated faint enhancement. A marginal excision was performed. Histologically, the tumor was composed of lobules that consisted of mature adipocytes separated by thin fibrous septa. There was minimal nuclear atypia in certain cells, and a small number of binucleated cells were also observed within the tumor. Immunohistochemically, the tumor cells did not reveal the expression of murine double-minute 2 (MDM2). Cytogenetic analysis revealed a complex karyotype with several numerical and structural alterations, including 12q rearrangements. Spectral karyotyping demonstrated a duplication of chromosome segment 12q13-15. Interphase fluorescence in situ hybridization analysis revealed no MDM2 gene amplification. The present case indicates that duplication of 12q may be associated with minimal nuclear atypia in a subset of lipomatous tumors.

10.
JBJS Case Connect ; 6(1): e9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-29252715

RESUMO

CASE: We describe a middle-aged woman who had undergone periacetabular osteotomy (PAO) on both hips successively within a two-year period. Although the first PAO was successfully performed on the right hip without any complications, injury to the obturator artery occurred during the subsequent PAO on the left hip. In this case, the obturator artery seemed to be injured at the medial base of the iliopectineal eminence during osteotomy. CONCLUSION: PAO has been employed as a reconstructive surgery for acetabular dysplasia. However, given the proximity of intrapelvic vascular structures, there is a risk of iatrogenic vascular injury.

11.
Anticancer Res ; 35(11): 6167-70, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26504045

RESUMO

Glomus tumor is a rare perivascular neoplasm that usually occurs in the distal extremities of young adults. Recent molecular studies have identified microRNA 143-NOTCH fusions or NOTCH1-3 rearrangements in benign and malignant glomus tumors. Herein, we describe the cytogenetic and molecular cytogenetic findings of a glomus tumor arising in the left wrist of a 45-year-old man. Physical examination showed a 1.3-cm, blue-red, tender nodule. Magnetic resonance imaging demonstrated a subcutaneous, well-circumscribed mass with low signal intensity on T1-weighted sequences and high signal intensity on T2-weighted sequences. Contrast-enhanced fat-suppressed T1-weighted sequences showed a homogeneous, strong enhancement. A marginal excision was performed and histopathological examination confirmed the diagnosis of a glomus tumor. Cytogenetic and spectral karyotypic analyses showed a novel rearrangement involving chromosome bands 1p13 and 5q32. There has been no evidence of local recurrence four months after surgery. To the best of our knowledge, this is the first case of sporadic glomus tumor with t(1;5).


Assuntos
Cromossomos Humanos Par 1/genética , Cromossomos Humanos Par 5/genética , Tumor Glômico/genética , Tumor Glômico/patologia , Translocação Genética/genética , Adulto , Análise Citogenética , Tumor Glômico/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Prognóstico
12.
Int Orthop ; 39(11): 2281-6, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26318882

RESUMO

PURPOSE: Peri-acetabular osteotomy, especially curved peri-acetabular osteotomy, is an effective surgical procedure for re-orientating the acetabulum. However, there have been few reports on this procedure in teenagers. The purpose of this study was to investigate the treatment outcomes of curved peri-acetabular osteotomy in teenagers. METHODS: We retrospectively reviewed 33 hips in 27 teenage patients with acetabular dysplasia who underwent curved peri-acetabular osteotomy between 1995 and 2012. The mean age was 17.0 years (range, 14-19 years). The mean follow-up duration at the most recent physical examination was 33.3 months (range, 24-96 months). All hips were evaluated in terms of the Harris hip score, radiographic measurements, and complications. RESULTS: The mean Harris hip score improved from 80.1 points pre-operatively to 95.4 points post-operatively (p < 0.001). There were significant differences in all of the radiographic measurements between the pre-operative and post-operative values (p < 0.001). One major complication occurred (symptomatic ischial nonunion) and required subsequent surgery. Nine hips had minor complications, including nonunion of the superior ramus osteotomy (four hips), superficial stitch abscess (two hips), and transient lateral femoral cutaneous nerve palsy (three hips). CONCLUSIONS: Satisfactory results can be obtained clinically and radiographically after curved peri-acetabular osteotomy in adolescents. Osteotomy for acetabular dysplasia is effective in teenagers.


Assuntos
Acetábulo/cirurgia , Luxação Congênita de Quadril/cirurgia , Osteotomia/métodos , Adolescente , Feminino , Humanos , Masculino , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
13.
Mol Clin Oncol ; 3(3): 677-681, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-26137286

RESUMO

Periosteal chondroma is a rare benign hyaline cartilage neoplasm situated on the bone surface. This is the presentation of a unique case of periosteal chondroma arising in the left distal tibial metaphysis of a 25-year-old female patient with a history of antecedent trauma. The physical examination revealed swelling and tenderness in the anterolateral aspect of the left distal lower limb. Plain radiographs revealed a discernible soft tissue lesion with peripheral foci of mineralization. Computed tomography scans confirmed the presence of a surface-based mass with peripheral ossification and a thin rim of calcification. On magnetic resonance imaging, the well-circumscribed mass exhibited intermediate signal intensity on T1-weighted sequences and high signal intensity with foci of decreased signal intensity on T2-weighted sequences. Contrast-enhanced T1-weighted sequences revealed predominantly peripheral enhancement without intramedullary involvement. Following an open biopsy, marginal excision with curettage of the underlying bone cortex was performed. Histologically, the tumor consisted of mature hyaline cartilage arranged in distinct lobules. Foci of ossification with mature bone trabeculae forming a thin shell-like structure were identified in the periphery of the tumor. The mindbomb E3 ubiquitin protein ligase 1 labeling index was <1%. Based on these findings, the tumor was diagnosed as periosteal chondroma. There has been no evidence of local recurrence at 4 months following surgery. Despite its rarity, periosteal chondroma must be considered as a possible diagnosis when confronted with a surface-based, mineralized lesion in the metaphysis of long bones.

14.
Springerplus ; 4: 260, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26090307

RESUMO

BACKGROUND: It is often challenging to completely resect multinodular/plexiform schwannomas involving important deep nerves using minimally invasive surgically techniques. CASE DESCRIPTION: A 32-year-old woman presented with a 5-year history of a slowly growing, painful mass in the medial aspect of the right ankle. Magnetic resonance imaging (MRI) demonstrated multiple nodular lesions with iso-signal intensity relative to skeletal muscle on T1-weighted sequences and heterogeneous high signal intensity on T2-weighted sequences. Mild to moderate enhancement was identified after gadolinium administration. All 58 tumors were completely enucleated using an intracapsular technique. Histological examination confirmed the diagnosis of schwannoma consisting mainly of Antoni A areas. The burning sensation was relieved immediately after surgery. The patient had no aggravated neurological deficit and was very satisfied with the outcome of the treatment at final follow-up. DISCUSSION AND EVALUATION: We experienced a very rare case of a large multinodular/plexiform schwannoma arising from the posterior tibial nerve and its larger terminal branch. Our case had the characteristic MRI features of this condition. It is extremely important to differentiate multinodular/plexiform schwannoma from plexiform neurofibroma and malignant peripheral nerve sheath tumor, with complete surgical enucleation being curative. CONCLUSIONS: MRI is a clinically useful modality in the evaluation and detection of deep-seated multinodular/plexiform schwannoma. Intracapsular enucleation seems to be an acceptable treatment for this peculiar tumor located in the foot and ankle.

15.
Anticancer Res ; 35(2): 967-71, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25667482

RESUMO

Extrapleural solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm of intermediate biological potential. Herein, we describe the radiological, histological, immunohistochemical and molecular genetic features of an SFT arising in the left thigh of a 55-year-old woman. Magnetic resonance imaging exhibited a well-defined mass with intermediate signal intensity on T1-weighted sequences and heterogeneous high signal intensity on T2-weighted sequences. Contrast-enhanced T1-weighted sequences showed strong homogeneous enhancement of the mass. A prominent vascular pedicle was visible. Integrated positron-emission tomography (PET)/computed tomographic (CT) scan demonstrated a moderate 18F-fluorodeoxyglucose (FDG) uptake (maximum standardized uptake value, 4.45) in the mass. Following an open biopsy, wide excision of the tumor was performed. Histologically, the tumor was composed of a proliferation of spindle cells in a fibrous stroma with focal hyalinization. Thin-walled branching hemangiopericytoma-like vessels were observed. Immunohistochemically, the tumor cells were diffusely positive for signal transducer and activator of transcription 6 (STAT6) but negative for CD34. The MIB-1 labeling index was less than 5%. Subsequent reverse transcriptase-polymerase chain reaction analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity. To the best of our knowledge, this is the first report showing the FDG PET/CT findings of soft-tissue SFT.


Assuntos
Antígenos CD34/metabolismo , Fluordesoxiglucose F18 , Imagem Multimodal , Proteínas Repressoras/genética , Fator de Transcrição STAT6/genética , Tumores Fibrosos Solitários/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons , Proteínas Recombinantes de Fusão/genética , Tumores Fibrosos Solitários/genética , Tumores Fibrosos Solitários/imunologia , Tomografia Computadorizada por Raios X
16.
J Orthop Sci ; 20(3): 507-12, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25687655

RESUMO

PURPOSE: The purpose of this study was to determine the relationship between the defect-to-ankle articular length ratio and clinical outcomes after arthroscopic bone marrow stimulation. METHODS: Seventeen male and 24 female patients (mean age 36.0 years, height 160.7 cm, weight 62.5 kg, body mass index 24.0) with an osteochondral lesion of the talus were treated with arthroscopic bone marrow stimulation and assessed using the Japanese Society for Surgery of the Foot (JSSF) ankle-hindfoot scale, Berndt and Harty scales and clinical outcome criteria. The lengths of the tibial and talar articular surfaces were defined from the anterior tip to posterior tip of the articular cartilage on sagittal magnetic resonance imaging scans. The size of the defect area was defined and determined for each patient on magnetic resonance images using coronal length, sagittal length, and area. The relationship between clinical outcome and sagittal tibia ratio (sagittal length of defect/length of tibia articular cartilage) and sagittal talus ratio (sagittal length of defect/length of talus articular cartilage) were assessed. RESULTS: The mean lesion length was 11 mm (range 6-14 mm), lesion size was 67 mm(2) (range 19-134 mm(2)), sagittal tibia ratio was 0.42 (range 0.21-0.75), and sagittal talus ratio was 0.32 (range 0.16-0.58). The mean JSSF scale improved from 74 (range 18-90) to 89 (range 67-100) postoperatively. Lesion area was not associated with the JSSF scale (r = -0.10, P = 0.52). Talus articular length (r = 0.64, P < 0.0001) and tibia articular length (r = 0.64, P < 0.0001) were correlated with patient height. The sagittal talus ratio and sagittal tibia ratio were not associated with the JSSF scale (r = -0.10, P = 0.55; r = -0.02, P = 0.90). CONCLUSION: Arthroscopic bone marrow stimulation provides good clinical outcomes in small osteochondral lesions of the talus (<15 mm). For small lesions, the lesion size is not a prognostic factor. LEVEL OF EVIDENCE: IV: Retrospective Case Series.


Assuntos
Artroplastia Subcondral , Artroscopia , Medula Óssea/cirurgia , Cartilagem Articular/cirurgia , Osteocondrite/cirurgia , Tálus/cirurgia , Adulto , Cartilagem Articular/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Osteocondrite/patologia , Tálus/patologia , Resultado do Tratamento
17.
Anticancer Res ; 35(1): 345-50, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25550570

RESUMO

Dedifferentiated liposarcoma (DDLS) is a malignant adipocytic tumor showing transition from an atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLS) to a non-lipogenic sarcoma of variable histological grades. We present the immunohistochemical, cytogenetic, and molecular cytogenetic findings of DDLS arising in the right chest wall of a 76-year-old man. Magnetic resonance imaging exhibited a large mass composed of two components with heterogeneous signal intensities, suggesting the coexistence of a fatty area and another soft tissue component. The grossly heterogeneous mass was histologically composed of an ALT/WDLS component transitioning abruptly into a dedifferentiated component. Immunohistochemistry was positive for murine double-minute 2 (MDM2), cyclin-dependent kinase 4 (CDK4), and p16 in both components, although a more strong and diffuse staining was found in the dedifferentiated area. The MIB-1 labeling index was extremely higher in the dedifferentiated area compared to the ALT/WDLS area. Cytogenetic analysis of the ALT/WDLS component revealed the following karyotype: 46,X,-Y,+r. Notably, cytogenetic analysis of the dedifferentiated component revealed a similar but more complex karyotype. Spectral karyotyping demonstrated that the ring chromosome was entirely composed of material from chromosome 12. Interphase fluorescence in situ hybridization analysis revealed amplification of MDM2 and CDK4 in both components. These findings suggest that multiple abnormal clones derived from a single precursor cell would be present in DDLS, with one or more containing supernumerary rings or giant marker chromosomes.


Assuntos
Lipossarcoma/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico , Cariótipo Anormal , Idoso , Carcinogênese/genética , Humanos , Imuno-Histoquímica , Cariotipagem , Lipossarcoma/genética , Lipossarcoma/cirurgia , Masculino , Cromossomos em Anel , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/cirurgia
18.
Hip Int ; 25(2): 164-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25633759

RESUMO

PURPOSE: We performed curved periacetabular osteotomy, a modification of the Bernese periacetabular osteotomy, to treat hip dysplasia. The purpose of our study was to compare the biomechanical stability of acetabular fragments fixed in place with 3 titanium screws, or with 2 or 3 bioabsorbable screws composed of particulate resorbable uncalcined hydroxyapatite (HA) and poly-L-lactic acid (PLLA) termed HA/PLLA screws. METHODS: Curved periacetabular osteotomy was performed on 24 composite model hemipelves. Three groups of 8 specimens were affixed with 1) 3 titanium screws, 2) 2 HA/PLLA screws, or 3) 3 HA/PLLA screws. After fixation, the hemipelves were biomechanically attested with simulated push-off phase of the gait cycle using a servohydraulic material testing system. RESULTS: The average failure loads were not significantly different among the3 groups tested. However, the group repaired with 3 HA/PLLA screws showed significantly greater stiffness than the other groups. CONCLUSIONS: All 3 fixation methods provided sufficient stability to allow for early partial weight-bearing after surgery. The use of 3 HA/PLLA screws provided significantly greater stiffness for acetabular fragment fixation.


Assuntos
Implantes Absorvíveis , Acetábulo/cirurgia , Osteotomia/instrumentação , Estresse Mecânico , Titânio , Fenômenos Biomecânicos , Parafusos Ósseos , Durapatita , Humanos , Teste de Materiais , Modelos Anatômicos , Osteotomia/métodos
19.
Mol Clin Oncol ; 3(1): 207-211, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25469296

RESUMO

The patella is a rare site for the development of primary tumors. This is the case report of a giant cell tumor (GCT) occurring in the patella in a 25-year-old woman. The patient presented with a 1-year history of occasional right anterior knee pain. The radiological characteristics suggested a benign condition. The intraoperative pathological diagnosis was GCT of the bone. The lesion was treated by radical curettage with adjuvant therapy comprising phenol and ethanol and injection of calcium phosphate cement. Histologically, the tumor consisted of round or spindle-shaped mononuclear cells admixed with numerous osteoclastic giant cells. The patient was asymptomatic and there was no evidence of local recurrence or distant metastasis 16 months after surgery. Although rare, patellar GCT may be included in the differential diagnosis of anterior knee pain and/or swelling, particularly in young adults.

20.
J Foot Ankle Surg ; 54(1): 37-40, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25459094

RESUMO

Inadequate primary treatment of calcaneal fractures frequently results in persistent, residual pain. This can be caused by subtalar arthritis, an increased calcaneal width, and/or calcaneal fibular impingement of the peroneal tendons. Many patients experience multiple disorders simultaneously, requiring a combination of procedures to treat the injury. The purpose of the present study was to evaluate the clinical outcomes of arthroscopic debridement with lateral calcaneal ostectomy for residual pain after a calcaneal fracture. Four feet (4 patients) were treated with arthroscopic debridement and lateral calcaneal ostectomy. The patients were 3 males and 1 female, with a mean age of 55.3 ± 14.1 years. The mean follow-up duration was 33.5 ± 10.5 months postoperatively. Three patients received worker's compensation as a result of their condition. The patients were examined for improvement in pain levels using the numeric pain intensity scale and healing was assessed using the Japanese Society of Surgery of the Foot score. The mean Japanese Society of Surgery of the Foot score improved from 64.5 ± 13.8 preoperatively to 82.5 ± 7.1 postoperatively. The mean postoperative numeric pain intensity scale score was 2.3 ± 1.9. No complications, such as deep infection or problems with wound healing, were observed in any of the patients. The simultaneous use of arthroscopic subtalar debridement and lateral calcaneal ostectomy is a valuable intervention for the treatment of residual pain after a calcaneal fracture in patients who present with increased calcaneal width and mild or no degenerative changes in the subtalar joint.


Assuntos
Calcâneo/cirurgia , Fraturas Ósseas/cirurgia , Adulto , Idoso , Artroscopia , Calcâneo/lesões , Desbridamento , Feminino , Fraturas Ósseas/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Osteotomia , Dor/etiologia , Dor/cirurgia , Tálus/cirurgia
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