RESUMO
Mammary analog secretory carcinoma (MASC) of the parotid gland is a rare and recently described lesion. We report the case of a 46-year-old man with a tumor of the parotid gland which was carried to the diagnosis of MASC. Diagnostic was confirmed by highlighting the ETV6-NTRK3 gene translocation. However, some morphologic and immunohistochemical features are suggestive of this entity. This carcinoma should be distinguished from its main differential diagnoses: acinic cell carcinoma and low grade cribriform cystadenocarcinoma.
Assuntos
Carcinoma/patologia , Neoplasias Parotídeas/patologia , Biomarcadores Tumorais/análise , Carcinoma/química , Carcinoma/genética , Carcinoma de Células Acinares , Cistadenocarcinoma , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/genética , Neoplasias Parotídeas/química , Neoplasias Parotídeas/genética , Translocação GenéticaAssuntos
Antineoplásicos/efeitos adversos , Indóis/efeitos adversos , Neoplasias Renais/patologia , Pirróis/efeitos adversos , Glândula Tireoide/diagnóstico por imagem , Tireotoxicose/induzido quimicamente , Tireotoxicose/patologia , Adulto , Antineoplásicos/uso terapêutico , Feminino , Bócio/etiologia , Bócio/patologia , Humanos , Indóis/uso terapêutico , Neoplasias Renais/tratamento farmacológico , Pirróis/uso terapêutico , Sunitinibe , Testes de Função Tireóidea , Tomografia Computadorizada por Raios XRESUMO
OBJECTIVES/HYPOTHESIS: Advanced carcinoma of the tongue can require total glossectomy. Although radiation therapy is of limited efficacy in T3 and T4 tumors involving the base of the tongue, many surgeons are reluctant to suggest highly mutilating surgery. STUDY DESIGN: Retrospective cohort study. METHODS: We compared early postoperative complications, hospital stay duration, function, and oncological outcomes in patients who underwent total glossectomy without laryngectomy as first-line or salvage therapy. RESULTS: Postoperative course and functional outcomes were similar in the two groups. Overall survival was 32% at 3 years and 21% at 5 years. The risk factors for shorter survival were positive margins of resection (P =.002) and tumor spread into the mandible (P =.04). Salvage surgery was not associated with significantly lower survival (P =.09 [NS]). CONCLUSIONS: Postoperative morbidity and functional outcomes are similar after first-line and salvage total glossectomy without laryngectomy. Local tumor control is the main factor influencing survival.