Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 32
Filtrar
1.
Br J Neurosurg ; : 1-4, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34620013

RESUMO

OBJECTIVE: The infrafloccular approach in microvascular decompression (MVD) surgery for hemifacial spasm (HFS) was investigated for the prevention of hearing complications. METHODS: Retrospective analysis of 136 patients who underwent MVD for HFS in 2019. The infrafloccular approach for MVD was adopted to resolve the symptom and protect hearing function. Postoperative hearing function was evaluated subjectively and objectively within 30 postoperative days, and later mainly subjectively. Postoperative condition of mastoid air cells based on the CT scan of the following day was also recorded. RESULTS: No final postoperative subjective hearing impairment was found in all patients. Mastoid air cells were opened in 105 patients, and subjective hearing impairment was recorded in 57 patients within 30 postoperative days, but all improved later. Increases in thresholds of greater than 10 dB in air conduction were observed in 28 patients, including 26 of transient conductive hearing loss (increases in the threshold of less than or equal to 10 dB). The other 2 patients with increases in the threshold of greater than 10 dB in both air and bone conduction had improvement confirmed by later audiometry. CONCLUSIONS: Infrafloccular approach in MVD for HFS provides a good hearing outcome. Inclusion of postoperative hearing conditions in the later period is ideal for a precise hearing evaluation.

2.
Curr Med Res Opin ; 37(7): 1121-1134, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33989102

RESUMO

OBJECTIVE: To examine treatment patterns of real-world antifungal management of patients at high risk of invasive fungal infections (IFI) and evaluate healthcare resource utilization and costs associated with antifungal management of IFIs in Japan. METHODS: This retrospective, observational study extracted data from a hospital-based claims database for patients in Japan who either (a) underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), or (b) were hospitalized with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) and received chemotherapy during the study period of January 2010 to January 2019. RESULTS: 863 patients were included in the allo-HSCT cohort and 4498 patients were included in the AML/MDS cohort. In the allo-HSCT cohort, 91% received more than one antifungal drug during the index hospitalization. In the AML/MDS cohort, approximately 50% received more than one antifungal drug during the index hospitalization. For both the allo-HSCT and AML/MDS cohorts, about 90% of the total cost was attributed to inpatient costs. Of note, both the total cost (the total inpatient and outpatient cost) and the index hospitalization costs were higher in patients treated with multiple antifungal drugs than in those treated with a single antifungal drug during the index hospitalization. Despite being at high IFI risk, 12% of the patients in the AML/MDS cohort did not receive antifungal drugs during the index hospitalization. CONCLUSIONS: Most patients with hematologic malignancy and high IFI risk underwent complicated antifungal management requiring use of multiple drugs, and accounted for high healthcare resource utilization and costs.


Assuntos
Neoplasias Hematológicas , Leucemia Mieloide Aguda , Antifúngicos/uso terapêutico , Efeitos Psicossociais da Doença , Neoplasias Hematológicas/complicações , Neoplasias Hematológicas/tratamento farmacológico , Humanos , Japão , Leucemia Mieloide Aguda/tratamento farmacológico , Aceitação pelo Paciente de Cuidados de Saúde , Estudos Retrospectivos
3.
Curr Med Res Opin ; 37(2): 253-260, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33143482

RESUMO

OBJECTIVE: To evaluate outcomes, healthcare resource utilization, and costs associated with mucormycosis in inpatient settings in Japan. METHODS: We performed a systematic literature review, followed by a retrospective database study using hospital health claims for patients in Japan hospitalized with a diagnosis of mucormycosis between January 2010 and January 2019. Outcomes assessed included duration of index hospitalization; index stay mortality; hospital readmission within 30, 60, and 90 days after index hospitalization discharge; drug/treatment utilization and patterns; number of patients examined for mucormycosis during the index hospitalization; and index stay inpatient costs. RESULTS: From our systematic literature review of articles describing 133 patients with mucormycosis, mortality in the index hospitalization was 55.6%. From our database study of 126 patients hospitalized for mucormycosis, mortality during the index hospitalization was 35.7% and mean index stay duration was 94 days. Hematologic malignancies were the most common risk factor in the literature review and the most common comorbidity in the database study. During the index stay, 39 patients (31.0%) received liposomal amphotericin B (L-AMB) treatment and 74 patients (58.7%) received other antifungal treatments. Median total inpatient costs for the index hospitalization were equivalent to approximately US$60,945, including US$29,283 in drug costs. CONCLUSIONS: This study investigated the healthcare resource utilization and cost of medical resources caused by mucormycosis in Japan. The drug costs for antifungal treatments comprised about half of total inpatient costs. Mucormycosis leads to high mortality, high healthcare resource utilization, and high costs.


Assuntos
Efeitos Psicossociais da Doença , Mucormicose/economia , Humanos , Japão/epidemiologia , Mucormicose/tratamento farmacológico , Mucormicose/epidemiologia , Estudos Retrospectivos
4.
J Antibiot (Tokyo) ; 73(8): 574-580, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32313168

RESUMO

Serine is an essential component in organisms as a building block of biomolecules, a precursor of metabolites, an allosteric regulator of an enzyme, etc. This amino acid is thought to be a key metabolite in human diseases including cancers and infectious diseases. To understand the consequence of serine catabolism, we screened natural products to identify a fungal metabolite chaetoglobosin D (ChD) as a specific inhibitor of fission yeast cell growth when cultivated with serine as a sole nitrogen source. ChD targets actin, and actin mutant cells showed severe growth defect on serine medium. ROS accumulated in cells when cultivated in serine medium, while actin mutant cells showed increased sensitivity to oxidative stress. ROS production is a new aspect of serine metabolism, which might be involved in disease progression, and actin could be the drug target for curing serine-dependent symptoms.


Assuntos
Actinas/metabolismo , Proliferação de Células/fisiologia , Espécies Reativas de Oxigênio/metabolismo , Schizosaccharomyces/metabolismo , Aminoácidos/metabolismo , Humanos , Alcaloides Indólicos/metabolismo , Estresse Oxidativo/fisiologia , Serina/metabolismo
5.
Curr Med Res Opin ; 35(12): 2089-2096, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31353971

RESUMO

Introduction: Reactivation of cytomegalovirus (CMV) infection is a major threat and it causes significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). There remains, however, a paucity of evidence regarding the economic burden of current CMV management in Japan. The aim of this study is to characterize the healthcare resource utilization (HCRU) and cost incurred for CMV management post allo-HSCT, using a Japanese hospital claims database.Methods: Patients who underwent allo-HSCT between April 2010 and March 2018 were identified and followed up for 180 days.Results: In total, 916 patients were included for analysis and categorized into CMV (-) group and CMV (+) group based on the presence of a CMV episode within 100 days post allo-HSCT. A CMV episode was defined as evidence of receiving at least one dose of the following anti-CMV drugs, ganciclovir, foscarnet, or valganciclovir. The mean (± standard deviation [SD]) total length of stay was 93.6 (± 43.7) days in the CMV (+) group, which was significantly longer than 55.9 (±40.6) days in the CMV (-) group, and this trend was more pronounced in patients with multiple CMV episodes. The mean (±SD) total medical cost within 180 days post allo-HSCT was US$122,328 (±56,977) in the CMV (+) group, while the mean total medical cost was US$75,344 (±43,821) in the CMV (-) group. Moreover, transfusion and antimicrobial use was observed as the major medication cost component, which is suggestive of the indirect effect of CMV episodes.Conclusion: This study demonstrated that CMV episodes post allo-HSCT were associated with increased HCRU and cost.


Assuntos
Antivirais , Efeitos Psicossociais da Doença , Infecções por Citomegalovirus , Transplante de Células-Tronco Hematopoéticas , Hospitalização , Complicações Pós-Operatórias , Antivirais/classificação , Antivirais/economia , Antivirais/uso terapêutico , Infecções por Citomegalovirus/economia , Infecções por Citomegalovirus/etiologia , Infecções por Citomegalovirus/terapia , Feminino , Alocação de Recursos para a Atenção à Saúde/estatística & dados numéricos , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Transplante de Células-Tronco Hematopoéticas/métodos , Hospitalização/economia , Hospitalização/estatística & dados numéricos , Humanos , Revisão da Utilização de Seguros , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/economia , Complicações Pós-Operatórias/terapia , Estudos Retrospectivos , Transplante Homólogo/efeitos adversos , Transplante Homólogo/métodos
6.
Org Lett ; 20(15): 4406-4410, 2018 08 03.
Artigo em Inglês | MEDLINE | ID: mdl-30024763

RESUMO

The highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property of 2-aminophenol. Unexpectedly, 2-aminophenol in saccharothriolide B was eliminated through a retro-Michael reaction, to yield presaccharothriolide X under physiological conditions. 2-Aminophenol might be developed into a useful protecting group for bioactive small molecules with an α,ß-unsaturated ketone.


Assuntos
Actinobacteria/química , Macrolídeos/química , Aminofenóis/química , Anti-Infecciosos/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Citotoxinas/química , Citotoxinas/farmacologia , Humanos , Macrolídeos/farmacologia , Estrutura Molecular , Oxirredução , Schizosaccharomyces/citologia , Schizosaccharomyces/efeitos dos fármacos
8.
Elife ; 52016 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-27657169

RESUMO

Exosomes are extracellular vesicles that are released when endosomes fuse with the plasma membrane. They have been implicated in various functions in both health and disease, including intercellular communication, antigen presentation, prion transmission, and tumour cell metastasis. Here we show that inactivating the vacuolar ATPase in HeLa cells causes a dramatic increase in the production of exosomes, which display endocytosed tracers, cholesterol, and CD63. The exosomes remain clustered on the cell surface, similar to retroviruses, which are attached to the plasma membrane by tetherin. To determine whether tetherin also attaches exosomes, we knocked it out and found a 4-fold reduction in plasma membrane-associated exosomes, with a concomitant increase in exosomes discharged into the medium. This phenotype could be rescued by wild-type tetherin but not tetherin lacking its GPI anchor. We propose that tetherin may play a key role in exosome fate, determining whether they participate in long-range or short-range interactions.

9.
J Nat Prod ; 79(7): 1891-5, 2016 07 22.
Artigo em Inglês | MEDLINE | ID: mdl-27332142

RESUMO

Three new 10-membered macrolides, saccharothriolides D-F (1-3), were isolated from a rare actinomycete, Saccharothrix sp. A1506. The planar structures were determined from analysis of extensive NMR and HR-ESI-MS data, and the absolute configurations were established by ECD spectroscopy analysis. Saccharothriolides D (1) and E (2) were determined to be C-2 epimers of saccharothriolides A (4) and B (5), respectively. Saccharothriolide F (3) was identified to be a demethylated congener of saccharothriolides D (1) and A (4) at the C-2 position. The availability of compounds 1-6 enabled a structure-activity relationship study that revealed the importance of the phenolic hydroxy group at C-2″ and the stereochemistry of C-2 for the inhibition of human fibrosarcoma HT1080 cell growth.


Assuntos
Actinomycetales/química , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Macrolídeos/isolamento & purificação , Macrolídeos/farmacologia , Antineoplásicos/química , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Macrolídeos/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Relação Estrutura-Atividade
10.
Org Lett ; 17(21): 5364-7, 2015 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-26484856

RESUMO

The transcriptional factor, hypoxia inducible factor-1 (HIF-1), is a promising target for cancer chemotherapy. From an actinomycete, verucopeptin (1) was identified as a HIF-1 signaling inhibitor. By a combination of chemical degradation and spectroscopic analyses, the absolute stereochemistry of metabolite 1 was determined to be 10R, 15S, 16S, 23S, 27S, 28R, 31S, 33S, 35R. Moreover, metabolite 1 was revealed to attenuate the HIF-1α and mTORC1 pathway, indicating that verucopeptin (1) would be a potent lead compound for anticancer chemotherapy.


Assuntos
Actinobacteria/química , Depsipeptídeos/química , Depsipeptídeos/farmacologia , Antineoplásicos/química , Antineoplásicos/farmacologia , Humanos , Subunidade alfa do Fator 1 Induzível por Hipóxia/antagonistas & inibidores , Alvo Mecanístico do Complexo 1 de Rapamicina , Estrutura Molecular , Complexos Multiproteicos/efeitos dos fármacos , Policetídeos/farmacologia , Estereoisomerismo , Serina-Treonina Quinases TOR/efeitos dos fármacos
11.
Chem Biol ; 22(5): 604-10, 2015 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-25960262

RESUMO

Roles of lipids in the cell membrane are poorly understood. This is partially due to the lack of methodologies, for example, tool chemicals that bind to specific membrane lipids and modulate membrane function. Theonellamides (TNMs), marine sponge-derived peptides, recognize 3ß-hydroxysterols in lipid membranes and induce major morphological changes in cultured mammalian cells through as yet unknown mechanisms. Here, we show that TNMs recognize cholesterol-containing liquid-disordered domains and induce phase separation in model lipid membranes. Modulation of membrane order was also observed in living cells following treatment with TNM-A, in which cells shrank considerably in a cholesterol-, cytoskeleton-, and energy-dependent manner. These findings present a previously unrecognized mode of action of membrane-targeting natural products. Meanwhile, we demonstrated the importance of membrane order, which is maintained by cholesterol, for proper cell morphogenesis.


Assuntos
Membrana Celular/metabolismo , Colesterol/química , Peptídeos Cíclicos/química , Animais , Linhagem Celular Tumoral , Membrana Celular/efeitos dos fármacos , Forma Celular/efeitos dos fármacos , Colesterol/metabolismo , Citoesqueleto/química , Citoesqueleto/efeitos dos fármacos , Citoesqueleto/metabolismo , Humanos , Bicamadas Lipídicas/química , Bicamadas Lipídicas/metabolismo , Lipossomos/química , Lipossomos/metabolismo , Microscopia de Fluorescência , Peptídeos Cíclicos/isolamento & purificação , Peptídeos Cíclicos/farmacologia , Ligação Proteica , Theonella/metabolismo , Tubulina (Proteína)/metabolismo
12.
Chem Commun (Camb) ; 51(38): 8074-7, 2015 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-25869768

RESUMO

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.


Assuntos
Actinomycetales/química , Macrolídeos/isolamento & purificação , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Células HeLa , Humanos , Macrolídeos/química , Macrolídeos/farmacologia , Conformação Molecular , Teoria Quântica , Relação Estrutura-Atividade
13.
Bioorg Med Chem ; 23(8): 1776-87, 2015 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-25773014

RESUMO

Hypoxia-inducible factor (HIF)-1 is well known as a promising target for cancer chemotherapy. By screening an in-house chemical library using a hypoxia-responsive luciferase reporter gene assay, we identified CLB-016 (1) containing 1-ethylpyrazole-3-carboxamide as a HIF-1 inhibitor (IC50=19.1µM). In a subsequent extensive structure-activity relationship (SAR) study, we developed compound 11Ae with an IC50 value of 8.1µM against HIF-1-driven luciferase activity. Compounds 1 and 11Ae were shown to significantly suppress the HIF-1-mediated hypoxia response, including carbonic anhydrase IX (CAIX) gene expression and migration of human sarcoma HT1080 cells. These results revealed 1-ethylpyrazole-3-carboxamide as a novel scaffold to develop promising anti-cancer drugs targeting the HIF-1 signaling pathway.


Assuntos
Antineoplásicos/química , Antineoplásicos/farmacologia , Desenho de Fármacos , Fator 1 Induzível por Hipóxia/antagonistas & inibidores , Pirazóis/química , Pirazóis/farmacologia , Antineoplásicos/síntese química , Hipóxia Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Humanos , Fator 1 Induzível por Hipóxia/metabolismo , Neoplasias/tratamento farmacológico , Neoplasias/metabolismo , Pirazóis/síntese química , Bibliotecas de Moléculas Pequenas/síntese química , Bibliotecas de Moléculas Pequenas/química , Bibliotecas de Moléculas Pequenas/farmacologia , Relação Estrutura-Atividade
14.
Org Lett ; 17(2): 258-61, 2015 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-25560738

RESUMO

Two new microbial metabolites, tryptopeptins A (1) and B (2), were isolated from the cultured broth of Streptomyces sp. KUSC-G11, as modulators of the transforming growth factor-ß (TGF-ß) signaling pathway. Their chemical structures consisting of isovalerate, N-Me-L-Val, L-allo-Thr, and a tryptophan-related residue were elucidated on the basis of spectroscopic analyses, while they were unambiguously determined by total syntheses. A structure-activity relationship (SAR) study using natural and synthesized tryptopeptins revealed the importance of the α,ß-epoxyketone function located at the C terminus. These new TGF-ß signaling modulators would be highly useful for development of new drug leads targeting TGF-ß-related diseases such as fibrosis and cancer.


Assuntos
Oligopeptídeos/síntese química , Streptomyces/química , Fator de Crescimento Transformador beta/química , Bioensaio/métodos , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Oligopeptídeos/química , Oligopeptídeos/farmacologia , Transdução de Sinais , Estereoisomerismo , Relação Estrutura-Atividade
15.
Chemistry ; 21(3): 1096-101, 2015 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-25404228

RESUMO

Discovery of a new class of ion intercalation compounds is highly desirable due to its relevance to various electrochemical devices, such as batteries. Herein, we present a new iron-oxalato open framework, which showed reversible Na(+) intercalation/extraction. The hydrothermally synthesized K4Na2[Fe(C2O4)2]3⋅2 H2O possesses one-dimensional open channels in the oxalato-bridged network, providing ion accessibility up to two Na(+) per the formula unit. The detailed studies on the structural and electronic states revealed that the framework exhibited a solid solution state almost entirely during Na(+) intercalation/extraction associated with the reversible redox of Fe. The present work demonstrates possibilities of the oxalato frameworks as tunable and robust ion intercalation electrode materials for various device applications.

16.
Cell ; 155(4): 793-806, 2013 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-24209618

RESUMO

The eukaryotic biological clock involves a negative transcription-translation feedback loop in which clock genes regulate their own transcription and that of output genes of metabolic significance. While around 10% of the liver transcriptome is rhythmic, only about a fifth is driven by de novo transcription, indicating mRNA processing is a major circadian component. Here, we report that inhibition of transmethylation reactions elongates the circadian period. RNA sequencing then reveals methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation. We identify m(6)A sites on many clock gene transcripts and show that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 is sufficient to elicit circadian period elongation and RNA processing delay. Analysis of the circadian nucleocytoplasmic distribution of clock genes Per2 and Arntl then revealed an uncoupling between steady-state pre-mRNA and cytoplasmic mRNA rhythms when m(6)A methylation is inhibited.


Assuntos
Relógios Circadianos , Metiltransferases/metabolismo , Processamento Pós-Transcricional do RNA , RNA/metabolismo , Translocador Nuclear Receptor Aril Hidrocarboneto/metabolismo , Linhagem Celular , Linhagem Celular Tumoral , Técnicas de Silenciamento de Genes , Humanos , Metilação/efeitos dos fármacos , Metiltransferases/genética , Proteínas Circadianas Period/metabolismo , Tubercidina/farmacologia
17.
Open Ophthalmol J ; 7: 85-6, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24511333

RESUMO

We report the incidence of lacrimal passage impairment and specific features of corneal epitheliopathy as adverse effects of the oral anticancer drug S-1, and examine the relationship between the two pathologies. We conducted a retrospective chart review of 84 patients prescribed the anticancer drug S-1. The incidence of lacrimal passage impairment and corneal epitheliopathy was 8% and 6%, respectively. Three patients experienced both pathologies, demonstrating a moderate probability of both occurring in the same patient (kappa coefficient = 0.46). The findings show that lacrimal passage impairment and specific features of corneal epitheliopathy are likely to occur in the same individual as adverse effects of S-1.

18.
Auris Nasus Larynx ; 39(3): 317-20, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21862263

RESUMO

Schwannomas of the larynx are rare. Furthermore, a laryngeal schwannoma extending to the neck region is extremely rare. The present case report describes a 37-year-old male patient with a history of hoarseness and cervical swelling on the left side for over 10 years. He presented with dyspnea on exertion. Fiberoptic laryngoscopy revealed a large submucosal mass in the left false and true vocal folds, and the left vocal fold was immobile. Magnetic resonance imaging revealed the presence of multiple tumors throughout the body, in addition to extension of the laryngeal tumor to the left neck region in a dumbbell shape. After analysis of the results of examinations including imaging tests and pathological examinations, a diagnosis of schwannomatosis was made. A tracheostomy was performed, along with resection of the laryngeal tumor. Following disarticulation of the cricothyroid joint and rotate ion of the thyroid cartilage, the intralaryngeal part of the tumor was smoothly removed without median or lateral thyrotomy. At the 3-month follow-up, the patient's vocal fold mobility was found to have recovered. Although uncommon, our procedure was very effective for the treatment of laryngeal schwannomas. By this approach, safe removal of the tumor was possible, without any injury to the laryngeal mucosa.


Assuntos
Neoplasias de Cabeça e Pescoço/patologia , Neoplasias Laríngeas/patologia , Neurilemoma/patologia , Adulto , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Neoplasias Laríngeas/diagnóstico por imagem , Neoplasias Laríngeas/cirurgia , Masculino , Invasividade Neoplásica , Neurilemoma/diagnóstico por imagem , Neurilemoma/cirurgia , Tomografia Computadorizada por Raios X
19.
Mol Biosyst ; 7(5): 1463-72, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21340088

RESUMO

Identification of the cellular target of small molecules is a major challenge to developing biological tools and drug leads. Here we report a novel microarray-based system for identification of the target or the target pathway of small molecules using a set of drug-hypersensitive fission yeast strains that collectively overexpress each gene in the open reading frame-ome. The major advantage of this method is that it provides genome-wide interrogation but requires a relatively small amount of the test compound. Using this system, we identified 28 genes linked to etoposide sensitivity, which included genes for the drug target topoisomerase II and other plausible factors that regulate etoposide tolerance. Thus, our approach can accelerate the process of target identification of small molecules, which has the potential to reveal highly conserved genes of clinical relevance.


Assuntos
Análise de Sequência com Séries de Oligonucleotídeos/métodos , Fases de Leitura Aberta/genética , Schizosaccharomyces/efeitos dos fármacos , Schizosaccharomyces/genética , Xenobióticos/farmacologia , Antifúngicos/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Brefeldina A/farmacologia , Relação Dose-Resposta a Droga , Farmacorresistência Fúngica/genética , Etoposídeo/farmacologia , Fluconazol/farmacologia , Proteínas Fúngicas/genética , Regulação Fúngica da Expressão Gênica/efeitos dos fármacos , Genoma Fúngico/genética , Miconazol/farmacologia , Testes de Sensibilidade Microbiana , Schizosaccharomyces/crescimento & desenvolvimento
20.
J Am Chem Soc ; 132(39): 13596-7, 2010 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-20831186

RESUMO

A new pyrophosphate compound Li(2)FeP(2)O(7) was synthesized by a conventional solid-state reaction, and its crystal structure was determined. Its reversible electrode operation at ca. 3.5 V vs Li was identified with the capacity of a one-electron theoretical value of 110 mAh g(-1) even for ca. 1 µm particles without any special efforts such as nanosizing or carbon coating. Li(2)FeP(2)O(7) and its derivatives should provide a new platform for related lithium battery electrode research and could be potential competitors to commercial olivine LiFePO(4), which has been recognized as the most promising positive cathode for a lithium-ion battery system for large-scale applications, such as plug-in hybrid electric vehicles.


Assuntos
Difosfatos/química , Fontes de Energia Elétrica , Ferro/química , Lítio/química , Difosfatos/síntese química , Eletroquímica , Eletrodos , Modelos Moleculares
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA