Day-case laparoscopic ventral rectopexy: an achievable reality.

AIM: Laparoscopic ventral rectopexy (LVR) is a non-resectional technique for selected patients with full-thickness rectal prolapse and obstructed defaecation syndrome. Despite its challenges, LVR can be performed with relatively minimal patient trauma thus creating the potential for same-day discharge. Our aim was to assess the safety of day-case LVR and identify factors associated with same-day discharge. METHOD: Data were prospectively collected on all patients (n = 120) from June 2008 to October 2011. Variables included demographics, perioperative details and postoperative course. Primary outcome was length of stay and secondary outcome was symptom improvement at the latest outpatient follow-up. Patients discharged the same day after LVR were compared with those who stayed overnight or longer. RESULTS: Indications included rectocele and internal prolapse (47%), full-thickness rectal prolapse (44%) and other (9%). Mean operative time was 97 min, same-day discharge occurred with 23% (n = 27) and 67% (n = 80) were discharged on postoperative day 1. In terms of complications, 89% had none, 8% minor and 3% major, including one 24-h readmission for pain. Logistic regression identified younger age (P = 0.054) and private insurance status (P < 0.001) as being significantly associated with same-day discharge. Although surgical indication (P < 0.001), no prior hysterectomy (P = 0.012) and use of biological mesh (P = 0.012) had significant association they were probably confounded by age. CONCLUSION: In selected patients with rectal prolapse or obstructed defaecation, same-day discharge after LVR is feasible and safe. Our analysis identified quicker discharge in the private system with younger patients. Nevertheless, in unselected patients 90% were discharged by the first operative day.

Multidisciplinary management of Hunter syndrome.

Hunter syndrome is a rare, X-linked disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase. In the absence of sufficient enzyme activity, glycosaminoglycans accumulate in the lysosomes of many tissues and organs and contribute to the multisystem, progressive pathologies seen in Hunter syndrome. The nervous, cardiovascular, respiratory, and musculoskeletal systems can be involved in individuals with Hunter syndrome. Although the management of some clinical problems associated with the disease may seem routine, the management is typically complex and requires the physician to be aware of the special issues surrounding the patient with Hunter syndrome, and a multidisciplinary approach should be taken. Subspecialties such as otorhinolaryngology, neurosurgery, orthopedics, cardiology, anesthesiology, pulmonology, and neurodevelopment will all have a role in management, as will specialty areas such as physiotherapy, audiology, and others. The important management topics are discussed in this review, and the use of enzyme-replacement therapy with recombinant human iduronate-2-sulfatase as a specific treatment for Hunter syndrome is presented.

Female sexual dysfunction after ileal pouch-anal anastomosis.

BACKGROUND: The aim was to measure female sexual function after total proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis using a validated scoring system and to determine the impact of pouch function on sexual function. METHODS: A cross-sectional survey was performed using a modified version of the Female Sexual Function Index (FSFI-m). Measures of pouch function, including the Faecal Incontinence Severity Index, were also evaluated. RESULTS: Of 166 women eligible for inclusion, 90 responded to the questionnaires and 83 of these reported sexual activity. The mean age of the 83 women was 38.4 years and the mean time since pouch formation was 6.2 years. Thirty-nine women (47.0 per cent) had an FSFI-m score of 26 or less, indicating sexual dysfunction. The association between sexual dysfunction and stool leakage interfering with the ability to enjoy sexual activity tended toward significance (P = 0.071), but other measures of pouch function were not associated with sexual dysfunction. Some 55-80 per cent of respondents perceived no change or improved performance in the six domains of sexual function. CONCLUSION: Almost half of the respondents reported having sexual dysfunction. Although poor pouch function was not identified as an important predictor of sexual dysfunction in this series, larger studies may be required to identify associated prognostic factors clearly.

Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct.

Human tissues that express the angiotensin II (Ang II) type 1 receptor (hAT(1)R) can synthesize four distinct alternatively spliced hAT(1)R mRNA transcripts. In this study, we show that the relative abundance of these mRNA transcripts varies widely in human tissues, suggesting that each splice variant is functionally distinct. Here we demonstrate, for the first time, that the hAT(1)R-B mRNA splice variant encodes a novel long hAT(1)R isoform in vivo that has significantly diminished affinity for Ang II (i.e. >3-fold) when compared with the short hAT(1)R isoform (encoded by hAT(1)R-A mRNA splice variant). This reduced agonist affinity caused a significant shift to the right in the dose-response curve for Ang II-induced inositol trisphosphate production and Ca(2+) mobilization of the long hAT(1)R when compared with that of the short hAT(1)R. The functional differences between these isoforms allows Ang II responsiveness to be fine-tuned by regulating the relative abundance of the long and short hAT(1)R isoform expressed in a given human tissue.

Extension of fusions to the pelvis in idiopathic scoliosis.

STUDY DESIGN: Retrospective study of patients after extension of previous scoliosis fusions to the pelvis. OBJECTIVE: To determine whether modern instrumentation and surgical techniques provide for increased fusion rates with fewer complications. SUMMARY OF BACKGROUND DATA: Traditionally, long fusions to the pelvis in adults with idiopathic scoliosis have resulted in high complication rates, including pseudarthrosis. METHODS: The hospital and clinic charts of 41 patients (40 female, 1 male) were reviewed 41 months (range: 24-116) after surgery for extension to the pelvis of previous scoliosis fusions. Thirty-nine of 41 had a combined anteroposterior fusion extension; two had posterior extension only. In 37 of 41 patients, Cotrel-Dubousset (CD) instrumentation was used; in two, Isola (Acromed Corp., Cleveland, OH), in one, TSRH; (Sofamor-Danek, Memphis, TN), and in one, Synergy (Cross Medical Products, Columbus, OH). Parameters analyzed were fusion rate, sagittal and coronal balance, lumbar lordosis, length of fusion extension, and distal fixation method. RESULTS: Complications were seen in 30 of 41 patients. The pseudarthrosis rate was 37% (15/41) and was significantly related to the method of distal posterior fixation. With sacral fixation only, the rate was 53% (8/15), with iliac fixation only 42% (3/7), and with both iliac and sacral fixation 21% (4/19; P < 0.05). This was not correlated with fusion rate, and the length of fusion extension did not affect the pseudarthrosis rate or sagittal balance. CONCLUSION: When fixed to the ilium and sacrum, modern instrumentation appears capable of maintaining sagittal balance with lower rates of pseudarthrosis when previous scoliosis fusions are extended to the pelvis. The complication rate remains significant.

Lumbar fusion results related to diagnosis.

STUDY DESIGN: Pain outcome and functional outcome after primary lumbar fusion surgery were determined by a self-assessment questionnaire. The responses were correlated with various clinical parameters. OBJECTIVES: To determine the result of fusion surgery among patients in various diagnostic groups using semiquantitative outcome scales. SUMMARY OF BACKGROUND DATA: Most previous studies on the results of primary lumbar fusion have reported the presence of pain, but few have addressed function outcomes. Results of a literature review were inconclusive as to whether a patient's diagnosis is a predictor of improved results. METHODS: During the 3-year period from 1988 to 1990, 165 patients underwent a primary lumbar fusion procedure. They had a chart and radiograph review and were categorized into five major diagnostic groups: 1) pediatric, 2) grade I-II spondylolisthesis (low-slip), 3) grade III-IV spondylolisthesis (high-slip), 4) degenerative disc disease, and 5) postdiscectomy. At a follow-up period of 5 years (mean) after the fusion, patients were mailed a questionnaire in which they described their pain and functional status before and after their lumbar fusion surgery. Questionnaires were returned by 92% of the patients. The questionnaire scores, complications, and revision procedures were grouped by patient diagnosis and analyzed. RESULTS: Patient satisfaction with the results of primary lumbar fusion ranged from 69% (for the postdiscectomy group) to 100% (for the pediatric and high-slip groups). For all diagnostic groups, lumbar fusion resulted in a significant decrease in back pain and leg pain (visual analog scale), which was maintained throughout the follow-up period. For back pain, the pediatric and high-slip groups showed significantly more improvement than the degenerative disc disease or postdiscectomy groups. Leg pain among patients in the pediatric and high-slip groups was significantly more improved than leg pain among patients in the low-slip, degenerative disc disease, or postdiscectomy groups. There was no deterioration of pain scores during the follow-up period. After fusion, all groups had a significant decrease in Oswestry disability scores; patients in the pediatric and high-slip group had significantly more improvement than patients in the degenerative disc disease or postdiscectomy groups. High- and low-slip groups had a significant improvement in their pain drawing score. Medication use was substantially reduced in all groups. After fusion, a lack of improvement in back pain score or disability score was significantly correlated with pseudarthrosis. CONCLUSIONS: The outcome of primary lumbar fusion surgery was decreased pain and increased function for the majority of patients in all five diagnostic categories. The amount of improvement varied by diagnostic group. Patients with developmental conditions showed greater improvement than patients with degenerative conditions.

Vertebral body MRI related to lumbar fusion results.

The evaluation of continued pain after a technically successful posterolateral lumbar spine fusion is often challenging. Although the intervertebral disc is often a source of low back pain, abnormal endplates may also be a focus of pain, and possibly a source of continued pain after a posterolateral fusion. MRI allows noninvasive evaluation for disc degeneration, as well as for abnormal endplates and adjacent vertebral body marrow. Previous studies have found inflammatory marrow changes, adjacent to abnormal endplates, associated with disc degeneration in low back pain patients. In this study, preoperative MRI scans in 89 posterolateral lumbar fusion patients were reviewed, by an independent radiologist, to determine whether vertebral body marrow changes adjacent to the endplates were related to continued pain. Independent chart review and follow-up telephone interview of all patients at a 4-year follow-up (mean) formed the basis for the clinical results. Vertebral body MRI signals consistent with inflammatory or fatty changes were found in 38% of patients, and always occurred adjacent to a degenerated disc. Inflammatory MRI vertebral body changes were significantly related to continued low back pain at P = 0.03. We conclude that posterolateral lumber fusion has a less predictable result for the subset of degenerative disc patients with abnormal endplates and associated marrow inflammation. More research is needed to determine the biological and biomechanical effects of posterolateral fusion upon the endplate within the fused segments. If indeed further study supports the hypothesis that abnormal endplates associated with inflammation are a source of pain, then treating the endplates directly by anterior fusion may be a preferred treatment for this subset of degenerative patients.

Back pain in children and adolescents.

Back pain in children is a common problem that is infrequently reported to physicians. Persistent back pain in children is serious, and most conditions can be diagnosed with relatively simple tests, including diagnostic plain radiographs and bone scans. Many cases, including strains and sprains, are relieved with rest and decreased activity. If persistent back pain, increasing pain, fever, or neurologic deficit is present, referral to the orthopedic surgeon should be swift until a specific cause can be found and treated.

Pelvic fractures after long lumbosacral spine fusions.

STUDY DESIGN: A retrospective review of late pelvic ring fractures after long spine fusions to the lumbosacral spine. OBJECTIVES: To review the clinical course and predisposing features of late fractures of the pelvic ring, usually atraumatic, in patients with long fusions to the lumbosacral spine. SUMMARY OF BACKGROUND DATA: Fractures of the pelvic ring after long fusions to the lumbosacral spine is a heretofore rarely reported complication. METHODS: Records from the authors' institution from 1985 to 1994 were reviewed retrospectively. Two hundred sixty-eight patients with long fusions to the lumbosacrum were identified. RESULTS: Between 1985-1994, five patients suffered late atraumatic fractures of the pelvic ring after long instrumented fusions to L5 or the sacrum. All fractures were on the left side of the pelvic ring, primarily the public rami. All patients were women, and at the time of fracture, all were aged 50 years or older. Fractures occurred from 4 months to 7 years after the last surgery (mean, 28 months). All were treated with protected weightbearing until comfortable. At average 27 months' follow-up evaluation, four patients reported no pain; the fifth had become pain-free at 31 months, but 2 months later, the patient spontaneously fractured the contralateral public rami. CONCLUSION: Stress-type fractures of the pelvic ring are a potential source of late pain after long fusions to the lumbosacral spine. Orthopedic surgeons should be aware of this possibility, especially in older, potentially osteoporotic women. Early treatment with simple protected weightbearing appears satisfactory and can prevent significant morbidity.

An improved technique for measuring in vivo intervertebral motion in the canine.

STUDY DESIGN: An experimental animal study using an established technique for measuring in vivo motion in canines was designed to improve measurement techniques and to eliminate the effects of the instrument mounting technique on the tissue and subsequently on the motion being measured. OBJECTIVES: The purpose of this study was to improve a technique for measuring in vivo intervertebral motion in canines, so that the measuring technique did not affect the motion being measured. SUMMARY OF BACKGROUND DATA: Biplanar radiography has been used to measure in vivo intervertebral motion, but involves radiation exposure and expensive equipment. Electromechanical devices have been used more recently but have had significant effects on the motion over extended time periods. METHODS: Intervertebral motion was measured using an instrumented spatial linkage in eight adult canines divided into two groups that differed regarding the method of "mounting pin" placement. Group I had open surgical placement of the pins and Group II had pins placed into the spinous processes. After pin implantation, the instrumented spatial linkage was attached and motion data were recorded during walking. This testing sequence was repeated 3 weeks later. Animals were killed and intervertebral and facet motion were calculated from the experimental data and compared statistically. RESULTS: Facet motion decreased 1 to 3 weeks after pin implantation for animals of group I (3.4 +/- 0.2 mm to 1.1 +/- 0.3 mm), whereas the facet excursion of animals in Group II showed no change (3.0 +/- 0.2 mm and 3.1 +/- 0.3 mm). CONCLUSIONS: A new method of measuring in vivo intervertebral motion in canines has been developed and shown to have no significant affect on the segment mechanics.

Results of lumbar pseudarthrosis repair.

Forty patients underwent 47 procedures for repair of a lumbar pseudarthrosis at the University of Minnesota, Twin Cities Scoliosis Center between 1973 and 1986. Forty-three procedures in 36 patients with a minimum follow-up of 2 years were reviewed. Symptoms at the time of surgery included back pain (100%), leg pain (61%), subjective neurologic symptoms (49%), and thigh pain (35%). The diagnosis was made most commonly on the basis of pain radiographs (70%). In 38 cases, posterolateral fusion was performed, using segmental sublaminar wiring in 37%, a variable screw plate in 29%, Harrington compression rods in 16%, and no implant in 18%. Anterior interbody fusion was performed in six cases, including one combined fusion. Follow-up averaged 4.4 years. Solid fusion was achieved in 49% of cases. Eighty-six percent of patients continued to have low-back pain. Clinical outcomes were graded as excellent in 7%, good in 35%, fair in 9%, and failure in 49%. Significantly improved results were seen in patients in whom a solid fusion was obtained (p less than 0.005), in patients who had undergone only one prior surgery on the lumbar spine (p less than 0.01), and in patients in whom the initial fusion had been performed for spondylolisthesis rather than a primarily degenerative disorder (p less than 0.025). A trend toward better results was seen in cases in which the patient did not complain of leg pain preoperatively, in which a Workers' Compensation claim was not involved, and in which a prior attempt at pseudarthrosis repair had not been performed.(ABSTRACT TRUNCATED AT 250 WORDS)

Results of spinal arthrodesis with pedicle screw-plate fixation.

Sixty-one patients were followed for an average of thirty months (range, twenty-four to thirty-five months) after arthrodesis of the lumbar or lumbosacral spine with pedicle screw-plate fixation for painful degenerative arthritis, spondylolisthesis, or pseudarthrosis. The patients rated the clinical result according to an analog scale. Most patients reported a marked decrease in pain and an increase in function, and two-thirds were able to work full time. The result of the operation was regarded as a clinical failure if the patient considered it so, if an additional operation had been done, or if the functional and pain scores were not good (that is, if the patient was not able to work full time and the rating for pain was more than 5 of 10 points). Seventeen (28 per cent) of the patients were considered to have a clinical failure, with the lowest rate (20 per cent) for patients who had painful degenerative arthritis and the highest rate (47 per cent) for patients who had had a pseudarthrosis before the operation. The rate of fusion was 90 per cent in patients who had painful degenerative disease, 93 per cent in patients who had spondylolisthesis, and 65 per cent in patients who had had a pseudarthrosis preoperatively.

Surgical treatment of neuropathic spinal arthropathy.

Surgical treatment of neuropathic spinal arthropathy is traditionally associated with a high rate of complication. Ten patients were treated surgically using contemporary techniques of spinal instrumentation and fusion which included combined anterior and posterior procedures when appropriate. The etiology of the spinal arthropathy was fracture (8 patients) and tumor (2 patients). Mean postsurgical follow-up was 4 years. Solid arthrodesis was obtained in eight patients. Our recommendations for surgical treatment include (a) posterior segmental instrumentation and fusion for single level Charcot involvement, with bone grafting of the anterior single level defect accomplished through the posterolateral approach; (b) restoration of normal sagittal plane contour, with anterior first stage surgery recommended for rigid kyphosis or multiple level Charcot involvement; and (c) leaving no intercurrent unfused segments between new and old fusions in the area of neurologic deficit. Fusion to the pelvis is not always necessary but late arthropathy may develop between the fused segment and the pelvis.

Rotational changes of the vertebral-pelvic axis following Cotrel-Dubousset instrumentation.

Ten consecutive patients with adolescent idiopathic scoliosis and King-Moe curve Types II and III, scheduled consecutively for Cotrel-Dubousset instrumentation, underwent pre- and postoperative computed tomography scans with axial slices through each vertebra, and including the pelvis. Vertebral rotation was measured and referenced to the pelvis. Average derotation of the thoracic apex after surgery was 9%. King-Moe Type II curves tended to derotate more successfully (average 26% improvement), while Type III curves derotated very little, if at all (average 1.3% worsening of the rotational deformity). Type II curves often showed segmental rotational changes outside the levels of instrumentation, while Type III curves did not; more frequently the spinal-pelvic axis rotated en bloc. It appears, therefore, that Cotrel-Dubousset instrumentation does not consistently or predictably derotate the thoracic apex relative to the pelvis, and coronal plane correction may only be apparent, due to transmitted torque and rotation of the entire spinal-pelvic axis.

Management of adult spinal deformity with combined anterior-posterior arthrodesis and Luque-Galveston instrumentation.

Twenty-five consecutive adult women with nonparalytic spinal deformity were treated with fusion to the sacrum. Two patients were lost to follow-up and one patient died, leaving 22 patients for review. All patients underwent a first-stage anterior spinal fusion without instrumentation followed by a second-stage posterior spinal fusion with Luque-Galveston instrumentation. The average age of the patients was 47 years (range, 25-64 years). The average follow-up was 39 months (range, 24-60 months). Ten patients had had previous surgery in the area of the instrumentation. The main indications were pain (22 patients), loss of sagittal plane balance (17 patients), and progression of the deformity (13 patients). Additional procedures included anterior corpectomies (five patients), anterior and posterior osteotomies (two patients), posterior osteotomies (eight patients), and posterior decompression (five patients). The average curve correction was 27% for thoracic scoliosis and 44% for lumbar scoliosis. Physiologic sagittal plane realignment was obtained in four patients who presented preoperatively with sagittal plane deformities. Pain improvement was reported in 14 of 22 (63%) patients. Nineteen (82%) patients had 34 complications. Pseudarthrosis occurred in nine patients (41%) and was successfully repaired in four; hence the fusion rate was 77% at follow-up. Of the 23 patients, one died from pulmonary embolism, 15 (66%) were in good condition, one (4%) was in fair condition, and seven (30%) were in poor condition. Previous surgery and additional procedures such as vertebrectomies or osteotomies did not adversely affect the outcome. There were no permanent neurologic deficits related to the instrumentation or the passage of sublaminar wires. The Luque-Galveston method provided correction of sagittal plane deformities and flatback syndrome.

Treatment of adult spinal deformity with fusion to the sacrum using CD instrumentation.

The effectiveness of Cotrel-Dubousset (CD) instrumentation in long fusions to the sacrum for adult spinal deformity was evaluated in 27 consecutive patients. The CD system provided acceptable correction of kyphosis and scoliosis while restoring or maintaining lumbar lordosis. However, the standard CD pelvic fixation using sacral pedicle and alar screws was problematic. Instrumentation-related complications were frequent (70%). Sagittal and frontal plane balance was difficult to achieve and not consistently maintained. The CD system using sacral pedicle and alar screws in the adult patient does not appear to offer advantages over alternative techniques for achieving arthrodesis to the sacrum for adult deformity.

Management of pseudarthrosis after arthrodesis of the spine for idiopathic scoliosis.

Sixty-three first, second, or third-time repairs of one or more pseudarthroses were done in fifty-one patients who had had an arthrodesis for idiopathic scoliosis. Forty-five of the patients were female and six were male. The average age was 30.2 years. The indications for the sixty-three repairs were pain (twenty-five repairs), progression of the curve (sixteen), both pain and progression of the curve (twelve), and radiographic changes only (ten). Failure of the implant was identified before 27 per cent of the sixty-three procedures. The pseudarthroses were diagnosed an average of 2.8 years after the initial arthrodeses. Sixty-eight per cent of the defects were visible on plain radiographs preoperatively and 32 per cent were identified at operation. During the time between the original arthrodeses and the repairs of the pseudarthroses, the scolioses increased by a mean of 7 degrees and the kyphoses, by a mean of 10 degrees. Harrington distraction was the most commonly used instrumentation (twenty-six [41 per cent] of the sixty-three procedures), and autogenous iliac bone was the most commonly used material for the graft (thirty-three [52 per cent] of the procedures).

Epiphysiodesis: two-year clinical results using a new technique.

A new technique for epiphysiodesis was used to treat seven children with lower limb length discrepancies. A low-speed, high-torque drill was used to ablate the epiphyseal plate through a 1-cm incision under image intensification control. Roentgenographically, the physes appeared to be fused as early as 1 month postoperatively. Clinically, growth was arrested at the time of the operation because the discrepancy never became greater than it was at the time of surgery and improved in all cases at subsequent follow-up visits. No failures of fusion, post-operative infections, restricted joint motion, or angular deformities were encountered.