RESUMO
BACKGROUND & AIMS: New York is the current epicenter of Coronavirus disease 2019 (COVID-19) pandemic. The underrepresented minorities, where the prevalence of obesity is higher, appear to be affected disproportionately. Our objectives were to assess the characteristics and early outcomes of patients hospitalized with COVID-19 in the Bronx and investigate whether obesity is associated with worse outcomes independently from age, gender and other comorbidities. METHODS: This retrospective study included the first 200 patients admitted to a tertiary medical center with COVID-19. The electronic medical records were reviewed at least three weeks after admission. The primary endpoint was in-hospital mortality. RESULTS: 200 patients were included (female sex: 102, African American: 102). The median BMI was 30â¯kg/m2. The median age was 64â¯years. Hypertension (76%), hyperlipidemia (46.2%), and diabetes (39.5%) were the three most common comorbidities. Fever (86%), cough (76.5%), and dyspnea (68%) were the three most common symptoms. 24% died during hospitalization (BMIâ¯<â¯25â¯kg/m2: 31.6%, BMI 25-34â¯kg/m2: 17.2%, BMIâ¯≥â¯35â¯kg/m2: 34.8%, pâ¯=â¯0.03). Increasing age (analyzed in quartiles), male sex, BMIâ¯≥â¯35â¯kg/m2 (reference: BMI 25-34â¯kg/m2), heart failure, CAD, and CKD or ESRD were found to have a significant univariate association with mortality. The multivariate analysis demonstrated that BMIâ¯≥â¯35â¯kg/m2 (reference: BMI 25-34â¯kg/m2, OR: 3.78; 95% CI: 1.45-9.83; pâ¯=â¯0.006), male sex (OR: 2.74; 95% CI: 1.25-5.98; pâ¯=â¯0.011) and increasing age (analyzed in quartiles, OR: 1.73; 95% CI: 1.13-2.63; pâ¯=â¯0.011) were independently associated with higher in-hospital mortality. Similarly, age, male sex, BMIâ¯≥â¯35â¯kg/m2 and current or prior smoking were significant predictors for increasing oxygenation requirements in the multivariate analysis, while male sex, age and BMIâ¯≥â¯35â¯kg/m2 were significant predictors in the multivariate analysis for the outcome of intubation. CONCLUSIONS: In this cohort of hospitalized patients with COVID-19 in a minority-predominant population, severe obesity, increasing age, and male sex were independently associated with higher in-hospital mortality and in general worse in-hospital outcomes.