RESUMO
CD10 is known to be expressed in certain types of leukemia, in lymphomas and also in various types of carcinoma. However, data regarding CD10 expression in soft tissue sarcomas is scarce. Two hundred and two retrospective soft tissue sarcoma specimens were evaluated for CD10 expression immunohistochemically. The clinical records of these patients were reviewed, and clinical data was obtained for all patients. Our results showed that 90 of the 202 cases were found to express CD10. 72% of malignant fibrous histiocytomas, 45% of fibrosarcomas, 34% of rhabdomyosarcomas, 50% of leiomyosarcomas, 22% of liposarcomas, 72% of malignant peripheral nerve sheath tumors, and 0% of the primitive neuroectodermal tumors were positive for CD10. Nearly half of the soft tissue sarcomas were found to express CD10. Stronger CD10 expression was found in high grade sarcomas.
Assuntos
Neprilisina/metabolismo , Sarcoma/metabolismo , Neoplasias de Tecidos Moles/metabolismo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Criança , Pré-Escolar , Feminino , Fibrossarcoma/metabolismo , Fibrossarcoma/patologia , Histiocitoma Fibroso Maligno/metabolismo , Histiocitoma Fibroso Maligno/patologia , Humanos , Imuno-Histoquímica , Lactente , Leiomiossarcoma/metabolismo , Leiomiossarcoma/patologia , Lipossarcoma/metabolismo , Lipossarcoma/patologia , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Neprilisina/imunologia , Neoplasias de Bainha Neural/metabolismo , Neoplasias de Bainha Neural/patologia , Tumores Neuroectodérmicos Primitivos/metabolismo , Tumores Neuroectodérmicos Primitivos/patologia , Estudos Retrospectivos , Rabdomiossarcoma/metabolismo , Rabdomiossarcoma/patologia , Sarcoma/patologia , Neoplasias de Tecidos Moles/patologia , Adulto JovemRESUMO
We investigated the difference in the biologic nature of typical squamous cell carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find any significant difference in survival. Our findings indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
Assuntos
Carcinoma Basoescamoso/patologia , Carcinoma de Células Escamosas/patologia , Genes bcl-2 , Neoplasias Laríngeas/patologia , Antígeno Nuclear de Célula em Proliferação/biossíntese , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais , Carcinoma Basoescamoso/imunologia , Carcinoma de Células Escamosas/imunologia , Estudos de Casos e Controles , Humanos , Neoplasias Laríngeas/imunologia , Masculino , Pessoa de Meia-Idade , Projetos PilotoRESUMO
We report two cases of thyroidal plasma cell granuloma. Both patients underwent surgical resection after presenting with painless neck swelling. Histopathologic examination of the specimens revealed plasmacytes infiltrating the thyroid parenchyma and immunohistochemical studies showed the polyclonal nature of the plasma cells. Plasma cell granuloma is a benign lesion and its appearance in the thyroid gland is extremely rare. Eleven prior cases with thyroid localization have been reported to date in the English literature. Nine of the plasma cell granuloma cases occurred in women, four in men (including the present cases). The clinicopathologic features and diagnostic difficulties of this rare entity are described, and its relation to inflammatory pseudotumor of other sites is discussed with a review of the literature.