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1.
J Fish Dis ; 41(7): 1041-1048, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29770449

RESUMO

Monogeneans are ectoparasites that may cause losses in production and productivity in the aquaculture of Colossoma macropomum. Chemotherapeutics used in aquaculture usually have major adverse effects on fish; hence, the use of essential oils has been considered advantageous, but these are not soluble in water. Thus, the use of nanostructures to enhance water solubility of compounds and improve bioactivity may be very promising. This study investigated the antiparasitic activity of nanoemulsion prepared with Copaifera officinalis oleoresin (50, 100, 150, 200 and 300 mg/L), against monogenean parasites from the gills of C. macropomum. The particle size distribution and zeta potential suggested that a potentially kinetic stable system was generated. The nanoemulsion from C. officinalis oleoresin achieved high efficacy (100%) at low concentrations (200 and 300 mg/L) after 15 min of exposure. This was the first time that a nanoemulsion was generated from C. officinalis oleoresin using a solvent-free, non-heating and low-energy method. Moreover, this was the first time that an antiparasitic against monogeneans on fish gills, based on nanoemulsion of C. officinalis oleoresin, was tested.


Assuntos
Antiparasitários/farmacologia , Caraciformes , Fabaceae/química , Extratos Vegetais/farmacologia , Trematódeos/efeitos dos fármacos , Infecções por Trematódeos/veterinária , Animais , Relação Dose-Resposta a Droga , Emulsões , Doenças dos Peixes/tratamento farmacológico , Doenças dos Peixes/parasitologia , Nanoestruturas/análise , Infecções por Trematódeos/tratamento farmacológico , Infecções por Trematódeos/parasitologia
2.
J Fish Dis ; 41(3): 443-449, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29194663

RESUMO

Outbreaks of diseases pose a major threat to sustainable aquaculture development worldwide. Application of herbal products to combat parasitic diseases provides an alternative approach for sustainable aquaculture. This study investigated the in vitro antiparasitic effects of an oil-in-water nanoemulsion prepared using the essential oil from Pterodon emarginatus, against monogeneans infesting Colossoma macropomum. Gill arches from C. macropomum (47.6 ± 14.5 g and 13.5 ± 1.4 cm) that were naturally parasitized by Anacanthorus spathulatus, Notozothecium janauachensis and Mymarothecium boegeri were immersed in different dispersions of the P. emarginatus nanoemulsions (0, 50, 100, 200, 400 and 600 mg/L). The major compounds presented in the essential oil of P. emarginatus were ß-elemene, ß-caryophyllene and α-humulene. Characterization of these nanoemulsions showed that they have a small mean droplet size and low polydispersity index, which is concordant with stable systems. In this in vitro trial, the P. emarginatus nanoemulsion concentrations of 100, 200, 400 and 600 mg/L presented 100% helminthic efficacy against monogeneans of the gills of C. macropomum. The highest two concentrations used (400 and 600 mg/L) were seen to immobilize the parasites after only 15 min. Therefore, it would be worthwhile testing these concentrations in therapeutic baths against monogeneans of C. macropomum.


Assuntos
Anti-Helmínticos/farmacologia , Caraciformes , Fabaceae/química , Doenças dos Peixes/prevenção & controle , Óleos Voláteis/farmacologia , Trematódeos/efeitos dos fármacos , Infecções por Trematódeos/veterinária , Animais , Emulsões , Doenças dos Peixes/parasitologia , Nanoestruturas/análise , Infecções por Trematódeos/parasitologia , Infecções por Trematódeos/prevenção & controle
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