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INTRODUCTION: Hirsutism is a prevalent condition among women and represents a primary clinical feature of polycystic ovary syndrome (PCOS). AREAS COVERED: Our study aims to address the principal challenges associated with this hyperandrogenic manifestation in PCOS women. Our narrative review based on the available indexed literature explored the complexities of establishing mFG cutoff values for various ethnic groups, investigated hirsutism during peri- and postmenopausal stages, and examined the role of oxyandrogens. EXPERT OPINION: Hirsutism may have a negative impact on the quality of life and on the mental health, being associated with anxiety and depression. Future perspectives for its diagnosis include the use of artificial intelligence and the consideration of the distress caused by excessive hair growth.
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Hirsutismo , Síndrome do Ovário Policístico , Feminino , Humanos , Hirsutismo/complicações , Hirsutismo/diagnóstico , Síndrome do Ovário Policístico/complicações , Qualidade de Vida , Inteligência ArtificialRESUMO
OBJECTIVES: To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population. METHODS: This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group. RESULTS: Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer. CONCLUSION: Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease.
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COVID-19 , Adulto , Humanos , Masculino , COVID-19/epidemiologia , Estudos Retrospectivos , SARS-CoV-2 , Hospitalização , Comorbidade , Fatores de Risco , Hospitais , Mortalidade HospitalarRESUMO
Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.
Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease's pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.
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Hirsutismo , Síndrome do Ovário Policístico , Adulto , Negro ou Afro-Americano , Queixo , Feminino , Hirsutismo/epidemiologia , Humanos , PrevalênciaRESUMO
Descrever e analisar a adequação da estrutura e processo das equipes do Programa de Melhoria do Acesso e da Qualidade (PMAQ-AB) na prevenção do câncer de colo de útero na Atenção Básica no Brasil. Métodos: estudo transversal conduzido em todas as unidades básicas de saúde (UBS), entre 2012 e 2013. Estimou-se a prevalência da adequação da estrutura (insumos/materiais) e do processo de trabalho para o exame de Papanicolau. A associação da adequação com características das unidades e equipes foi estimada pela razão de prevalência (RP) e intervalos de confiança de 95 por cento (IC95 por cento). Resultados: foram estudadas 38.812 UBS e 17.202 equipes de saúde. A prevalência de adequação da estrutura e do processo de trabalho foi 49 por cento e 30 por cento, respectivamente. A adequação da estrutura e o processo estiveram associados ao maior porte do município e IDH. A prevalência de adequação da estrutura foi maior nas unidades da Estratégia de Saúde da Família (RP=1,35; IC95 por cento:1,33-1,38), cuja adequação do processo de trabalho esteve associada à população adscrita <4.000 pessoas e equipe mínima completa. Conclusões: a estrutura e o processo de trabalho para o rastreamento do câncer de colo uterino necessitam ser aprimoradas. As equipes de saúde carecem de maior qualificação das ações relacionadas a esta ação programática...
To outline and examine the adequacy of the structure and processes used by Access and Quality Improvement Program (PMAQ-AB) teams to prevent cervical cancer during basic care in Brazil. Methods: a cross-sectional study was carried out at all basic health units (BHUs), between 2012 and 2013. The prevalence of adequate structure (infrastructure and materials) and working processes for conducting the Pap test was calculated. The association of adequacy with characteristics of the units and their teams were measured using the prevalence ratio (PR) and confidence intervals of 95 percent (CI95 percent). Results: 38,812 BHUs and 17,202 healthcare teams were studied. The prevalence of adequate structure and working processes was 49 percent and 30 percent, respectively. The adequacy of structure and processes was associated positively with largely size of municipality and higher HDI. The prevalence of adequate structure was higher at units adopting the Family Health Strategy (PR=1.35; CI95 percent: 1.33-1.38) and the adequacy of their working processes was associated with having a registered population of <4,000 individuals and full minimal team. Conclusions: the structure and processes used to screen for cervical cancer need to be improved. Healthcare teams need to provide better quality intervention in relation to this program...