Tonsillar lymphoma masquerading as obstructive sleep apnea - pediatric case report.

The commonest cause of head and neck malignancy in pediatric patients is lymphoma. A particular case is the tonsillar lymphoma. Even though unilateral tonsillar enlargement represents an ominous sign for neoplasia, clinical manifestations vary and are non-specific. Therefore, a delayed diagnosis is performed which compromises optimal therapy and hinders the prognosis. We present the case of a 5-year-old boy who was initially diagnosed with obstructive sleep apnea, without reported systemic complaints. Asymmetric tonsillar hypertrophy created the premises for performing a tonsillectomy to rule out malignancy. The pathological evaluation of the resected tonsils revealed a malignant non-Hodgkin's lymphoma, with immunophenotypic features consistent with sporadic type Burkitt lymphoma. The aim of this paper is to emphasize the importance of the histopathological examination and of the immunohistochemistry testing for the prompt and accurate diagnosis of all asymmetric tonsillar hypertrophy in children undergoing tonsillectomy. Furthermore, immunohistochemical diagnosis is vital for establishing a personalized multi-agent chemotherapy regimen, which dramatically improves the survival rate. We recommend histopathological evaluation in all children with asymmetric tonsillar hypertrophy undergoing tonsillectomy for various reasons. Needless to say, it is better to be cautious and exclude the presence of tonsillar lymphoma, than to confront with the severe consequences of misdiagnosis.

Diagnostic techniques for organic foreign body aspiration in children ­ case reports.

Tracheobronchial foreign body aspiration represents a life-threatening condition especially in young children. It carries a great amount of mortality and morbidity through the possibility of obstructing the airway and thus resulting in acute respiratory failure. The diagnostic challenges are brought by the great variability of clinical presentation which sometimes only consists of subtle symptoms. For an optimal therapeutic outcome, only a high index of clinical suspicion can ensure a prompt treatment. The mainstay of both diagnostic and therapeutic algorithm resides in bronchoscopy. The article reports the multidisciplinary management of two young children with organic foreign body aspiration, outlining the importance of a step-wise diagnostic approach.

A Self Organizing Map approach to breast cancer detection.

Detection and characterization of cancer tumors in mammograms is vital in daily clinical practice. The problem of detecting possible cancer areas is very complex due, on one hand, to the diversity in shape of the ill tissue and on the other hand to the poorly defined border between the healthy and the cancerous zone. Even though it has been studied for many years, there are still remaining challenges and directions for future research such as developing better enhancement and segmentation algorithms. The performance of the Self Organizing Map (SOM) in detecting the cancer suspicious regions in digitized mammograms is revealed in this study. In order to achieve the best results we firstly apply the preprocessing algorithms proposed in section II of the study.