Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Pomadas/administração & dosagem , Seio Pilonidal/cirurgia , Cicatrização/efeitos dos fármacos , Administração Tópica , Adolescente , Adulto , Alginatos/administração & dosagem , Aloe , Colostro , Feminino , Glicerol/administração & dosagem , Humanos , Ácido Hialurônico/administração & dosagem , Itália , Masculino , Pessoa de Meia-Idade , Pomadas/química , Período Pós-Operatório , Resultado do Tratamento , Adulto JovemAssuntos
Apolipoproteínas A/sangue , Apolipoproteínas B/sangue , Bezafibrato/uso terapêutico , Hiperlipoproteinemia Tipo II/tratamento farmacológico , Lipoproteínas/sangue , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , VLDL-Colesterol/sangue , Avaliação de Medicamentos , Feminino , Humanos , Hiperlipoproteinemia Tipo II/sangue , Masculino , Pessoa de Meia-Idade , Triglicerídeos/sangueRESUMO
Human natural killer (NK) cell activity, as measured against K-562 target cells, was evaluated in 23 untreated and in 11 bromocriptine-treated hyperprolactinemic female patients and in 63 age-matched healthy women using 51Cr-release assay. The NK cell activity was significantly reduced in untreated hyperprolactinemic patients with respect to that of normal subjects, but therapy with bromocriptine restored NK cell function of patients to the levels of normal controls. Moreover, a reduced number of Leu-7+ cells and of large granular lymphocytes in hyperprolactinemic patients, as compared to normal controls and bromocriptine-treated subjects, correlated well with the decreased NK activity. Finally, 'in vitro' incubation with purified human prolactin, did not affect NK cell activity of blood mononuclear cells. The present results demonstrate that pathological hyperprolactinemia, in which a tuberoinfundibular dopaminergic defect has been postulated, is also associated with a reduction in NK cell number and function and indicate a possible interaction between prolactin, neuroendocrine system and NK cell lineage in man.
Assuntos
Citotoxicidade Imunológica , Hiperprolactinemia/imunologia , Células Matadoras Naturais/imunologia , Antígenos de Diferenciação de Linfócitos T , Antígenos de Superfície/análise , Bromocriptina/uso terapêutico , Citotoxicidade Imunológica/efeitos dos fármacos , Feminino , Humanos , Hiperprolactinemia/tratamento farmacológico , Contagem de Leucócitos , Prolactina/farmacologiaRESUMO
74 operations for the removal of calcaneal spurs at the "G. Pini" Orthopaedic Clinic in Milan over the post 20 years have been examined. After a brief summary of the main aetiopathogenetic theories, the symptomatological picture and various surgical techniques, and the data on the cases encountered are analysed. A high percentage of failures is reported. It is hoped that all cases of talalgia due to calcaneal spur will initially be given conservative therapy. Only if this fails should surgery be considered.