Venous Thromboembolism in Metastatic Uterine Leiomyosarcoma: A Case Report and Review of the Literature.

We report an unusual case of extensive deep vein thrombosis (DVT) and pulmonary embolism (PE) in the setting of metastatic uterine leiomyosarcoma. Recognition of the associated sequelae of this condition may improve short- and long-term outcomes. A 56-year-old black female with a history of uterine leiomyosarcoma diagnosed incidentally after total abdominal hysterectomy for fibroid uterus without initiation of chemoradiation treatment presented to the emergency department complaining of generalized weakness and progressively worsening stridor for 2 weeks. The patient was experiencing shortness of breath, dysphagia, and hoarseness. Physical exam was remarkable for rhonchi but was otherwise normal. Diagnostic imaging via CT of the abdomen, pelvis, and chest revealed DVTs of the left common and external iliac veins, the superior mesenteric artery, multiple pulmonary emboli of the right pulmonary artery, several nodular lesions within the lungs, and scattered peritoneal necrotic lesions, which were suspicious for metastatic disease. Additionally, CT of the neck showed an exophytic mass protruding into the airway from the subglottic region and thyromegaly with bilateral thyroid lobe nodules. The patient was subsequently started on Eliquis and chemotherapy. The rarity of this case is rooted in the extent of the patient's DVTs and PEs secondary to hypercoagulability in metastatic cancer. This presentation should be further evaluated to exclude thrombophilias or underlying malignancies. Drawing from the lessons of this case will help guide future clinical management regarding the care of metastatic uterine leiomyosarcoma.

Extended BODIPYs as Red-NIR Laser Radiation Sources with Emission from 610 nm to 750 nm.

Herein, we report the synthetic access to a set of π-extended BODIPYs featuring a penta-arylated (phenyl and/or thiophene) dipyrrin framework. We take advantage of the full chemoselective control of 8-methylthio-2,3,5,6-tetrabromoBODIPY when we conduct the Liebeskind-Srogl cross-coupling (LSCC) to functionalize exclusively the meso-position, followed by the tetra-Suzuki reaction to arylate the halogenated sites. All these laser dyes display absorption and emission bands in the red edge of the visible spectrum reaching the near-infrared with thiophene functionalization. The emission efficiency, both fluorescence and laser, of the polyphenylBODIPYs can be enhanced upon decoration of the peripheral phenyls with electron donor/acceptor groups at para positions. Alternatively, the polythiopheneBODIPYs show an astonishing laser performance despite the charge transfer character of the emitting state. Therefore, these BODIPYs are suitable as a palette of stable and bright laser sources covering the spectral region from 610 nm to 750 nm.

Modelo explicativo y predittivo de la ideación suicida en una muestra de bachilleres mexicanos / Explicative and predictive model of suicide ideation in a sample of mexican high school students

Resumen La presente investigación se planteó como objetivo principal elaborar un modelo explicativo y predictivo de ideación suicida en estudiantes de un bachillerato mexicano. Los participantes del estudio fueron estudiantes de tres carreras técnicas de una institución de educación pública del estado de Jalisco, México. La muestra estuvo compuesta por 911 alumnos, seleccionados a través de un muestreo no probabilístico. Las variables exógenas que se contemplaron fueron el sexo, el apoyo social percibido, el ajuste y la victimización escolar, la conducta alimentaria de riesgo, la insatisfacción con la imagen corporal y la depresión. El instrumento para medir la ideación suicida fue la escala de ideación suicida desarrollada por Beck, Kovacs y Weissman, la cual mide las diversas características y la frecuencia de pensamientos y actitudes referentes a la intencionalidad de cometer suicidio. Mediante un análisis de regresión lineal múltiple se construyó un modelo explicativo y predictivo de ideación suicida que incluyó las variables de depresión, apoyo familiar y problemas de ajuste a la escuela. A partir de los hallazgos se sugiere desarrollar estrategias de intervención en el contexto escolar y familiar que se enfoquen, de manera primordial, a las variables que predicen un aumento significativo de la ideación suicida.

Abstract The objective of this research was to develop an explicative and predictive model of suicidal ideation in Mexican high school students. The study participants were students of three technical careers from a public education institution in the state of Jalisco, Mexico. The sample consisted of 911 students, selected through non-probabilistic sampling. The exogenous variables were sex, social support, adjustment and school victimization, risky eating behavior, dissatisfaction with body image and depression. The instrument for measuring suicidal ideation was the "Suicidal Ideation Scale" developed by Beck, Kovacs and Weissman which measures the characteristics and frequency of thoughts and attitudes about the intentionality of committing suicide. An explicative and predictive model of suicidal ideation was constructed that included the variables of depression, family support and adjustment problems to the school through a Multiple Linear Regression analysis. Based on the findings, it is suggested to develop intervention strategies within the school and family context focused on the variables that predict a significant increase in suicidal ideation.