RESUMO
Superficial acral fibromyxoma, also known as digital fibromyxoma, is a benign soft tissue tumor. The acral regions, including the palms, soles, fingers, toes, and nail units, are the commonly affected locations. The subungual region of the great toe is the most common site reported in current literature. The tumor is slowly progressive and benign in nature. Histology commonly reveals a fibromyxoid neoplasm with immunoreactivity to CD34 and CD99 markers.1,2,3 We present the case of a 39-year-old female with a nine-year history of repetitive digital trauma presenting with superficial acral fibromyxoma of the thumb-nail bed. Our case is unique due to the tumor location and the patient's prior long history of trauma to the tumor site.
Assuntos
Fibroma , Polegar , Feminino , Humanos , Adulto , DedosRESUMO
Bloodroot (Sanguinaria canadensis) is a plant that historically has been used in medicine for its antimicrobial, antihypertensive, anti-inflammatory, and antineoplastic properties. In dermatology, bloodroot has been utilized for its cytotoxic effects; it has been marketed as black salve as an anticancer treatment, but it does not come without notable toxicities. Unwanted cosmetic outcomes and even irreversible scarring and premalignant conditions have been reported. This article aims to bring awareness to both the therapeutic potential of S canadensis as well as the potential toxicities and risks associated with this North American plant.
Assuntos
Antineoplásicos , Sanguinaria , Humanos , Pomadas , Extratos VegetaisAssuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Angiomatose Bacilar/microbiologia , Bartonella/isolamento & purificação , Infecções por HIV/imunologia , Hospedeiro Imunocomprometido , Pele/microbiologia , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Infecções Oportunistas Relacionadas com a AIDS/imunologia , Infecções Oportunistas Relacionadas com a AIDS/patologia , Angiomatose Bacilar/tratamento farmacológico , Angiomatose Bacilar/imunologia , Angiomatose Bacilar/patologia , Antibacterianos/uso terapêutico , Bartonella/efeitos dos fármacos , Biópsia , Infecções por HIV/diagnóstico , Humanos , Masculino , Pele/efeitos dos fármacos , Pele/patologia , Resultado do Tratamento , Adulto JovemRESUMO
Supernumerary breasts and nipples are not uncommon and have familial and syndrome associations. Although usually of only cosmetic concern, hormonal changes and inflammatory or neoplastic conditions that affect primary breast tissue also may occur in areas of ectopic breast tissue. We describe cases of familial functional axillary breasts and primary carcinoma of the breast arising in ectopic axillary breast tissue.
Assuntos
Neoplasias da Mama/patologia , Mama , Coristoma/patologia , Mamilos , Mama/anormalidades , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Mamilos/anormalidadesRESUMO
The literature on cutaneous metastatic disease can be difficult to interpret because of inconsistent study design and analysis among authors. Furthermore, one should be careful when reviewing the statistics in the literature, as reported patient populations tend to vary and are not representative of the whole population. However, certain trends are notable and should be reported. Diagnosis of cutaneous metastatic disease carries a grave prognosis. We describe a patient with pulmonary cutaneous metastasis and provide a review of the literature on nonmelanomatous solid tumor malignancies that most commonly have cutaneous metastases. The review will focus on epidemiology, clinical presentation, histology and immunohistochemical staining, and prognosis and management. The most common cutaneous metastasizing carcinomas--breast, lung, and colorectal cancer--also are discussed.
Assuntos
Adenocarcinoma/secundário , Carcinoma Pulmonar de Células não Pequenas/patologia , Neoplasias Pulmonares/patologia , Neoplasias Cutâneas/secundário , Neoplasias Encefálicas/secundário , Evolução Fatal , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
Viral-associated trichodysplasia is a recently described entity associated with immunosuppression. We describe a 68-year-old man with a history of treated lymphoma who developed numerous, disfiguring, papular and spiny lesions involving most of the central face. Both facial and body alopecia was noted. Histopathologic findings of a facial papule showed dramatic alterations of the hair bulbs, including bulbar distention, lack of hair shaft formation and a marked expansion of inner root sheath type epithelium. These findings were identical to those of previously described cases, so electron microscopy was performed. Numerous intranuclear virus particles were identified. Shortly after the diagnosis of trichodysplasia was made, the patient was found to have a relapse of his lymphoma, which may represent the source of his immunosuppression. Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study.
Assuntos
Dermatoses Faciais/virologia , Doenças do Cabelo/virologia , Folículo Piloso/virologia , Linfoma não Hodgkin/complicações , Administração Tópica , Idoso , Alopecia/etiologia , Alopecia/patologia , Antivirais/uso terapêutico , Cidofovir , Citosina/análogos & derivados , Citosina/uso terapêutico , Dermatoses Faciais/patologia , Doenças do Cabelo/patologia , Folículo Piloso/ultraestrutura , Humanos , Corpos de Inclusão Viral/ultraestrutura , Corpos de Inclusão Intranuclear/ultraestrutura , Masculino , Organofosfonatos/uso terapêutico , Polyomavirus/ultraestrutura , Resultado do TratamentoRESUMO
Patients may seek "alternative" or "non-traditional" therapies for dermatologic problems, frequently in search of a miraculous cure. However, many of these medicaments contain unknown compounds with questionable benefit and a potential for significant harm. We describe a patient who developed a large ulceration on her nose after applying "black and yellow salves" obtained from Mexico in an attempt to self-treat a basal cell carcinoma.
Assuntos
Carcinoma Basocelular/tratamento farmacológico , Terapias Complementares , Neoplasias Nasais/tratamento farmacológico , Pomadas , Neoplasias Cutâneas/tratamento farmacológico , Úlcera Cutânea/induzido quimicamente , Idoso , Feminino , Humanos , Automedicação/efeitos adversosRESUMO
Plantar keloids are a management problem as a result of the pain and mechanic restriction with ambulation. We present the treatment of a patient with a particularly large plantar keloid that was refractory to multiple excisions, adjunctive intralesional steroids, and radiation therapy, who was successfully treated with excision, intralesional steroids, and tissue-engineered allograft placement.