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1.
World Neurosurg ; 164: 178-198, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35552036

RESUMO

Benign tumors that grow in the spinal canal are heterogeneous neoplasms with low incidence; from these, meningiomas and nerve sheath tumors (neurofibromas and schwannomas) account for 60%-70% of all primary spinal tumors. Benign spinal canal tumors provoke nonspecific clinical manifestations, mostly related to the affected level of the spinal cord. These tumors present a challenge for the patient and healthcare professionals, for they are often difficult to diagnose and the high frequency of posttreatment complications. In this review, we describe the epidemiology, risk factors, clinical features, diagnosis, histopathology, molecular biology, and treatment of extramedullary benign meningiomas, osteoid osteomas, osteoblastomas, aneurysmal bone cysts, osteochondromas, neurofibromas, giant cell tumors of the bone, eosinophilic granulomas, hemangiomas, lipomas, and schwannomas located in the spine, as well as possible future targets that could lead to an improvement in their management.


Assuntos
Neoplasias Meníngeas , Meningioma , Neurilemoma , Neurofibroma , Neurofibromatoses , Neoplasias da Medula Espinal , Neoplasias da Coluna Vertebral , Humanos , Canal Medular/patologia , Neoplasias da Medula Espinal/patologia , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Neoplasias da Coluna Vertebral/epidemiologia , Neoplasias da Coluna Vertebral/cirurgia
2.
J Bone Miner Res ; 32(9): 1853-1859, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28543917

RESUMO

Congenital disorders of glycosylation (CDGs) affect multiple systems and present a broad spectrum of clinical features, often including skeletal dysplasia. Exome sequencing has led to the identification of new CDG genes. Immune and skeletal phenotypes associated with mutations in PGM3, encoding a protein that converts N-acetyl-glucosamine-6-phosphate into N-acetyl-glucosamine-1-phosphate, were recently reported. Through exome sequencing, we identified a novel homozygous mutation (c.1135T>C; p.Phe379Leu) in PGM3 in two siblings with bone marrow failure, severe combined immunodeficiency, renal and intestinal malformations, and a skeletal dysplasia resembling Desbuquois dysplasia. Severe respiratory compromise secondary to lung hypoplasia and pulmonary hypertension, and intestinal obstruction led to their demise. We thus report the most severe phenotype described so far associated with PGM3 mutations. This CDG should be considered in the presence of skeletal dysplasia associated with severe immunodeficiency. © 2017 American Society for Bone and Mineral Research.


Assuntos
Doenças do Desenvolvimento Ósseo/genética , Doenças da Medula Óssea/genética , Anormalidades Musculoesqueléticas/genética , Mutação , Fosfoglucomutase/genética , Imunodeficiência Combinada Severa/genética , Feminino , Humanos , Recém-Nascido , Masculino
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