1.
Zh Nevrol Psikhiatr Im S S Korsakova
; 119(10. Vyp. 2): 14-20, 2019.
Artigo
em Russo
| MEDLINE
| ID: mdl-31934984
RESUMO
The immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α) is involved in the regulation of both physiological and pathological processes in the central nervous system (CNS). The effects of TNF-α on CNS reported in clinical trials and experimental studies, evidence of involvement of this cytokine in the pathogenesis of multiple sclerosis are analyzed. Possible causes of failures of non-selective pharmacological inhibition of TNF-α effects in MS are considered in view of current concepts on mechanisms of TNF-α action.