RESUMO
A new 2H-tetrahydropyran derivative, 6-epi-goniothalesdiol A (1), together with nine known styryllactones (2-10) and five known aristolactams (11-15) were isolated from the bark of Goniothalamus elegants Ast. The structures were elucidated by spectroscopic methods. The isolated compounds were evaluated for their cytotoxicity toward the KB, MCF7 and NCI-H187 cell lines as well as antimalarial and antimycobacterial activities. Compounds 4 and 10 showed strong activity against all three human cancer cell lines with IC50 values in the range of 0.538 to 4.25 µg/ml, while compounds 2, 4, 10 and 14 showed potent cytotoxicity against NCI-H187 with IC50 values in the range of 0.072 to 2.17 µg/ml. In addition, compounds 4, 6, 7, 9, 10 and 13 showed strong antiplasmodial activity with IC50 in the range of 2.28 to 5.89 µg/ml.
Assuntos
Antimaláricos/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Furanos/farmacologia , Goniothalamus/química , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antimaláricos/isolamento & purificação , Antineoplásicos Fitogênicos/isolamento & purificação , Linhagem Celular Tumoral , Furanos/isolamento & purificação , Humanos , Concentração Inibidora 50 , Estrutura Molecular , Casca de Planta/químicaRESUMO
Two new angular types of azaphilones, isochromophilonol (1) and ochrephilonol (2), together with ten known compounds (3-12), were isolated from Chaetomium cupreum RY202. Their structures were established on the basis of spectroscopic data and the absolute configurations of 1 and 3 were determined by the modified Mosher's method. Compounds 1, 2 and 4 showed moderated cytotoxicity against KB and NCI-H187 cell lines (IC50 9.63-32.42 µg/mL).
Assuntos
Chaetomium/química , Chaetomium/isolamento & purificação , Linhagem Celular Tumoral , Humanos , Células MCF-7RESUMO
Four new azaphilones named longirostrerones A-D (1-4) and three known sterols, ergosteryl palmitate, ergosterol, and ergosterol peroxide, have been isolated from ethyl acetate extract of the fungus Chaetomium longirostre. These structures were determined by 1D and 2D NMR, IR, UV, MS, and CD spectroscopy. Compounds 1-4 exhibited strong cytotoxicity against KB cancer cell lines (IC(50) 0.23-6.38 µM), while only 1 showed potent cytotoxicity against MCF7 and NCI-H187 cell lines (IC50 0.24 and 3.08 µM, respectively). In addition, 1-3 showed antimalarial activity against Plasmodium falciparum (IC50 0.62-3.73 µM).