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Reprod Toxicol ; 86: 86-97, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31028817

RESUMO

The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (C♀-C♂), BPA dam -Control sire (B♀-C♂), Control dam -BPA sire (C♀-B♂), BPA dam -BPA sire (B♀-B♂). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the B♀-B♂ group as compared to the C♀-C♂ group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreased progesterone serum levels.


Assuntos
Compostos Benzidrílicos/toxicidade , Caderinas/metabolismo , Implantação do Embrião/efeitos dos fármacos , Troca Materno-Fetal , Ocludina/metabolismo , Fenóis/toxicidade , Talina/metabolismo , Animais , Estradiol/sangue , Feminino , Masculino , Gravidez , Progesterona/sangue , Ratos Wistar , Útero/efeitos dos fármacos , Útero/metabolismo
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