Assuntos
Insulinoma/patologia , Neoplasia Endócrina Múltipla Tipo 1 , Pancreatectomia/métodos , Neoplasias Pancreáticas , Hipófise/diagnóstico por imagem , Neoplasias Hipofisárias/patologia , Adenoma de Células das Ilhotas Pancreáticas/patologia , Adulto , Tratamento Conservador , Diagnóstico Diferencial , Feminino , Humanos , Neoplasia Endócrina Múltipla Tipo 1/diagnóstico , Neoplasia Endócrina Múltipla Tipo 1/patologia , Neoplasia Endócrina Múltipla Tipo 1/terapia , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/cirurgia , Administração dos Cuidados ao Paciente/métodos , Tomografia Computadorizada por Raios X/métodosRESUMO
Under study were catalase activity and indicators of lipid peroxidation (LP) of donor blood exposed to different doses of UV irradiation. Doses lower than 630 J/m2 were found to activate catalase and to inhibit LP while doses higher than 630 J/m2 inhibited catalase activity and activated LP. The indicators of LP have confirmed that therapeutic doses of UV-irradiated blood were nontoxic. The most optimal therapeutic dose of irradiation (630 J/m2) was determined.
Assuntos
Doadores de Sangue , Catalase/efeitos da radiação , Peroxidação de Lipídeos/efeitos da radiação , Raios Ultravioleta , Adulto , Sangue/efeitos da radiação , Transfusão de Sangue Autóloga , Catalase/sangue , Relação Dose-Resposta à Radiação , Humanos , Lipídeos/sangue , Lipídeos/efeitos da radiação , Terapia UltravioletaRESUMO
The results of complex treatment of 81 patients with pyoinflammatory diseases with the use of blood ultraviolet irradiation are discussed. A marked clinical effect was noted, the terms of treatment reduced by 5-10 days, the outcomes improved, and the number of complications decreased. Irradiation of autologous blood by ultraviolet rays led to modulation of the indices of antimicrobial protection, increase of the intensity of the histochemical reaction to peroxidase up to 40-50%, and diminution of pH in the neutrophil phagosomes to 5.0. The ultrastructure and ability of thrombocytes to store serotonin were restored, and intensity of their metabolic processes increased, the membrane phospholipid composition changed, and juvenile platelet forms appeared.