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Viruses ; 16(4)2024 03 31.
Artigo em Inglês | MEDLINE | ID: mdl-38675891

RESUMO

Swine influenza A viruses pose a public health concern as novel and circulating strains occasionally spill over into human hosts, with the potential to cause disease. Crucial to preempting these events is the use of a threat assessment framework for human populations. However, established guidelines do not specify which animal models or in vitro substrates should be used. We completed an assessment of a contemporary swine influenza isolate, A/swine/GA/A27480/2019 (H1N2), using animal models and human cell substrates. Infection studies in vivo revealed high replicative ability and a pathogenic phenotype in the swine host, with replication corresponding to a complementary study performed in swine primary respiratory epithelial cells. However, replication was limited in human primary cell substrates. This contrasted with our findings in the Calu-3 cell line, which demonstrated a replication profile on par with the 2009 pandemic H1N1 virus. These data suggest that the selection of models is important for meaningful risk assessment.


Assuntos
Vírus da Influenza A Subtipo H1N1 , Influenza Humana , Infecções por Orthomyxoviridae , Replicação Viral , Animais , Suínos , Infecções por Orthomyxoviridae/virologia , Humanos , Medição de Risco , Influenza Humana/virologia , Influenza Humana/epidemiologia , Linhagem Celular , Vírus da Influenza A Subtipo H1N1/fisiologia , Doenças dos Suínos/virologia , Modelos Animais de Doenças , Vírus da Influenza A Subtipo H1N2/genética , Pandemias , Camundongos , Cães , Células Epiteliais/virologia , Feminino
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