RESUMO
Inflammatory myofibroblastic tumor is a neoplasm of intermediate biological potential, a marked inflammatory component, and characteristic genetic changes. Once it was identified as an independent nosological entity from a rather heterogeneous group of inflammatory pseudotumors. This paper describes a case of inflammatory myofibroblastic tumor of the chest in a child, by discussing the criteria for differential diagnosis in the use of up-to-date radiology techniques. When thoracic neoplasms are detected, it is necessary to determine their site and the most likely origin organ as exactly as possible and to assess the X-ray pattern of the pathological process. By applying the state-of-the-art radiodiagnostic techniques, the clarification of the pattern of the disease makes it possible to choose an optimal treatment policy and a surgical procedure and scope, to avoid anesthesia overload, and to decrease the probability of resurgery. Our observation is to demonstrate possible problems in the diagnosis of inflammatory myofibroblastic tumor of the lung in childhood and to recall again the algorithm of radiological approaches to detecting mediastinal and lung masses.
Assuntos
Neoplasias Pulmonares , Pulmão/diagnóstico por imagem , Neoplasias do Mediastino , Neoplasias de Tecido Muscular , Pneumonectomia , Complicações Pós-Operatórias/prevenção & controle , Angiografia/métodos , Biópsia , Criança , Diagnóstico Diferencial , Feminino , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/fisiopatologia , Granuloma de Células Plasmáticas/cirurgia , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/fisiopatologia , Neoplasias Pulmonares/cirurgia , Neoplasias do Mediastino/patologia , Neoplasias do Mediastino/fisiopatologia , Neoplasias do Mediastino/cirurgia , Invasividade Neoplásica , Neoplasias de Tecido Muscular/patologia , Neoplasias de Tecido Muscular/fisiopatologia , Neoplasias de Tecido Muscular/cirurgia , Pneumonectomia/efeitos adversos , Pneumonectomia/métodos , Intensificação de Imagem Radiográfica/métodos , Tomografia Computadorizada Espiral/métodos , Resultado do TratamentoRESUMO
Neonatal interstitial emphysema (IE) may develop as a complication of the respiratory distress syndrome. IE is classified as acute and persistent and as diffuse and local forms. The differential diagnosis of persistent IE and congenital cystic malformations from clinical and imaging data may present problems. The histological pattern of persistent IE has specific features that permit the morphological diagnosis of this condition.
Assuntos
Enfisema Pulmonar/diagnóstico , Enfisema Pulmonar/patologia , Síndrome do Desconforto Respiratório do Recém-Nascido/diagnóstico , Síndrome do Desconforto Respiratório do Recém-Nascido/patologia , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Recém-Nascido , MasculinoRESUMO
There may be a number of tumors made up by small round blue cells in the kidneys of children. One of them is primitive neuroectodermal tumor (PNET). The differences in therapeutic approaches determine the need to establish an accurate diagnosis. The differential diagnosis of PNET and the blastemal component of Wilms tumor can be difficult due to the similar histological pattern. There is a need for a close analysis of morphological manifestations, by keeping in mind the age of patients, and supplementary studies. A strong CD99 membrane expression and nuclear FLI1 expression in tumor cells are the signs of PNET. Reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization can determine PNET-specific translocations [t(11;22)(q24;q12), by involving the EWS gene.
Assuntos
Neoplasias Renais/diagnóstico , Tumores Neuroectodérmicos Primitivos/diagnóstico , Tumor de Wilms/diagnóstico , Antígeno 12E7 , Antígenos CD/biossíntese , Antígenos CD/genética , Moléculas de Adesão Celular/biossíntese , Moléculas de Adesão Celular/genética , Criança , Pré-Escolar , Cromossomos Humanos Par 11/genética , Cromossomos Humanos Par 11/metabolismo , Cromossomos Humanos Par 22/genética , Cromossomos Humanos Par 22/metabolismo , Diagnóstico Diferencial , Feminino , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Neoplasias Renais/genética , Neoplasias Renais/metabolismo , Neoplasias Renais/patologia , Masculino , Tumores Neuroectodérmicos Primitivos/genética , Tumores Neuroectodérmicos Primitivos/metabolismo , Tumores Neuroectodérmicos Primitivos/patologia , Proteína Proto-Oncogênica c-fli-1/biossíntese , Proteína Proto-Oncogênica c-fli-1/genética , Proteína EWS de Ligação a RNA/biossíntese , Proteína EWS de Ligação a RNA/genética , Translocação Genética/genética , Tumor de Wilms/genética , Tumor de Wilms/metabolismo , Tumor de Wilms/patologiaRESUMO
Solitary orbital fibrous tumor was diagnosed in a 12-year old boy admitted to hospital for right-sided exophthalmos. MRI revealed orbital mass and surgical resection was performed. Histologically the tumor was composed of round or spindle cells with a lot of multinucleate giant cells and pseudovascular spaces. The neoplasm was regarded as a mixoid type of a solitary giant cell-rich fibrous tumor. Immunohistochemical analysis revealed coexpression of CD34, CD99, bcl-2, and CD99 (mic-2). The most important clinical, morphological, and immunohistochemical manifestations are presented in the paper. Major criteria for the differential diagnosis of solitary orbital fibrous tumor and the similar soft tissue tumors are discussed.
Assuntos
Tumores de Células Gigantes/patologia , Neoplasias de Tecido Fibroso/patologia , Neoplasias Orbitárias/patologia , Antígenos CD/biossíntese , Biomarcadores Tumorais/biossíntese , Criança , Diagnóstico Diferencial , Tumores de Células Gigantes/diagnóstico por imagem , Tumores de Células Gigantes/metabolismo , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética , Masculino , Neoplasias de Tecido Fibroso/diagnóstico por imagem , Neoplasias de Tecido Fibroso/metabolismo , Neoplasias Orbitárias/diagnóstico por imagem , Neoplasias Orbitárias/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/biossíntese , RadiografiaRESUMO
A morphological study of renal tumors in children requires the accurate diagnosis of the histological type and stage of a tumor and the evaluation of its risk in accordance with the SIOP protocol standards. Pathological findings may provide the most adequate therapeutic approach in every specific case. It is necessary to correctly analyze the results of studies and to elaborate the most effective and adequate treatment
Assuntos
Neoplasias Renais/classificação , Neoplasias Renais/patologia , Tumor de Wilms/classificação , Tumor de Wilms/patologia , Criança , Diagnóstico Diferencial , Humanos , Neoplasias Renais/terapia , Estadiamento de Neoplasias/métodos , Tumor de Wilms/terapiaRESUMO
Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphism and high mitotic index (more than 4 mitoses within 4 visual fields, at high magnification) were used as malignancy criteria:. Tumor histological pattern of "hemangiopericytic" variety could be reliably identified thanks to immunohistochemical procedure.
Assuntos
Biomarcadores Tumorais/análise , Neoplasias de Tecido Fibroso/química , Neoplasias de Tecido Fibroso/patologia , Antígeno 12E7 , Actinas/análise , Idoso , Antígenos CD/análise , Antígenos CD34/análise , Moléculas de Adesão Celular/análise , Criança , Desmina/análise , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Índice Mitótico , Necrose , Polimorfismo Genético , Proteínas S100/análise , Vimentina/análiseRESUMO
A 12 year old boy was admitted to the hospital with complaints of stomachache, weight loss, weakness. The first symptoms appeared 6 months ago after intake of the mixture of vinegar, soda and gasoline. The endoscopy showed polypoid mass in the angle of the stomach and malignancy was suspected. Partial resection of the stomach was performed and the boy was discharged from the hospital if satisfactory condition. Microscopic investigation detected spread of fibroblast-like cells containing lengthened nuclei with distinct nucleoli in some of them. There was prominent inflammatory reaction with the presence of neutrophils, macrophages, lymphocytes and many plasma cells. Immunohistochemical analysis showed positive reactions with smooth muscle actin and vimentin. The mass was considered to be an inflammatory pseudotumor. The fact that the lesion developed after the action of the aggressive fluid on the stomach wall permits to consider this event as a possible etiologic factor.
Assuntos
Granuloma de Células Plasmáticas/patologia , Gastropatias/patologia , Criança , Granuloma de Células Plasmáticas/etiologia , Humanos , Masculino , Gastropatias/etiologiaRESUMO
The article touches upon problems of the improvement of transfusiological maintenance of surgical departments with new tendencies in the donor movement taken into account. Specific methods to gain this aim are proposed.
Assuntos
Transfusão de Sangue/normas , Centro Cirúrgico Hospitalar/organização & administração , Transfusão de Componentes Sanguíneos/normas , Transfusão de Componentes Sanguíneos/estatística & dados numéricos , Doadores de Sangue/estatística & dados numéricos , Transfusão de Sangue/estatística & dados numéricos , Humanos , Federação Russa , Inquéritos e QuestionáriosAssuntos
Imunoterapia Adotiva/métodos , Plasma/imunologia , Plasmaferese , Infecções por Pseudomonas/terapia , Adulto , Anticorpos Antibacterianos/sangue , Doadores de Sangue , Transfusão de Sangue , Terapia Combinada , Humanos , Imunização/métodos , Plasmaferese/métodos , Pseudomonas aeruginosa/imunologiaAssuntos
Hipotermia Induzida , Hipotermia/tratamento farmacológico , Procedimentos Cirúrgicos Operatórios , Hormônios do Timo/uso terapêutico , Cicatrização/efeitos dos fármacos , Animais , Homeostase/efeitos dos fármacos , Humanos , Hipotermia/fisiopatologia , Masculino , Camundongos , Coelhos , RatosAssuntos
Teratoma/terapia , Neoplasias Testiculares/terapia , Adulto , Terapia Combinada , Seguimentos , Humanos , Metástase Linfática , Masculino , Teratoma/patologia , Teratoma/radioterapia , Teratoma/cirurgia , Neoplasias Testiculares/patologia , Neoplasias Testiculares/radioterapia , Neoplasias Testiculares/cirurgia , Fatores de TempoAssuntos
Pinos Ortopédicos/efeitos adversos , Osso e Ossos/lesões , Corpos Estranhos/complicações , Migração de Corpo Estranho/complicações , Fixação Intramedular de Fraturas/efeitos adversos , Adulto , Ossos do Carpo/lesões , Fixação Intramedular de Fraturas/instrumentação , Fraturas Ósseas/cirurgia , Humanos , Fraturas do Úmero/cirurgia , Masculino , ReoperaçãoRESUMO
The article generalizes the experience of 11 anastomoses between the bile ducts and the duodenal stump in patients previously operated for ulcer or cancer. These operations were performed in obstruction of the hepatocholedochus resulting from an accidental lesion of bile ducts during resection of the stomach or less frequently by choledocholithiasis, sclerosis of the pancreas head.