1.
Chem Commun (Camb)
; 53(31): 4394-4397, 2017 Apr 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28379228
RESUMO
Dihydroceramide desaturase 1 (Des1) catalyzes the last step of ceramide synthesis de novo, thus regulating the physiologically relevant balance between dihydrosphingolipids and sphingolipids. Here we report on the configurational preference of Des1 towards isomeric Δ6-unsaturated dihydroceramide analogs and the discovery of a potent Des1 inhibitor.