Clinical outcomes and healthcare use associated with optimal ESRD starts.

OBJECTIVES: To assess the association between optimal end-stage renal disease (ESRD) starts and clinical and utilization outcomes in an integrated healthcare delivery system. STUDY DESIGN: Retrospective observational cohort study in 6 regions of an integrated healthcare delivery system, 2011-2013. METHODS: Propensity score techniques were used to match 1826 patients who experienced an optimal start of renal replacement therapy (initial therapy of hemodialysis via an arteriovenous fistula or graft, peritoneal dialysis, or pre-emptive transplant) to 1826 patients who experienced a nonoptimal start (hemodialysis via a central venous catheter). Outcomes included 12-month rates of sepsis, mortality, and utilization (inpatient stays, total inpatient days, emergency department visits, and outpatient visits to primary care and specialty care). RESULTS: Optimal starts were associated with a 65% reduction in sepsis (odds ratio, 0.35; 95% CI, 0.29-0.42) and a 56% reduction in 12-month mortality (hazard ratio, 0.44; 95% CI, 0.36-0.53). Optimal starts were also associated with lower utilization, except for nephrology visits. Large utilization differences were observed for total inpatient days (9.4 for optimal starts vs 27.5 for nonoptimal starts; relative rate [RR], 0.45; 95% CI, 0.38-0.52) and outpatient visits for specialty care other than nephrology or vascular surgery (12.5 vs 18.3, respectively; RR, 0.62; 95% CI, 0.53-0.74). CONCLUSIONS: Compared with patients with nonoptimal starts, patients with optimal ESRD starts have lower morbidity and mortality and less use of inpatient and outpatient care. Late-stage chronic kidney disease and ESRD care in an integrated system may be associated with greater benefits than those previously reported in the literature.

Surgeon volume in thyroid surgery: Surgical efficiency, outcomes, and utilization.

OBJECTIVES/HYPOTHESIS: To test our hypothesis that high-surgeon volume is associated with improved surgical efficiency and 30-day outcomes, and lower hospital utilization. STUDY DESIGN: Retrospective observational cohort, 2008-2013. METHODS: A total of 3,135 patients with hemithyroidectomy or total thyroidectomy performed by a high-volume surgeon, propensity score-matched to 3,135 patients with the same procedure performed by a low-volume surgeon. All-cause 30-day complication, mortality, readmission, and emergency department visit rates, proportion of outpatient procedures, cut-to-close time, and length of stay were assessed. RESULTS: Hemithyroidectomies: Compared to low-volume surgeons, high-volume surgeons had fewer readmitted patients (2.7% vs. 7.0%, P < .05), more outpatient procedures (46% vs. 29%, P < .05), and shorter lengths of stay (mean [standard deviation] 16.6 [22.1] vs. 21.7 [27.5] hours, P < .05) and surgical (cut-to-close) times (1.7 [0.7] vs. 2.0 [1.1] hours, P < .05). Total thyroidectomies: High-volume surgeons had lower rates of all surgery-related complications (5.7% vs. 7.5%, P < .05), hypocalcemia (4.9% vs. 7.0%, P < .05), surgical site infections (0.3% vs. 1.0%, P < .05), more outpatient procedures (13% vs. 3%, P < .05), shorter lengths of stay (29.9 [32.8] vs. 39.8 [36.2] hours, P < .05), and cut-to-close times (2.4 [1.1] vs. 3.0 [1.7] hours, P < .05). CONCLUSION: High-volume surgeons improve patient safety and have the potential to contribute to organizational efficiency that may be underutilized in some settings. LEVEL OF EVIDENCE: 4. Laryngoscope, 126:2630-2639, 2016.

Risk of Complications after Thyroidectomy and Parathyroidectomy: A Case Series with Planned Chart Review.

OBJECTIVE: To develop a predictive model for the risk of complications after thyroid and parathyroid surgery. STUDY DESIGN: Case series with planned chart review of patients undergoing surgery, 2007-2013. SETTING: Kaiser Permanente Northern California and Kaiser Permanente Southern California. SUBJECTS AND METHODS: Patients (N = 16,458) undergoing thyroid and parathyroid procedures were randomly assigned to model development and validation groups. We used univariate analysis to assess relationships between each of 28 predictor variables and 30-day complication rates. We subsequently entered all variables into a recursive partitioning decision tree analysis, with P < .05 as the basis for branching. RESULTS: Among patients undergoing thyroidectomies, the most important predictor variable was thyroid cancer. For patients with thyroid cancer, additional risk predictors included coronary artery disease and central neck dissection. For patients without thyroid cancer, additional predictors included coronary artery disease, dyspnea, complete thyroidectomy, and lobe size. Among patients undergoing parathyroidectomies, the most important predictor variable was coronary artery disease, followed by cerebrovascular disease and chronic kidney disease. The model performed similarly in the validation groups. CONCLUSION: For patients undergoing thyroid surgery, 7 of 28 predictor variables accounted for statistically significant differences in the risk of 30-day complications; for patients undergoing parathyroid surgery, 3 variables accounted for significant differences in risk. This study forms the foundation of a parsimonious model to predict the risk of complications among patients undergoing thyroid and parathyroid surgery.

Safety of Outpatient Thyroid and Parathyroid Surgery: A Propensity Score-Matched Study.

OBJECTIVE: To test our hypothesis that general and thyroid surgery-specific complications, mortality, and postdischarge utilization for patients undergoing outpatient and inpatient thyroid and parathyroid surgery would not differ when outpatient status was defined as discharge within 8 hours of surgery completion. STUDY DESIGN: Retrospective observational cohort, 2008 to 2013. SETTING: Kaiser Permanente Northern California and Kaiser Permanente Southern California. SUBJECTS AND METHODS: We used a robust set of variables and propensity score methods to match 2362 patients undergoing hemithyroidectomy, total thyroidectomy, or parathyroidectomy surgery as outpatients to 2362 patients undergoing the same procedures as inpatients. Outcomes assessed were 30-day rates of complications, emergency department visits, all-cause hospital readmissions, and mortality. RESULTS: After matching, no statistically significant differences between inpatients and outpatients were found for complication rates or postdischarge utilization. After matching, there was no statistically significant difference between inpatients and outpatients in hematoma rates, which were 0.55% in both groups. In the matched-pair groups, 2 deaths occurred among inpatients (0.09%) and none occurred among outpatients (0.00%), a difference that was not statistically significant. CONCLUSION: Discharge within 8 hours after completion of thyroid and parathyroid surgery is as safe as inpatient surgery.