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1.
Med Biol Eng Comput ; 2024 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-39012415

RESUMO

The fight against cancer, a relentless global health crisis, emphasizes the urgency for efficient and automated early detection methods. To address this critical need, this review assesses recent advances in non-invasive cancer prediction techniques, comparing conventional machine learning (CML) and deep neural networks (DNNs). Focusing on these seven major cancers, we analyze 310 publications spanning the years 2018 to 2024, focusing on detection accuracy as the key metric to identify the most effective predictive models, highlighting critical gaps in current methodologies, and suggesting directions for future research. We further delved into factors like datasets, features, and modalities to gain a comprehensive understanding of each approach's performance. Separate review tables for each cancer type and approach facilitated comparisons between top performers (accuracy exceeding 99%) and low performers (65.83 to 85.8%). Our exploration of public databases and commonly used classifiers revealed that optimal combinations of features, datasets, and models can achieve up to 100% accuracy for both CML and DNN. However, significant variations in accuracy (up to 35%) were observed, particularly when optimization was lacking. Notably, colorectal cancer exhibited the lowest accuracy (DNN 69%, CML 65.83%). A five-point comparative analysis (best/worst models, performance gap, average accuracy, and research trends) revealed that while DNN research is gaining momentum, CML approaches remain competitive, even outperforming DNN in some cases. This study presents an in-depth comparative analysis of CML and DNN techniques for cancer detection. This knowledge can inform future research directions and contribute to the development of increasingly accurate and reliable cancer detection tools.

2.
J Cancer Res Clin Oncol ; 150(4): 220, 2024 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-38684578

RESUMO

PURPOSE: The purpose of this study is to develop accurate and automated detection and segmentation methods for brain tumors, given their significant fatality rates, with aggressive malignant tumors like Glioblastoma Multiforme (GBM) having a five-year survival rate as low as 5 to 10%. This underscores the urgent need to improve diagnosis and treatment outcomes through innovative approaches in medical imaging and deep learning techniques. METHODS: In this work, we propose a novel approach utilizing the two-headed UNetEfficientNets model for simultaneous segmentation and classification of brain tumors from Magnetic Resonance Imaging (MRI) images. The model combines the strengths of EfficientNets and a modified two-headed Unet model. We utilized a publicly available dataset consisting of 3064 brain MR images classified into three tumor classes: Meningioma, Glioma, and Pituitary. To enhance the training process, we performed 12 types of data augmentation on the training dataset. We evaluated the methodology using six deep learning models, ranging from UNetEfficientNet-B0 to UNetEfficientNet-B5, optimizing the segmentation and classification heads using binary cross entropy (BCE) loss with Dice and BCE with focal loss, respectively. Post-processing techniques such as connected component labeling (CCL) and ensemble models were applied to improve segmentation outcomes. RESULTS: The proposed UNetEfficientNet-B4 model achieved outstanding results, with an accuracy of 99.4% after postprocessing. Additionally, it obtained high scores for DICE (94.03%), precision (98.67%), and recall (99.00%) after post-processing. The ensemble technique further improved segmentation performance, with a global DICE score of 95.70% and Jaccard index of 91.20%. CONCLUSION: Our study demonstrates the high efficiency and accuracy of the proposed UNetEfficientNet-B4 model in the automatic and parallel detection and segmentation of brain tumors from MRI images. This approach holds promise for improving diagnosis and treatment planning for patients with brain tumors, potentially leading to better outcomes and prognosis.


Assuntos
Neoplasias Encefálicas , Aprendizado Profundo , Imageamento por Ressonância Magnética , Humanos , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/classificação , Neoplasias Encefálicas/patologia , Imageamento por Ressonância Magnética/métodos , Processamento de Imagem Assistida por Computador/métodos , Glioblastoma/diagnóstico por imagem , Glioblastoma/classificação , Glioblastoma/patologia , Glioma/diagnóstico por imagem , Glioma/classificação , Glioma/patologia
3.
J Cancer Res Clin Oncol ; 149(15): 14365-14408, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37540254

RESUMO

PURPOSE: There are millions of people who lose their life due to several types of fatal diseases. Cancer is one of the most fatal diseases which may be due to obesity, alcohol consumption, infections, ultraviolet radiation, smoking, and unhealthy lifestyles. Cancer is abnormal and uncontrolled tissue growth inside the body which may be spread to other body parts other than where it has originated. Hence it is very much required to diagnose the cancer at an early stage to provide correct and timely treatment. Also, manual diagnosis and diagnostic error may cause of the death of many patients hence much research are going on for the automatic and accurate detection of cancer at early stage. METHODS: In this paper, we have done the comparative analysis of the diagnosis and recent advancement for the detection of various cancer types using traditional machine learning (ML) and deep learning (DL) models. In this study, we have included four types of cancers, brain, lung, skin, and breast and their detection using ML and DL techniques. In extensive review we have included a total of 130 pieces of literature among which 56 are of ML-based and 74 are from DL-based cancer detection techniques. Only the peer reviewed research papers published in the recent 5-year span (2018-2023) have been included for the analysis based on the parameters, year of publication, feature utilized, best model, dataset/images utilized, and best accuracy. We have reviewed ML and DL-based techniques for cancer detection separately and included accuracy as the performance evaluation metrics to maintain the homogeneity while verifying the classifier efficiency. RESULTS: Among all the reviewed literatures, DL techniques achieved the highest accuracy of 100%, while ML techniques achieved 99.89%. The lowest accuracy achieved using DL and ML approaches were 70% and 75.48%, respectively. The difference in accuracy between the highest and lowest performing models is about 28.8% for skin cancer detection. In addition, the key findings, and challenges for each type of cancer detection using ML and DL techniques have been presented. The comparative analysis between the best performing and worst performing models, along with overall key findings and challenges, has been provided for future research purposes. Although the analysis is based on accuracy as the performance metric and various parameters, the results demonstrate a significant scope for improvement in classification efficiency. CONCLUSION: The paper concludes that both ML and DL techniques hold promise in the early detection of various cancer types. However, the study identifies specific challenges that need to be addressed for the widespread implementation of these techniques in clinical settings. The presented results offer valuable guidance for future research in cancer detection, emphasizing the need for continued advancements in ML and DL-based approaches to improve diagnostic accuracy and ultimately save more lives.

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