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1.
Eur J Clin Nutr ; 61(3): 334-41, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16988651

RESUMO

OBJECTIVE: Arabinoxylan (AX) consumption is associated with metabolic improvement during diabetes and with modulation of ghrelin, an orexigenic gut hormone. The effect of AX consumption on ghrelin secretion in disturbed metabolic states is unknown. Therefore, we investigated the postprandial responses to AX consumption of serum glucose, insulin and triglycerides and plasma total and acylated ghrelin in subjects with impaired glucose tolerance (IGT). DESIGN: Randomized, single-blind, controlled, crossover intervention trial. SUBJECTS: Seven female and four male adults with IGT, aged 55.5 years, and body mass index (BMI) 30.1 kg/m(2). INTERVENTION: Subjects received either placebo or 15 g AX supplement for 6 weeks with a 6-week washout period in-between. MAIN OUTCOME MEASUREMENTS: Postprandial responses of serum glucose, insulin and triglycerides, and plasma total and acylated ghrelin after a liquid meal challenge test (LMCT) measured at the beginning and at the end of the dietary intervention at -20, -5, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 min. RESULTS: After LMCT, AX consumption resulted in lower postprandial responses in serum glucose, insulin and triglycerides (P<0.05). Compared to placebo, total plasma ghrelin was also reduced by 42+/-8 pg/ml (P<0.001) after AX consumption with no difference in plasma acylated ghrelin. CONCLUSION: AX consumption improved postprandial metabolic responses after an LMCT in subjects with IGT and reduced total ghrelin response. However, acylated ghrelin responses were unchanged, suggesting that the acylated ghrelin-mediated orexigenic regulation is not improved as only total plasma ghrelin decreased.


Assuntos
Glicemia/metabolismo , Fibras na Dieta/administração & dosagem , Intolerância à Glucose/tratamento farmacológico , Insulina/sangue , Hormônios Peptídicos/sangue , Xilanos/administração & dosagem , Idoso , Área Sob a Curva , Estudos Cross-Over , Suplementos Nutricionais , Feminino , Grelina , Intolerância à Glucose/sangue , Intolerância à Glucose/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Prandial , Método Simples-Cego , Solubilidade , Fatores de Tempo , Triglicerídeos/sangue
2.
Horm Metab Res ; 38(11): 761-6, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17111305

RESUMO

The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.


Assuntos
Adiponectina/sangue , Fibras na Dieta/uso terapêutico , Intolerância à Glucose/tratamento farmacológico , Intolerância à Glucose/metabolismo , Glucose/metabolismo , Xilanos/uso terapêutico , Adulto , Idoso , Glicemia/metabolismo , Composição Corporal/fisiologia , Índice de Massa Corporal , Colesterol/sangue , Feminino , Hemoglobinas Glicadas/metabolismo , Humanos , Insulina/sangue , Leptina/sangue , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Resistina/sangue , Método Simples-Cego , Triglicerídeos/sangue
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