Unsteady hybrid nanofluid (Cu-UO2/blood) with chemical reaction and non-linear thermal radiation through convective boundaries: An application to bio-medicine.

This study is focused on modeling and simulations of hybrid nanofluid flow. Uranium dioxide UO2 nanoparticles are hybrid with copper Cu, copper oxide CuO and aluminum oxide Al2O3 while considering blood as a base fluid. The blood flow is initially modeled considering magnetic effect, non-linear thermal radiation and chemical reactions along with convective boundaries. Then for finding solution of the obtained highly nonlinear coupled system we propose a methodology in which q-homotopy analysis method is hybrid with Galerkin and least square Optimizers. Residual errors are also computed in this study to confirm the validity of results. Analysis reveals that rate of heat transfer in arteries increases up to 13.52 Percent with an increase in volume fraction of Cu while keeping volume fraction of UO2 fixed to 1% in a base fluid (blood). This observation is in excellent agreement with experimental result. Furthermore, comparative graphical study of Cu,CuO and Al2O3 for increasing volume fraction is also performed keeping UO2 volume fraction fixed. Investigation indicates that Cu has the highest rate of heat transfer in blood when compared with CuO and Al2O3. It is also observed that thermal radiation increases the heat transfer rate in the current study. Furthermore, chemical reaction decreases rate of mass transfer in hybrid blood nanoflow. This study will help medical practitioners to minimize the adverse effects of UO2 by introducing hybrid nano particles in blood based fluids.

Analysis of blood flow of unsteady Carreau-Yasuda nanofluid with viscous dissipation and chemical reaction under variable magnetic field.

Blood flow analysis through arterial walls depicts unsteady non-Newtonian fluid flow behavior. Arterial walls are impacted by various chemical reactions and magnetohydrodynamic effects during treatment of malign and tumors, cancers, drug targeting and endoscopy. In this regard, current manuscript focuses on modeling and analysis of unsteady non-Newtonian Carreau-Yasuda fluid with chemical reaction, Brownian motion and thermophoresis under variable magnetic field. The main objective is to simulate the effect of different fluid parameters, especially variable magnetic field, chemical reaction and viscous dissipation on the blood flow to help medical practitioners in predicting the changes in blood to make diagnosis and treatment more efficient. Suitable similarity transformations are used for the conversion of partial differential equations into a coupled system of ordinary differential equations. Homotopy analysis method is used to solve the system and convergent results are drawn. Effect of different dimensionless parameters on the velocity, temperature and concentration profiles of blood flow are analyzed in shear thinning and thickening cases graphically. Analysis reveals that chemical reaction increases blood concentration which enhance the drug transportation. It is also observed that magnetic field elevates the blood flow in shear thinning and thickening scenarios. Furthermore, Brownian motion and thermophoresis increases temperature profile.

Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma.

Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The signaling cascades are stimulated via genetic modifications in upstream signaling molecules, which affect apoptotic, proliferative, and differentiation pathways. Dysregulation of these signaling cascades causes cancer-initiating cell proliferation, cancer development, and drug resistance. Numerous efforts in the treatment of NSCLC have been undertaken in the past few decades, enhancing our understanding of the mechanisms of cancer development and moving forward to develop effective therapeutic approaches. Modifications of transcription factors and connected pathways are utilized to develop new treatment options for NSCLC. Developing designed inhibitors targeting specific cellular signaling pathways in tumor progression has been recommended for the therapeutic management of NSCLC. This comprehensive review provided deeper mechanistic insights into the molecular mechanism of action of various signaling molecules and their targeting in the clinical management of NSCLC.

Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders.

BACKGROUND: Ficus palmata (Fig), are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including inflammation, tumor, epilepsy, jaundice, influenza and bacillary dysentery. The present study aimed to evaluate the antidiarrheal, antisecretary, antispasmodic, antiulcer and anti motility properties of Ficus palmata. METHODS: In-vivo, in-vitro and in-silico techniques were used to investigate various gastrointestinal effects of Ficus palmata. Antidiarrheal, antisecretary, antispasmodic, antiulcer, anti motility and molecular docking were performed using castor oil induced diarrhea and fluid accumulation, isolated tissue preparations, ethanol-HCl induced ulcer assay, charcoal meal transit time and Auto Doc Vina. RESULTS: Ficus palmata crude extract (Fp.Cr) exhibited protection against castor oil-induced diarrhea in mice and dose-dependently inhibited intestinal fluid secretions. Fp.Cr caused relaxation of spontaneous and K+ (80 Mm)-induced contractions in isolated rabbit jejunum preparations. It showed protective effect against gastric ulcers induced by ethanol-hydrochloric acid in rats. Fp.Cr reduced distance travelled by charcoal meal in the gastrointestinal transit model in mice. The plant constituents: psoralenoside and bergapten showed high binding affinities (E-value ≥ - 6.5 Kcal/mol) against histaminergic H1, calmodulin and voltage gated L-type calcium channels, while showed moderate affinities (E-value ≥7 Kcal/mol) against dopaminergic D2, adrenergic α1, muscranic M3, mu-opioid, whereas revealed lower affinities (E-value ≥9.5 Kcal/mol) vs. muscranic M1, histaminergic H2 and H+/K+ ATPase pump. Germanicol acetate and psoralene exhibited weak affinities against aforementioned targets. CONCLUSION: This study reveals that Ficus palmata possesses anti-diarrheal, anti-secretory, anti-spasmodic, anti-motility and anti-ulcer activities. The various constituents reveal different binding affinities against target proteins, which mediate the gastrointestinal functions.