Lesions in the oral mucosa associated with the use of checkpoint inhibitors: A bibliometric and critical review.

AIMS: Immune-related adverse events (irAEs) linked to the use of immune checkpoint inhibitors (ICIs) have become increasingly frequent. To perform a bibliometric and critical review of the general panorama of publications on oral mucosal lesions (OML) associated with ICIs. METHODS AND RESULTS: Systematized searches were performed in four databases. The included studies were organized and bibliometric and clinical data were extracted and analyzed using VantagePoint and Microsoft Excel. Most of the 35 included studies were reports or case series (n = 33/94.2%). The American authors stood out (n = 17/48.5%), with the majority presenting only one publication. Independent groups carried out most of the publications (n = 31/88.5%). Over the years, publications have increased for users of nivolumab and pembrolizumab. In 21 studies (60%), OML were more common in men, between the 6th and 9th decades of life and who had lung carcinoma (n = 13/37.1%). Pembrolizumab (n = 17/48.5%) was the most used ICI. The patients were affected by one or more OML, including: ulcers (n = 28/80%) and erythema (n = 11/31.4%). Systemic corticosteroids (n = 24/68.5%) and the discontinuation of ICI use (n = 18/51.4%) were the main approaches used. CONCLUSION: OML related to the use of ICIs have become increasingly common. More accurate data need to be published.

YouTube™ como uma fonte de informações sobre odontologia do sono / YouTube™ as a source of information about dental sleep medicine

Objetivo: Avaliar a qualidade e a confiabilidade do conteúdo de vídeos sobre Odontologia do Sono no YouTube™. Métodos: Foi realizada uma busca no YouTube™, utilizando o termo "Odontologia do Sono", na qual selecionou-se os 100 primeiros vídeos para análise realizada por dois pesquisadores. Foram incluídos vídeos sobre o tema, na língua portuguesa brasileira, com no máximo 24 minutos. Foram extraídos: título, data, duração, visualização, curtida, fonte, público-alvo, objetivo e assunto. A qualidade foi avaliada através da Escala de Qualidade Global (EQG), e a confiabilidade, através da adaptação de um índice previamente publicado, ambos pontuando até 5 pontos, onde mais pontos significavam maior qualidade e confiabilidade. Foram realizados os testes de Mann-Whitney U, Kruskal-Wallis e a correlação de Spearman (p < 0,05). Resultados: 58 vídeos foram incluídos, cuja mediana da duração foi 2,4 ± 7,6 minutos. A maioria dos vídeos era produzida por cirurgiões-dentistas (CD) (75,9%; n = 44), sobre apneia (96,6%; n = 56), com o objetivo educacional/informativo (65,5%; n = 38) e direcionado para leigos (58,6%; n = 34). A maioria apresentou mediana baixa de 2,0 ± 1,0 na EQG (41,4%; n = 24), e na escala de confiabilidade, a mediana de 3,0 ± 1,0 (60,3%; n = 35). Houve correlação moderada da EQG (p = 0,62; p < 0,01) e da confiabilidade (ρ = 0,41; p < 0,01) com a duração do vídeo, e também entre EQG e confiabilidade (ρ = 0,66; p < 0,01). Vídeos educacionais/informativos, produzidos por CD, e direcionados a leigos, apresentaram uma maior EQG e confiabilidade (p < 0,01). Vídeos que incluíam bruxismo tinham maior EQG (p = 0,01). Programas de televisão e vídeos que não eram comerciais apresentaram maior confiabilidade (p < 0,05). Conclusão:A maioria dos vídeos possuía qualidade baixa e confiabilidade moderada. Vídeos educacionais/informativos, feitos por CD, direcionados a leigos, que incluíam bruxismo, programas de televisão e que não eram comerciais, apresentaram maior qualidade e confiabilidade.

Aim: To assess the quality and reliability of video content on Dental Sleep Medicine on YouTube™. Methods: A search was performed on YouTube™ using the term "Dental Sleep Medicine". The first 100 videos were selected for analysis by two researchers. Videos on the subject were included, in Brazilian Portuguese with a maximum of 24 minutes. The following data were extracted: title, date, duration, views, likes, source, target audience, objective and subject. Quality was assessed using the Global Quality Scale (GQS), and reliability using a previously published index adapted, both ranging from 1 to 5 points, where more points meant greater quality and reliability. Spearman correlation, Mann-Whitney U, and Kruskal-Wallis test (p < 0.05) were performed. Results: 58 videos were included, with a median duration of 2.4 ± 7.6 minutes. Most of the videos were produced by dentists (75.9%; n = 44), about apnea (96.6%; n = 56), with an educational/informational objective (65.5%; n =38), and aimed at laypeople (58.6%; n = 34). Most had a low median of 2.0 ± 1.0 on the GQS (41.4%; n = 24), and on the reliability scale, the median was 3.0 ± 1.0 (60.3%; n = 35). There was a moderate correlation between both GQS (ρ = 0.62; p < 0.01) and reliability (ρ = 0.41; p < 0.01) with video duration, and also between GQS and reliability (ρ = 0 .66; p < 0.01). Educational/informational videos, produced by dentists, and aimed at laypeople showed higher GQS and reliability (p < 0.01). Videos that included bruxism had higher GQS (p = 0.01). Television programs and non-commercial videos were more reliable (p < 0.05). Conclusion: Most videos had low quality and moderate reliability. Educational/informational videos, made by dentists, aimed at laypeople, that included bruxism, television programs, and that were not commercials, presented higher quality and reliability.