RESUMO
We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
Assuntos
Animais , Masculino , Ratos , Diabetes Mellitus Experimental/patologia , Mastócitos/patologia , Timo/patologia , Aloxano , Contagem de Células , Ratos WistarAssuntos
Matriz Extracelular/patologia , Rejeição de Enxerto/imunologia , Transplante de Coração/imunologia , Neutrófilos/fisiologia , Animais , Fibronectinas/análise , Rejeição de Enxerto/patologia , Transplante de Coração/patologia , Macrófagos/patologia , Macrófagos/fisiologia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Neutrófilos/patologia , Transplante HomólogoRESUMO
Histoincompatible skin grafts in rabbits treated with cyclosporine can permanently engraft but show a transient mononuclear cellular infiltrate. This transient cyclosporine-resistant infiltrate consists of cells which are sensitive to steroids, radiation and cryopreservation. They have the same ACM-1 phenotype and the same characteristics as cyclosporine-sensitive cells.