RESUMO
BACKGROUND: Topical tazarotene has been shown to offer efficacy in ameliorating multiple effects of photodamage. OBJECTIVES: To evaluate the histological effects of tazarotene cream on photodamaged skin. METHODS: In this multicentre, double-blind, randomized, vehicle-controlled study, 50 patients with photodamaged facial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1% cream or vehicle cream to their face, once daily for 24 weeks. RESULTS: Blinded assessments showed that tazarotene was less likely than vehicle to be associated with an increase in keratinocytic and melanocytic atypia, and more likely than vehicle to be associated with a reduction in atypia. Between-group comparisons in distribution of change from baseline categories of severity were in favour of tazarotene (P = 0.055 for keratinocytic atypia, P = 0.034 for melanocytic atypia, and P < 0.001 for the number of granular cell layers). Compared with vehicle, tazarotene was associated with an increase in epidermal polarity (P = 0.008) and epidermal thickness (P = 0.012), and a tendency for stratum corneum compaction. Tazarotene was also associated with widened intercellular spaces (reported as epidermal oedema) relative to vehicle (P < 0.001). CONCLUSIONS: Treatment of photodamaged skin with tazarotene is associated with an amelioration of keratinocytic and melanocytic atypia, an improvement in epidermal polarity, and an increase in epidermal thickness.
Assuntos
Dermatoses Faciais/tratamento farmacológico , Hiperpigmentação/tratamento farmacológico , Ceratolíticos/uso terapêutico , Ácidos Nicotínicos/uso terapêutico , Envelhecimento da Pele/efeitos dos fármacos , Adulto , Idoso , Método Duplo-Cego , Dermatoses Faciais/patologia , Feminino , Humanos , Hiperpigmentação/patologia , Queratinócitos/patologia , Ceratolíticos/efeitos adversos , Masculino , Melanócitos/patologia , Pessoa de Meia-Idade , Ácidos Nicotínicos/efeitos adversos , Veículos Farmacêuticos/efeitos adversos , Veículos Farmacêuticos/uso terapêutico , Índice de Gravidade de Doença , Envelhecimento da Pele/patologia , Resultado do TratamentoRESUMO
Granuloma fissuratum is a reactive process of the skin usually caused by chronic trauma from ill-fitting eyeglass frames. Its clinical resemblance to malignant tumors makes it important to recognize this benign condition. This case report discuses the diagnosis and management of granuloma fissuratum.
Assuntos
Granuloma/diagnóstico , Dermatopatias/diagnóstico , Neoplasias Cutâneas/diagnóstico , Diagnóstico Diferencial , Óculos , Granuloma/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Dermatopatias/etiologiaRESUMO
A case of tinea of the pinna, mistaken for chondritis, is presented. Chondritis should be added to the list of diseases that tinea infection may mimic.