Retinal vein occlusion. Audit of a specialized care program.

BACKGROUND AND OBJECTIVES: Retinal vein occlusion (RVO) is the second most frequent cause of retinal vascular disease and is related to classic cardiovascular risk factors. A specific program was designed to detect and treat risk factors in patients with RVO. The aim of this study is to audit the results of this program. PATIENTS AND METHODS: The program consisted of a multidisciplinary clinical evaluation by the Ophthalmology and Internal Medicine Departments. All patients with RVO were screened, at minimum, for hypertension, diabetes, dyslipidemia, smoking, overweight, and antiphospholipid syndrome. New risk factors or poor control of known risk factors were expected to be found in at least one-third of the patients. Among them, therapeutic measures were expected to be taken in at least two-thirds. A dissociated automated search of the data of all patients who entered the program between April 2021 and April 2022 was performed. RESULTS: Fifty-six patients were included for analysis. Of these, 39 (69.6%) had at least one new or poorly controlled risk factor and 43 (76.8%) had their treatment modified in some way. Antiphospholipid syndrome was detected in five (8.9%). Only one patient had low-risk hereditary thrombophilia. After an exhaustive examination, no risk factors were found in 11 patients. CONCLUSION: This specific program has been effective in detecting new or poorly controlled risk factors and improving their treatment.

Global microRNA profiling identified miR-10b-5p as a regulator of neurofibromatosis 1 (NF1)-glioma migration.

AIMS: Neurofibromatosis 1 (NF1) is an autosomal-dominant cancer predisposition syndrome caused by loss of function alterations involving the NF1 locus on chromosome 17. The most common brain tumours encountered in affected patients are low-grade gliomas (pilocytic astrocytomas), although high-grade gliomas are also observed at increased frequency. While bi-allelic NF1 loss characterizes these tumours, previous studies have suggested noncoding RNA molecules (microRNA, miR) may have important roles in dictating glioma biology. METHODS: To explore the contributions of miRs in NF1-associated gliomas, we analysed five high-grade gliomas (NF1-HGG) and five PAs (NF1-PA) using global microRNA profiling with NanoString-based microarrays followed by functional experiments with glioma cell lines. RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR-1247-5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). As miR-10b-5p was the microRNA overexpressed the most in NF1-high-grade glioma compared to NF1-low-grade glioma (5.76 fold), we examined its levels in glioma cell lines. miR-10b-5p levels were highest in adult glioma cell lines and lowest in paediatric low-grade glioma lines (P = 0.02). miR-10b-5p knockdown resulted in decreased invasion in NF1-deficient LN229 high-grade glioma line, whereas its overexpression in the NF1-PA derived line (JHH-NF1-PA1) led to increased invasion. There was no change in cell growth (viability and proliferation). CONCLUSIONS: These proof-of-concept experiments support a role for microRNA regulation in NF1-glioma biology.

[Exposed dislocation of the first and second cuneiform bones and fracture in situ of the third cuneiform bone of the foot: Clinical case and literature review]. / Luxación expuesta de la primera y segunda cuña y fractura in situ de la tercera cuña del pie: Caso clínico y revisión de la literatura.

BACKGROUNDS: The isolated fracture/dislocation of the cuneiform bones is a not very frequent event and only a few cases have been reported in the literature. This type of event is presented as a variation of the Lisfranc injuries. The present report shows a rare clinical case of a patient with dislocation of the first and second cuneiform bones and fracture in situ of the third cuneiform bone of the left foot. CASE REPORT: A 49-year-old female patient presented severe traumatism of the dorsum of the foot with bony and soft tissue exposure as a result of a car accident. The patient underwent surgery in the emergency department consisting of surgical cleaning, debridement, reduction of dislocation of the first and second cuneiform bones and percutaneous fixation with 2.0 mm Kirschner wires. RESULTS: After the surgery, the patient was found to be in good general condition, oriented without pain, stable, conscious, without traces of active bleeding from the wound and with the presence of Kirschner wires in an appropriate position. DISCUSSION: An exhaustive inspection of the injury is recommended through the analysis of X-ray images, CT scans or magnetic resonance imaging, especially in unexposed lesions in order to apply the appropriate treatment and be able to achieve a prompt recovery of the patient.

ANTECEDENTES: La fractura y la luxación aislada de los huesos cuneiformes son un evento no muy frecuente y sólo pocos casos han sido reportados en la literatura. Este tipo de eventos se presenta como una variación de las lesiones de Lisfranc. El presente reporte muestra un caso clínico poco frecuente de un paciente con luxación de la primera y segunda cuña y fractura in situ de la tercera cuña del pie izquierdo. CASO CLÍNICO: Mujer de 49 años de edad, que presentó traumatismo severo del dorso del pie con exposición de tejido óseo y blando como consecuencia de atropellamiento. La paciente fue sometida a cirugía en el Servicio de Urgencias, donde se realizó aseo quirúrgico, desbridamiento, reducción de la luxación de la primera y segunda cuña y fijación percutánea con clavillos Kirschner de 2.0 mm. RESULTADOS: Posterior a la cirugía, la paciente se reportó con buen estado en general, orientada, sin facie de dolor, estable, consciente, sin huellas de sangrado activo por la herida y con presencia de clavillos Kirschner en adecuada posición. DISCUSIÓN: Se recomienda una inspección exhaustiva de la lesión a través del análisis de las imágenes de rayos X, tomografía computarizada o imágenes de resonancia magnética, especialmente en lesiones no expuestas, pues con ello se puede aplicar el tratamiento adecuado y lograr una pronta recuperación del paciente.

Desarrollo de una herramienta computacional para el análisis de conductancia galvánica de la piel, ECG y frecuencia respiratoria por arritmia sinusal respiratoria (SCRATER) / Development of a computational tool for the analysis of galvanic skin conductance, EKG and respiratory rate due to respiratory sinus arrhythmia (SCRATER)

Resumen: La existencia de una correlación entre la frecuencia cardíaca (FC), la frecuencia respiratoria (FR) y las respuestas electrodérmicas de la piel (Skin Conductance Response, SCR) ha sido reportada en la literatura, así como también el uso de estos parámetros como medida del nivel de activación del sistema nervioso autónomo. Objetivo: Este trabajo presenta una herramienta (SCRATER) para el análisis conjunto de SCR, FC y FR, las dos últimas, calculadas a partir del análisis del registro de electrocardiograma (ECG). Metodología: En esta investigación, se realizó una descripción detallada de cada algoritmo desarrollado, asi como una una descripción de la interfaz para utilizarlos. En la validación de los algoritmos empleados, se analizaron 192 registros de ECG y 231 registros de actividad electrodérmica (Electro-Dermal Activity, EDA) de 40 participantes masculinos sanos, de los cuales se calculó el número de complejos QRS y FC en cada registro de ECG y el número de SCRs de cada registro de EDA. Resultados: Los datos obtenidos fueron comparados con otras herramientas que analizan SCR y FC pero de manera independiente, obteniendo resultados equiparables mediante coeficientes de correlación. Limitaciones: El ruido y los artefactos presentes en los registros no permiten una correcta estimación de los parámetros y afectan los resultados de todas las herramientas empleadas en el desarrollo de este trabajo. Valor: SCRATER ofrece tres ventajas principales sobre las otras herramientas: 1) libre acceso, 2) código abierto y no utiliza formatos codificados o exclusivos. Conclusión: Este trabajo proporciona una herramienta computacional gratuita que permite analizar simultáneamente SCRs, FC y FR.

Abstract: The existence of a correlation between heart rate (HR), respiratory rate (RR) and skin conductance response (SCR) has been reported in the literature, as well as the use of these parameters as a measure of the activation level of the autonomous nervous system. Objective: This paper introduces a computational tool (SCRATER) developed with the aim to analyze simultaneous recordings of SCR, and heart and respiratory rates, which were calculated from the electrocardiogram recording (ECG) analysis. Methodology: In this research, a detailed description of each developed algorithm was made, as well as a description of the interface to be used. In the validation of the algorithms used, 192 ECG records and 231 Electro-Dermal Activity (EDA) registers of 40 healthy male participants were analyzed, from which the number of QRS complexes and HR in each ECG record and the number of SCRs of each EDA record are calculated. Results: The data obtained were compared with other tools that analyze SCR and HR separately, obtaining comparable results using correlation coefficients. Limitations: The noise and artifacts present in the records do not allow a correct estimation of the parameters and affect the results of all the tools used in the development of this work. Value: SCRATER offers three main advantages over other tools: 1) free access, 2) open source and 3) does not use coded or exclusive formats. Conclusion: This work provides a free computational tool that allows simultaneous analysis of SCRs, FC and FR.

A prognostic score to identify low-risk outpatients with acute deep vein thrombosis in the upper extremity.

BACKGROUND: No studies have identified which patients with upper-extremity deep vein thrombosis (DVT) are at low risk for adverse events within the first week of therapy. METHODS: We used data from Registro Informatizado de la Enfermedad TromboEmbólica to explore in patients with upper-extremity DVT a prognostic score that correctly identified patients with lower limb DVT at low risk for pulmonary embolism, major bleeding, or death within the first week. RESULTS: As of December 2014, 1135 outpatients with upper-extremity DVT were recruited. Of these, 515 (45%) were treated at home. During the first week, three patients (0.26%) experienced pulmonary embolism, two (0.18%) had major bleeding, and four (0.35%) died. We assigned 1 point to patients with chronic heart failure, creatinine clearance levels 30-60 mL min(-1) , recent bleeding, abnormal platelet count, recent immobility, or cancer without metastases; 2 points to those with metastatic cancer; and 3 points to those with creatinine clearance levels < 30 mL min(-1) . Overall, 759 (67%) patients scored ≤ 1 point and were considered to be at low risk. The rate of the composite outcome within the first week was 0.26% (95% confidence interval [CI] 0.004-0.87) in patients at low risk and 1.86% (95% CI 0.81-3.68) in the remaining patients. C-statistics was 0.73 (95% CI 0.57-0.88). Net reclassification improvement was 22%, and integrated discrimination improvement was 0.0055. CONCLUSIONS: Using six easily available variables, we identified outpatients with upper-extremity DVT at low risk for adverse events within the first week. These data may help to safely treat more patients at home.

Caracterización del consumo de suplementos nutricionales en población físicamente activa de gimnasios del sur de Chile / Characterization of nutritional supplements consumption in physically active population in gyms of southern Chile

El consumo de suplementos nutricionales (SN) se ha investigado generalmente en relación al rendimiento deportivo. Menos información existe en relación a población no deportista pero físicamente activa. Objetivo y metodología: El objetivo fue conocer las características de los consumidores de SN en 412 usuarios (179 mujeres) de gimnasios de cuatro ciudades del sur de Chile. El instrumento utilizado para recolectar datos correspondió a un cuestionario previamente validado (1), estructurado con preguntas cerradas, alternativas y preguntas abiertas en relación al consumo de SN. Para su interpretación se utilizaron estadísticos descriptivos y de comparación (i.e. Chi cuadrado). El nivel de significancia estadística se estableció en p<0,05. Resultados: los resultados revelan que 22% de los usuarios consumen SN. De los hombres consumidores, 37% lo realiza para aumentar masa muscular y 36% para mejorar el rendimiento físico. Entre las mujeres, 32% los consume por motivos relacionados a salud. Los SN más consumidos fueron: proteínas (36%), vitaminas y minerales (11%), creatina (10%), aminoácidos y carbohidratos (8%). En cuanto al perfil del consumidor, está representado por jóvenes de entre 15 a 25 años, dedicados en su mayoría al estudio y al trabajo, con menos de un año de asistencia al gimnasio y una frecuencia de asistencia ≥ 3 sesiones/semana. Conclusión: un relativamente bajo consumo de SN fue observado,en comparación con deportistas, influenciado por la edad,el género y el uso de dieta o alimentación especial. Varones jóvenes (i.e. 15 a 25 años de edad) que trabajan, con una alta frecuencia de asistencia a gimnasios (≥ 3 sesiones/semana) son los principales consumidores de SN...

EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood worldwide and Mexico has reported one of the highest incidence rates. An infectious etiology has been suggested and supported by epidemiological evidences; however, the identity of the involved agent(s) is not known. We considered that early transmitted lymphotropic herpes viruses were good candidates, since transforming mechanisms have been described for them and some are already associated with human cancers. In this study we interrogated the direct role of EBV, HCMV, HHV6, and HHV7 human herpes viruses in childhood ALL. Viral genomes were screened in 70 bone marrow samples from ALL patients through standard and a more sensitive nested PCR. Positive samples were detected only by nested PCR indicating a low level of infection. Our result argues that viral genomes were not present in all leukemic cells, and, hence, infection most likely was not part of the initial genetic lesions leading to ALL. The high statistical power of the study suggested that these agents are not involved in the genesis of ALL in Mexican children. Additional analysis showed that detected infections or coinfections were not associated with prognosis.

Glassy carbon electrodes sequentially modified by cysteamine-capped gold nanoparticles and poly(amidoamine) dendrimers generation 4.5 for detecting uric acid in human serum without ascorbic acid interference.

Glassy carbon electrodes (GCE) were sequentially modified by cysteamine-capped gold nanoparticles (AuNp@cysteamine) and PAMAM dendrimers generation 4.5 bearing 128-COOH peripheral groups (GCE/AuNp@cysteamine/PAMAM), in order to explore their capabilities as electrochemical detectors of uric acid (UA) in human serum samples at pH 2. The results showed that concentrations of UA detected by cyclic voltammetry with GCE/AuNp@cysteamine/PAMAM were comparable (deviation <±10%; limits of detection (LOD) and quantification (LOQ) were 1.7×10(-4) and 5.8×10(-4) mg dL(-1), respectively) to those concentrations obtained using the uricase-based enzymatic-colorimetric method. It was also observed that the presence of dendrimers in the GCE/AuNp@cysteamine/PAMAM system minimizes ascorbic acid (AA) interference during UA oxidation, thus improving the electrocatalytic activity of the gold nanoparticles.

Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia.

BACKGROUND: Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS). METHODS: A case-control study was performed in Mexico City. The cases (n=97) were diagnosed at nine public hospitals, and the controls (n=222) were recruited at institutions for children with DS. Odds ratios (OR) were calculated. RESULTS: Asthma was positively associated with AL development (OR=4.18; 95% confidence interval (CI): 1.47-11.87), whereas skin allergies were negatively associated (OR=0.42; 95% CI: 0.20-0.91). CONCLUSION: Our findings suggest that allergies and AL in children with DS share biological and immune mechanisms. To our knowledge, this is the first study reporting associations between allergies and AL in children with DS.

Rosette forming glioneuronal tumor in association with Noonan syndrome: pathobiological implications.

Noonan syndrome, a distinctive syndrome characterized by dysmorphism, cardiac abnormalities and developmental delay, has been associated with a number of malignancies, however, only a few cases of primary glial or glioneuronal neoplasms have been reported. We report here the case of an 18-year-old with Noonan syndrome who developed a rosette forming glioneuronal tumor of the posterior fossa. The tumor demonstrated strong pERK immunoreactivity, suggesting MAPK/ERK pathway activation. Molecular testing did not reveal BRAF rearrangements (fusion transcripts) by PCR or a BRAFV600E mutation by sequencing. We review the literature regarding the molecular pathogenesis of Noonan syndrome and primary brain tumors, and consider the intriguing link between their common molecular pathways.

Expression of diagnostic neuronal markers and outcome in glioblastoma.

BACKGROUND: High-grade gliomas featuring giant cells, often demonstrate immunoreactivity for neuronal markers, a finding prognostically significant according to some studies. We investigated this event in glioblastomas (GBM). METHODS: Immunoexpression for synaptophysin, neurofilament protein, neuronal nuclear antigen, chromogranin and glial fibrillary acidic protein was analysed in 82 GBM including 11 fibrillary, 8 gemistocytic, 40 giant cell and 23 small cell examples. Survival was compared between tumours exhibiting (GBMpos) or lacking (GBMneg) neuronal markers and also between tumours expressing only one vs. two or more neuronal markers. RESULTS: Forty-five of the 82 tumours (54.8%) including 5 fibrillary, 5 gemistocytic, 30 giant cell and 5 small cell GBMs expressed at least one neuronal marker, synaptophysin being the most frequent (96%). There was no statistically significant difference in survival between GBMpos and GBMneg tumours, all cytologic subtypes combined (P = 0.22). The same was true when cytologic categories were compared. When only GBMpos tumours were analysed, there was a marginally significant difference in outcome between tumours positive for one vs. multiple markers (P = 0.05). This difference was influenced primarily by giant cell GBMs among which the survival time was significantly shorter in the multiple vs. single marker category (median 123 vs. 295 days, P = 0.014). This difference was not observed in the other GBM cell types. Ultrastructurally, rare neurosecretory granules in glial filament-rich cells were identified in one of four tumours studied. CONCLUSIONS: Neuronal marker expression is a frequent feature of GBM. Its prognostic significance is limited to the giant cell GBMs expressing two or more neuronal markers, these being associated with shorter survival.

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.

OBJECTIVE: Independent studies have previously demonstrated that both the HIPK2 and BRAF genes are amplified and rearranged, respectively, in pilocytic astrocytomas (PAs). The purpose of this study was to further investigate the frequency of BRAF and HIPK2 alterations in PAs, the concordance of these events, and their relationship to clinical phenotype. METHODS: We performed extensive characterization by array-based copy number assessment (aCGH), HIPK2 copy number analysis, and BRAF rearrangement and mutation analysis in a set of 79 PAs, including 9 tumors from patients with neurofibromatosis type 1 (NF1). RESULTS: We identified 1 of 3 previously identified BRAF rearrangements in 42/70 sporadic PAs. An additional 2 tumors with no rearrangement also exhibited BRAF mutation, including a novel 3-base insertion. As predicted from the genomic organization at this locus, 22/36 tumors with BRAF rearrangement also exhibited corresponding HIPK2 amplification. However, 14/36 tumors with BRAF rearrangement had no detectable HIPK2 gene amplification and 6/20 tumors demonstrated HIPK2 amplification without apparent BRAF rearrangement or mutation. Only 12/70 PAs lacked detectable BRAF or HIPK2 alterations. Importantly, none of the 9 PA tumors from NF1 patients exhibited BRAF rearrangement or mutation. CONCLUSIONS: BRAF rearrangement represents the most common genetic alteration in sporadic, but not neurofibromatosis type 1-associated, pilocytic astrocytomas (PAs). These findings implicate BRAF in the pathogenesis of these common low-grade astrocytomas in children, and suggest that PAs arise either from NF1 inactivation or BRAF gain of function.

Alginate- and gellan-based edible films for probiotic coatings on fresh-cut fruits.

Alginate- (2% w/v) or gellan-based (0.5%) edible films, containing glycerol (0.6% to 2.0%), N-acetylcysteine (1%), and/or ascorbic acid (1%) and citric acid (1%), were formulated and used to coat fresh-cut apple and papaya cylinders. Water vapor permeability (WVP) was significantly higher (P < 0.05) in alginate films (0.30 to 0.31 x 10(-9) g m/Pa s m2) than in the gellan ones (0.26 to 0.27 x 10(-9) g m/Pa s m2). Addition of 0.025% (w/v) sunflower oil decreased WVP of gellan films (0.20 to 0.22 x 10(-9) g m/Pa s m2). Water solubility of gellan and alginate films at 25 degrees C (0.47 to 0.59 and 0.74 to 0.79, respectively) and their swelling ratios (2.3 to 2.6 and 1.6 to 2.0, respectively) indicate their potential for coating high moisture fresh-cut fruits. Fresh-cut apple and papaya cylinders were successfully coated with 2% (w/v) alginate or gellan film-forming solutions containing viable bifidobacteria. WVP in alginate (6.31 and 5.52 x 10(-9) g m/Pa s m2) or gellan (3.65 and 4.89 x 10(-9) g m/Pa s m2) probiotic coatings of papaya and apple, respectively, were higher than in the corresponding cast films. The gellan coatings and films exhibited better water vapor properties in comparison with the alginate coatings. Values > 10(6) CFU/g B. lactis Bb-12 were maintained for 10 d during refrigerated storage of fresh-cut fruits, demonstrating the feasibility of alginate- and gellan-based edible coatings to carry and support viable probiotics on fresh-cut fruit.

Infiltrative chordoid meningioma of the pineal region: a study of 2 cases.

OBJECTIVE: Meningiomas involving the pineal region are rare. Herein we describe two cases of chordoid meningioma with histologic evidence of pineal gland infiltration. MATERIALS AND METHODS: Clinical histories were abstracted from chart review and consultation letters. HE-stained slides were reviewed in both cases. Selected immunohistochemical stains were performed. RESULTS: the patients included a 44-year-old male and a 37-year-old female who presented with symptoms of intracranial tumor referable to the pineal region. On magnetic resonance imaging (MRI), both lesions demonstrated heterogeneous contrast enhancement. Histologically, the tumors were characterized by strands and cords ofmeningothelial cells arranged in a mucinous stroma. In addition, obvious meningothelial cytology as well as focal osseous metaplasia (Case 1), and transitional histology (Case 2) were also noted. Tumor cells demonstrated EMA and focal S100 protein immunoreactivity, but lacked cytokeratin AE1/AE3 and glial fibrillary acidic protein (GFAP) staining. Synaptophysin and neurofilament protein highlighted the overrun pineal gland parenchyma. MIB1-proliferative index was 8.4 and 20.1%, respectively. CONCLUSIONS: Chordoid meningioma, although rare, may occur in the pineal region. The differential diagnosis of this meningioma subtype in this location is discussed.

Outcomes of vitreoretinal surgery for retinal detachment after LASIK for myopia.

PURPOSE: To report and compare outcomes of vitreoretinal surgery for repair of retinal detachment in myopic patients with and without previous laser-assisted in situ keratomileusis (LASIK). METHODS: This is a descriptive retrospective observational study with a control group for comparison that consisted of the analysis of clinical and surgical charts of patients who underwent vitreoretinal procedures for retinal detachment at the Fundación Oftalmologica Nacional between January 1995 and December 2002. The authors identified those myopic patients who had previous history of LASIK and an age- and myopia-matched control group without refractive surgery. RESULTS: The sample contains 24 myopic eyes of 22 patients with previous LASIK and 23 myopic eyes without previous LASIK in the control group, matched by age and myopia. Mean refractive error was -9.4 D before LASIK for the cases group and -11.2 for the control group. Poor preoperative best-corrected visual acuity was present in 71% of cases and 61% of controls (p=0.489). Macula off retinal detachment was found in 17 eyes in both groups. Five eyes required at least two procedures, achieving 91% (20 eyes) reattachments at the end of follow-up in each group. Final best-corrected visual acuity was better than 20/100 in 15 eyes (62.5%) in the LASIK group and 17 eyes (74 %) in the control group (p=0.659). CONCLUSIONS: Retinal detachment in patients with previous myopic LASIK has similar characteristics as in myopic patients without refractive surgery. Current vitreoretinal surgery is of good prognosis as the retina was successfully reattached in most cases in both groups.

Vitreoretinal surgery for macular hole after laser assisted in situ keratomileusis for the correction of myopia.

UNLABELLED: AMS: To describe the characteristics and surgical outcomes of full thickness macular hole surgery after laser assisted in situ keratomileusis (LASIK) for the correction of myopia. METHODS: 13 patients (14 eyes) who developed a macular hole after bilateral LASIK for the correction of myopia participated in the study. RESULTS: Macular hole formed 1-83 months after LASIK (mean 13 months). 11 out of 13 (84.6%) patients were female. Mean age was 45.5 years old (25-65). All eyes were myopic (range -0.50 to -19.75 dioptres (D); mean -8.4 D). Posterior vitreous detachment (PVD) was not present before and was documented after LASIK on 42.8% of eyes. Most macular hole were unilateral, stage 4 macular hole, had no yellow deposits on the retinal pigment epithelium, had no associated epiretinal membrane, were centric, and had subretinal fluid. The mean diameter of the hole was 385.3 microm (range 200--750 microm). A vitrectomy closed the macular hole on all eyes with an improvement on final best corrected visual acuity (VA) on 13 out of 14 (92.8%) patients. CONCLUSIONS: This study shows that vitreoretinal surgery can be successful in restoring vision for most myopic eyes with a macular hole after LASIK.