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1.
Rev Esp Quimioter ; 32(3): 238-245, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30968675

RESUMO

OBJECTIVE: To assess the impact of the first months of application of a Code Sepsis in a high complexity hospital, analyzing patient´s epidemiological and clinical characteristics and prognostic factors. METHODS: A long-term observational study was carried out throughout a consecutive period of seven months (February 2015 - September 2015). The relationship with mortality of risk factors, and analytic values was analyzed using uni- and multivariate analyses. RESULTS: A total of 237 patients were included. The in-hospital mortality was 24% at 30 days and 27% at 60 days. The mortality of patients admitted to Critical Care Units was 30%. Significant differences were found between the patients who died and those who survived in mean levels of creatinine (2.30 vs 1.46 mg/dL, p <0.05), lactic acid (6.10 vs 2.62 mmol/L, p <0.05) and procalcitonin (23.27 vs 12.73 mg/dL, p<0.05). A statistically significant linear trend was found between SOFA scale rating and mortality (p<0.05). In the multivariate analysis additional independent risk factors associated with death were identified: age > 65 years (OR 5.33, p <0.05), lactic acid > 3 mmol/L (OR 5,85, p <0,05), creatinine > 1,2 mgr /dL (OR 4,54, p <0,05) and shock (OR 6,57, P <0,05). CONCLUSIONS: The epidemiological, clinical and mortality characteristics of the patients in our series are similar to the best published in the literature. The study has identified several markers that could be useful at a local level to estimate risk of death in septic patients. Studies like this one are necessary to make improvements in the Code Sepsis programs.


Assuntos
Protocolos Clínicos , Sepse/terapia , APACHE , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Biomarcadores , Creatinina/sangue , Feminino , Mortalidade Hospitalar/tendências , Hospitais Universitários , Humanos , Ácido Láctico/sangue , Masculino , Pessoa de Meia-Idade , Pró-Calcitonina/sangue , Prognóstico , Fatores de Risco , Sepse/mortalidade , Resultado do Tratamento
4.
Med Intensiva ; 36(3): 235, 2012 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-21683478
5.
Gastroenterol Hepatol ; 26(10): 639-42, 2003 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-14670238

RESUMO

Acquired immune deficiency syndrome increases the risk of developing non-Hodgkin's B-cell lymphoma (NHL) (relative risk over 100). NHL tend to be high-grade and to affect the central nervous system and digestive tract. Biliary tract compression is usually due to external compression from enlarged lymph nodes, but is not usually the first manifestation.We describe 2 cases of bile duct obstruction secondary to NHL in patients diagnosed with HIV infection. Histological diagnosis of the lymphoma can be difficult but is necessary so that these patients do not undergo highly aggressive surgical treatment instead of chemotherapy, which currently produces the best results. Therefore, we emphasize the importance of including lymphomas in the differential diagnosis of bile duct obstruction in patients with HIV infection.


Assuntos
Colestase/etiologia , Infecções por HIV/complicações , HIV-1/patogenicidade , Linfoma de Células B/complicações , Medula Óssea/patologia , Colestase/patologia , Colestase/cirurgia , Drenagem/métodos , Evolução Fatal , Feminino , Infecções por HIV/diagnóstico , Infecções por HIV/terapia , Humanos , Imuno-Histoquímica , Linfoma de Células B/diagnóstico por imagem , Linfoma de Células B/terapia , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
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