RESUMO
The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.
Assuntos
Biópsia Guiada por Imagem , Neoplasias Cutâneas , Humanos , Biópsia por Agulha Fina , Ultrassonografia , Ultrassonografia de Intervenção , Neoplasias Cutâneas/diagnóstico por imagem , Estudos RetrospectivosRESUMO
The generation of cell blocks (CBs) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.
Assuntos
Biópsia Guiada por Imagem , Neoplasias Cutâneas , Humanos , Biópsia por Agulha Fina , Ultrassonografia , Ultrassonografia de Intervenção , Neoplasias Cutâneas/diagnóstico por imagem , Estudos RetrospectivosAssuntos
Hemangioma Capilar , Hemangioma , Adulto , Eritema/etiologia , Hemangioma/diagnóstico , Humanos , LactenteRESUMO
BACKGROUND: We reviewed all cases of multiple primary melanoma diagnosed at our department over a 32-year period (1987-2019) to better characterize this subgroup of patients and develop a tailored protocol to offer them closer follow-up. METHODS: Retrospective, observational, descriptive study of patients diagnosed with multiple primary melanoma at a tertiary care hospital between January 1987 and March 2019. We collected clinical, epidemiologic, and histologic characteristics of primary and subsequent melanomas and performed a descriptive analysis. RESULTS: Thirty-one patients (15 men and 16 women) with a median age of 67years (range, 36-85years) were included. Second primary melanomas were diagnosed after a median of 2years (range, 0-4years). The median number of melanomas per patient was 2 (range, 2-6). Twenty-three of the 31 patients, 25 had 2 primary melanomas (80%), 4 had 3 melanomas (13%), and 2 patients each had 5 and 6 primary melanomas. Subsequent melanomas were less invasive than the initial primary melanomas. Median Breslow thickness was 1mm (range, 0.67-4mm) for the first primary melanoma and 0.5mm (range, 0.32-2.42mm) for subsequent melanomas. CONCLUSIONS: Subsequent melanomas are thinner than primary melanomas. We observed an increase in the number of cases of multiple primary melanoma diagnosed in the last 2years of our study. Our findings highlight the importance of close, long-term follow-up of patients.
Assuntos
Melanoma , Neoplasias Primárias Múltiplas , Neoplasias Cutâneas , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Melanoma/epidemiologia , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/epidemiologia , Estudos Retrospectivos , Neoplasias Cutâneas/epidemiologiaAssuntos
Infecções por Herpesviridae/transmissão , Imunossupressores/efeitos adversos , Transplante de Pulmão/efeitos adversos , Complicações Pós-Operatórias/etiologia , Sarcoma de Kaposi/etiologia , Neoplasias Torácicas/etiologia , Anticorpos Antivirais/sangue , Substituição de Medicamentos , Eritema/etiologia , Everolimo/uso terapêutico , Herpesvirus Humano 8/imunologia , Herpesvirus Humano 8/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Ácido Micofenólico/efeitos adversos , Ácido Micofenólico/uso terapêutico , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/virologia , Sarcoma de Kaposi/diagnóstico , Sarcoma de Kaposi/virologia , Tacrolimo/efeitos adversos , Tacrolimo/uso terapêutico , Neoplasias Torácicas/diagnóstico , Neoplasias Torácicas/virologia , Doadores de Tecidos , Viremia/diagnóstico , Viremia/etiologiaRESUMO
Advances in our understanding of the biology and therapy of vascular anomalies have made this condition a common reason for consulting a dermatologist. In addition, multidisciplinary units have been created to manage patients with complex vascular anomalies. Although most vascular anomalies are diagnosed based on clinical findings, a thorough evaluation often requires additional imaging tests to determine the nature, extension, and prognosis of these lesions. Because it is fast and noninvasive, ultrasound is usually the first imaging test ordered. In the present review, we provide a state-of-the-art synthesis of key concepts in the ultrasound examination of vascular anomalies so that they are more accessible to clinicians and medical imaging specialists involved in the management of these lesions.
Assuntos
Dermatopatias Vasculares/diagnóstico por imagem , Ultrassonografia , Malformações Vasculares/diagnóstico por imagem , Hemangioma/diagnóstico por imagem , Humanos , Neoplasias Cutâneas/diagnóstico por imagemRESUMO
Recent years have witnessed an increase in the use of ultrasound imaging of the skin in the field of dermatology, as the technique reveals details of vessels and other structures that cannot be detected on physical examination. Extradigital glomus tumors are rarely seen in clinical practice and can pose a diagnostic challenge for dermatologists. We report on 4 patients with a clinical suspicion of extradigital glomus tumor and on 1 patient with a clinical suspicion of subungual glomus tumor. All 5 patients underwent ultrasound examination in B mode and color and pulsed-wave Doppler prior to surgical excision of the tumor and histologic examination, which confirmed the diagnosis in each case. Ultrasound imaging of the skin, combined with clinical findings, provided a simple, noninvasive way of making a prompt diagnosis and identifying the exact location of the lesion for surgical removal.
Assuntos
Dedos , Tumor Glômico/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , UltrassonografiaRESUMO
A forty-two-year-old male recipient of a cadaver renal transplant showed multiple nodulocystic lesions on his back and lateral aspects of his neck four months after beginning immunosuppressive therapy with cyclosporine A and prednisone. Results of histopathologic studies revealed that they were epidermoid infundibular cysts. We note the relationship between this clinical appearance and cyclosporine A, as well as this agent's cutaneous side effects.