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1.
Qual Life Res ; 25(3): 625-36, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26790428

RESUMO

PURPOSE: To derive a health state classification system (HSCS) from the cancer-specific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a multi-attribute utility instrument. METHODS: The conceptual model for the HSCS was based on the established domain structure of the QLQ-C30. Several criteria were considered to select a subset of dimensions and items for the HSCS. Expert opinion and patient input informed a priori selection of key dimensions. Psychometric criteria were assessed via secondary analysis of a pooled dataset comprising HRQOL and clinical data from 2616 patients from eight countries and a range of primary cancer sites, disease stages, and treatments. We used confirmatory factor analysis (CFA) to assess the conceptual model's robustness and generalisability. We assessed item floor effects (>75 % observations at lowest score), disordered item response thresholds, coverage of the latent variable and differential item function using Rasch analysis. We calculated effect sizes for known group comparisons based on disease stage and responsiveness to change. Seventy-nine cancer patients assessed the relative importance of items within dimensions. RESULTS: CFA supported the conceptual model and its generalisability across primary cancer sites. After considering all criteria, 12 items were selected representing 10 dimensions: physical functioning (mobility), role functioning, social functioning, emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems. CONCLUSIONS: The HSCS created from QLQ-C30 items is known as the EORTC Quality of Life Utility Measure-Core 10 dimensions (QLU-C10D). The next phase of the QLU-C10D's development involves valuation studies, currently planned or being conducted across the globe.


Assuntos
Nível de Saúde , Aptidão Física , Qualidade de Vida/psicologia , Inquéritos e Questionários , Adulto , Idoso , Análise Fatorial , Fadiga/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Dor/complicações , Psicometria/métodos , Reprodutibilidade dos Testes
2.
Qual Life Res ; 25(3): 637-49, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26342928

RESUMO

PURPOSE: To assess the feasibility of using a discrete choice experiment (DCE) to value health states within the QLU-C10D, a utility instrument derived from the QLQ-C30, and to assess clarity, difficulty, and respondent preference between two presentation formats. METHODS: We ran a DCE valuation task in an online panel (N = 430). Respondents answered 16 choice pairs; in half of these, differences between dimensions were highlighted, and in the remainder, common dimensions were described in text and differing attributes were tabulated. To simplify the cognitive task, only four of the QLU-C10D's ten dimensions differed per choice set. We assessed difficulty and clarity of the valuation task with Likert-type scales, and respondents were asked which format they preferred. We analysed the DCE data by format with a conditional logit model and used Chi-squared tests to compare other responses by format. Semi-structured telephone interviews (N = 8) explored respondents' cognitive approaches to the valuation task. RESULTS: Four hundred and forty-nine individuals were recruited, 430 completed at least one choice set, and 422/449 (94 %) completed all 16 choice sets. Interviews revealed that respondents found ten domains difficult but manageable, many adopting simplifying heuristics. Results for clarity and difficulty were identical between formats, but the "highlight" format was preferred by 68 % of respondents. Conditional logit parameter estimates were monotonic within domains, suggesting respondents were able to complete the DCE sensibly, yielding valid results. CONCLUSION: A DCE valuation task in which only four of the QLU-C10D's ten dimensions differed in any choice set is feasible for deriving utility weights for the QLU-C10D.


Assuntos
Nível de Saúde , Neoplasias/psicologia , Psicometria/métodos , Qualidade de Vida/psicologia , Inquéritos e Questionários , Comportamento de Escolha , Feminino , Humanos , Modelos Logísticos , Masculino , Telefone
3.
Int J STD AIDS ; 24(8): 613-7, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23970570

RESUMO

Increasing screening frequency in men who have sex with men (MSM) engaging in high-risk behaviours can reduce prevalence of sexually transmitted infections (STIs). This evaluation investigated the impact of applying stricter screening guidelines for MSM on service workload and earlier STI diagnoses. A validated risk assessment tool (RAT) was distributed to MSM attending a level 3 sexual health service over three months. Australian screening guidelines were applied to the data to identify MSM requiring more frequent screening and data projected to the larger MSM population. The RAT identified a 2-5-fold increase in the number of STI and HIV screenings required based on six- and three-monthly screening intervals, respectively, in the MSM cohort. When screening intervals are reduced from three-monthly to six-monthly there is a potential loss of 66.7% of earlier HIV diagnoses. The use of RATs will increase workload in sexual health services, but potentially diagnose a large proportion of disease earlier.


Assuntos
Infecções por HIV/diagnóstico , Homossexualidade Masculina/estatística & dados numéricos , Programas de Rastreamento/estatística & dados numéricos , Guias de Prática Clínica como Assunto , Infecções Sexualmente Transmissíveis/diagnóstico , Diagnóstico Precoce , Fidelidade a Diretrizes , Infecções por HIV/epidemiologia , Pesquisa sobre Serviços de Saúde , Homossexualidade Masculina/psicologia , Humanos , Masculino , Programas de Rastreamento/métodos , Prevalência , Reprodutibilidade dos Testes , Medição de Risco , Assunção de Riscos , Parceiros Sexuais , Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/prevenção & controle , Inquéritos e Questionários , Reino Unido/epidemiologia , Carga de Trabalho
4.
Int J STD AIDS ; 22(2): 115-6, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21427437

RESUMO

Laryngeal histoplasmosis is very rare among patients with HIV and very few cases have so far been documented. We report a case of laryngeal histoplasmosis in a patient with no prior AIDS defining diagnosis, which mimicked epithelial neoplasia, and was treated successfully with oral fluconazole.


Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Histoplasmose/diagnóstico , Rouquidão/diagnóstico , Doenças da Laringe/diagnóstico , Administração Oral , Antifúngicos/administração & dosagem , Fluconazol/administração & dosagem , Histoplasmose/complicações , Humanos , Doenças da Laringe/patologia , Masculino , Pessoa de Meia-Idade
6.
Sex Transm Infect ; 85(7): 514-9, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19700413

RESUMO

OBJECTIVES: To compare the efficacy and safety of combination therapy with cryotherapy and podophyllotoxin 0.15% cream versus cryotherapy alone in the treatment of anogenital warts. METHODS: A randomised, double-blind, multicentre controlled trial. Patients received podophyllotoxin cream or placebo twice daily for 3 days/week for up to 4 weeks, with weekly cryotherapy continued to week 12 if required. Further treatment from week 12 to 24 was discretionary. Patients were stratified by sex and history of warts. HIV positivity, warts treated in the past 4 months, or warts with a combined area of less than 10 mm(2) were exclusion criteria. Primary endpoints were clearance at weeks 4 and 12. RESULTS: 70 patients per group were randomly assigned and started treatment; 101 first-episode warts, 91 male. No treatment-related serious adverse events were reported. Follow-up at week 12 was 85%. By intention-to-treat analysis, clearances at 4 and 12 weeks were higher in the combination group (60.0% and 60.0%, respectively) than with cryotherapy alone (45.7%, 45.7%) although not statistically significant (RR 1.31, 95% CI 0.95 to 1.81). By week 24 there was no difference between the groups (68.6% and 64.3%, respectively; RR 1.07, CI 0.84 to 1.35). At week 4, wart clearance was higher in men (p = 0.001) and those with a past history of warts (p = 0.009), but these differences were not detected at week 12. There was some evidence for a higher relapse rate in the group receiving cryotherapy alone. CONCLUSIONS: Initial combination therapy with podophyllotoxin/cryotherapy was well tolerated and may have resulted in earlier clearance in some patients, compared with cryotherapy alone; however, overall differences in clearance rates were not statistically significant.


Assuntos
Antivirais/administração & dosagem , Doenças do Ânus/tratamento farmacológico , Condiloma Acuminado/tratamento farmacológico , Crioterapia/métodos , Podofilotoxina/administração & dosagem , Doenças Urológicas/tratamento farmacológico , Adolescente , Adulto , Terapia Combinada , Método Duplo-Cego , Métodos Epidemiológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pomadas , Recidiva , Resultado do Tratamento , Adulto Jovem
7.
Int J STD AIDS ; 17(7): 491-2, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16820084

RESUMO

Patients with penile lesions, such as virally induced papillomata, frequently present to genitourinary medicine clinics and general practitioners. Their diagnosis is usually based on clinical observation and biopsy is not generally undertaken. Penile lesions may rarely have a more sinister aetiology and represent metastatic spread from solid tumours arising at distant sites. Penile metastases arise most frequently from genitourinary cancers (prostate, bladder and kidney), but may also arise from tumours of the large bowel; other primary sites are extremely uncommon. We report the case of a patient presenting with penile metastases from rectal carcinoma arising during third-line chemotherapy for metastatic disease.


Assuntos
Adenocarcinoma/secundário , Neoplasias Penianas/secundário , Pênis/patologia , Neoplasias Retais/patologia , Verrugas/diagnóstico , Adenocarcinoma/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Pênis/diagnóstico , Doenças do Pênis/patologia , Neoplasias Penianas/diagnóstico
8.
Microbiology (Reading) ; 151(Pt 7): 2251-2261, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16000715

RESUMO

Mucoid strains of Pseudomonas aeruginosa that overproduce the exopolysaccharide alginate are a frequent cause of chronic respiratory infections in cystic fibrosis (CF) patients. The overproduction of alginate by these strains is often caused by mutations within mucA of the algU mucABCD gene cluster. This gene cluster encodes an extreme stress response system composed of the ECF alternative sigma factor AlgU, the anti-sigma factor MucA located in the inner membrane and the negative regulator MucB located in the periplasm. Most of the mutations in mucA found in mucoid strains cause a truncation of the C-terminal, periplasmic domain of MucA. The most significant effect of these mutations appears to be to reduce the levels of MucA. PA3257 (prc) was identified as a regulator of alginate production in P. aeruginosa through the isolation and study of mutations that partially suppressed the mucoid phenotype of a mucA22 strain. The suppressor of mucoidy (som) mutants isolated produced very little alginate when grown on LB medium, but were still mucoid when grown on Pseudomonas isolation agar. These som mutations and another previously isolated suppressor mutation were complemented by cosmids or plasmids carrying PA3257. PA3257 is predicted to encode a periplasmic protease similar to Prc or Tsp of Escherichia coli. Sequencing of prc from three strains with som suppressor mutations confirmed that each had a mutation within the prc coding region. The authors propose that Prc acts to degrade mutant forms of MucA. Additional evidence in support of this hypothesis is: (1) transcription from the AlgU-regulated algD reporter was reduced in som mutants; (2) inactivation of prc affected alginate production in mucoid strains with other mucA mutations found in CF isolates; (3) inactivation or overexpression of prc did not affect alginate production in strains with wild-type MucA.


Assuntos
Proteínas de Bactérias/metabolismo , Endopeptidases/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Alginatos/metabolismo , Proteínas de Bactérias/genética , Membrana Celular/metabolismo , Regulação Bacteriana da Expressão Gênica , Mutação , Pseudomonas aeruginosa/fisiologia
9.
Mol Microbiol ; 36(2): 314-27, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10792719

RESUMO

The conversion to mucoid phenotype in Pseudomonas aeruginosa during chronic infections in cystic fibrosis (CF) is due to mutations in the algU mucABCD gene cluster. This cluster encodes an extreme stress response system conserved in Gram-negative bacteria. The system includes an ECF sigma factor, AlgU (sigmaE), an inner membrane protein, MucA, which inhibits AlgU activity, and MucB, a periplasmic protein that negatively controls AlgU. In this work, we investigated whether and how these factor interact to transduce signals between different cellular compartments. The mutation mucADeltaG440, which renders a large fraction of P. aeruginosa CF isolates mucoid, did not abrogate AlgU-MucA interactions, although it eliminated MucA-MucB interactions in the yeast two-hybrid system. The mucADeltaG440 truncation of the periplasmic C-terminal tail of MucA destabilized the molecule resulting in low or undetectable steady-state levels in P. aeruginosa. Somewhat reduced levels of MucA were also seen in cells with inactivated mucB or with the mucACF53 allele carrying the missense P184S mutation, which mildly affected interactions with MucB. The events downstream from MucA destabilization were also investigated. AlgU was found to associate with inner membranes in mucA+ cells. In mutants destabilizing MucA, a limited redistribution of AlgU from the membrane to the cytosol was observed. The redistribution was spontaneous in mucADeltaG440 cells, while in mucB and mucACF53 mutants it required additional signals. Despite a large reduction in MucA levels in mucADeltaG440 cells, only a small fraction of AlgU was redistributed to the cytosol and a significant portion of this sigma factor remained membrane bound and behaved as a peripheral inner membrane protein. The fraction of AlgU that depended on MucA for association with the membrane also brought RNA polymerase into this compartment. These results are consistent with a model in which MucB-MucA-AlgU-RNA polymerase interactions at the membrane allow transduction of potentially lethal stress signals with both rapid reaction times of the preassembled complexes and efficient resupply at the membrane from the prebound components.


Assuntos
Proteínas de Bactérias/metabolismo , Membrana Celular/metabolismo , Fibrose Cística/microbiologia , Citosol/metabolismo , Pseudomonas aeruginosa/patogenicidade , Fator sigma/metabolismo , Alelos , Proteínas de Bactérias/genética , RNA Polimerases Dirigidas por DNA/metabolismo , Resposta ao Choque Térmico , Mutação , Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa/genética , Pseudomonas aeruginosa/isolamento & purificação , Pseudomonas aeruginosa/fisiologia , Fator sigma/genética , Técnicas do Sistema de Duplo-Híbrido
10.
Dermatol Clin ; 16(4): 835-8, 1998 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9891690

RESUMO

Much progress has been made over the past 10 years with regard to development of a vaccine active against HPV. Successful protection has been achieved in animal models using species-specific papillomaviruses; however, HPV diversity may delay the development of successful HPV vaccines, especially those designed as therapeutic vaccines for the treatment of HPV-induced carcinoma and high-grade dysplasia of the cervix. Difficulties arise with regard to assessment of efficacy of potential vaccines. The impetus for long-term studies on vaccine efficacy will initially stem from in vitro evidence of responsiveness to the vaccine. The time when a vaccine will have an impact on the prevalence of high-grade dysplasia and invasive cancer is still some way off.


Assuntos
Papillomaviridae/imunologia , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus , Infecções Tumorais por Vírus/prevenção & controle , Vacinas Virais , Animais , Carcinoma de Células Escamosas/prevenção & controle , Carcinoma de Células Escamosas/terapia , Carcinoma de Células Escamosas/virologia , Condiloma Acuminado/prevenção & controle , Condiloma Acuminado/terapia , Condiloma Acuminado/virologia , Modelos Animais de Doenças , Feminino , Genoma Viral , Humanos , Esquemas de Imunização , Masculino , Papillomaviridae/genética , Infecções por Papillomavirus/terapia , Lesões Pré-Cancerosas/prevenção & controle , Lesões Pré-Cancerosas/terapia , Lesões Pré-Cancerosas/virologia , Infecções Tumorais por Vírus/terapia , Displasia do Colo do Útero/prevenção & controle , Displasia do Colo do Útero/terapia , Displasia do Colo do Útero/virologia , Vacinação , Proteínas Virais/genética
11.
Microbiology (Reading) ; 143 ( Pt 11): 3473-3480, 1997 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9387225

RESUMO

Alginate production in Pseudomonas aeruginosa and the associated mucoid phenotype of isolates from cystic fibrosis patients are under the control of the algU mucABCD cluster. This group of genes encodes AlgU, the P. aeruginosa equivalent of the extreme heat shock sigma factor sigma E in Gram-negative bacteria, the AlgU-cognate anti-sigma factor MucA, the periplasmic protein MucB and a serine protease homologue, MucD. While mucA, mucB or mucD act as negative regulators of AlgU, the function of mucC is not known. In this study the role of mucC in P. aeruginosa physiology and alginate production has been addressed. Insertional inactivation of mucC in the wild-type P. aeruginosa strain PAO1 did not cause any overt effects on alginate synthesis. However, it affected growth of P. aeruginosa under conditions of combined elevated temperature and increased ionic strength or osmolarity. Inactivation of mucC in mucA or mucB mutant backgrounds resulted in a mucoid phenotype when the cells were grown under combined stress conditions of elevated temperature and osmolarity. Each of the stress factors tested separately did not cause comparable effects. The combined stress factors were not sufficient to cause phenotypically appreciable enhancement of alginate production in mucA or mucB mutants unless mucC was also inactivated. These findings support a negative regulatory role of mucC in alginate production by P. aeruginosa, indicate additive effects of muc genes in the regulation of mucoidy in this organism and suggest that multiple stress signals and recognition systems participate in the regulation of algU-dependent functions.


Assuntos
Alginatos/metabolismo , Proteínas de Bactérias/fisiologia , Regulação Bacteriana da Expressão Gênica/fisiologia , Pseudomonas aeruginosa/metabolismo , Fator sigma , Proteínas de Bactérias/genética , Fibrose Cística/microbiologia , Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos , Ácido Glucurônico , Ácidos Hexurônicos , Temperatura Alta , Humanos , Mutagênese Insercional , Mutação , Concentração Osmolar , Fenótipo , Pseudomonas aeruginosa/genética , Pseudomonas aeruginosa/crescimento & desenvolvimento , Espécies Reativas de Oxigênio , Cloreto de Sódio/farmacologia
12.
Int J STD AIDS ; 6(4): 251-6, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-7548287

RESUMO

Rates of screening for sexually transmissible infections in patients using different services provided by a genitourinary medicine clinic for testing for HIV antibodies are presented. Those patients whose primary reason for attending the clinic was HIV antibody testing and used the same day result (SDR) service were significantly less likely to be screened for other infections than those using the normal waiting time (NWT) service, (P < 0.00001). This was true for both males and females. Of those patients screened for other infections in the SDR and NWT groups 29% and 35% respectively were found to have a sexually transmitted infection. It would appear that an SDR service offers little benefit for the majority of patients as only a few patients would not have had an HIV antibody test had the SDR not been available.


Assuntos
Infecções por HIV/diagnóstico , Programas de Rastreamento/métodos , Infecções Sexualmente Transmissíveis/diagnóstico , Sorodiagnóstico da AIDS/métodos , Adulto , Feminino , Infecções por HIV/complicações , Humanos , Masculino , Prontuários Médicos , Ambulatório Hospitalar , Estudos Retrospectivos , Infecções Sexualmente Transmissíveis/complicações , Inquéritos e Questionários , Listas de Espera
13.
Clin Immunol Immunopathol ; 69(3): 333-40, 1993 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8242905

RESUMO

Monoclonal murine anti-idiotypic antibodies generated against purified human anti-thyroglobulin (TG) antibodies from a patient with Hashimoto's thyroiditis recognized two major clusters of idiotopes (1C2 and 1B1) on human anti-thyroglobulin antibodies which were framework and paratope-related. A survey of affinity-purified autoantibodies from Hashimoto's patients indicated that the 1C2 and 1B1 idiotopes are expressed on the disease-associated anti-TG antibodies from several patients. 1C2 and 1B1 idiotopes are also detected on affinity-purified anti-TG antibodies isolated from serum of healthy donors and with therapeutic preparations of immunoglobulins obtained from plasma pools of healthy individuals. The observation that both framework and paratope-related idiotopes are shared by natural and patients' autoantibodies suggests that the anti-TG autoantibodies found in sera of patients with Hashimoto's disease represent an abnormal expansion of normal autoreactive B cell clones rather than the emergency of an antigen-driven, disease-specific B cell response.


Assuntos
Anticorpos Anti-Idiotípicos/imunologia , Anticorpos Monoclonais/imunologia , Autoanticorpos/imunologia , Camundongos Endogâmicos BALB C/imunologia , Tireoglobulina/imunologia , Tireoidite/imunologia , Animais , Autoimunidade/fisiologia , Humanos , Imunoglobulina G/imunologia , Idiótipos de Imunoglobulinas/análise , Imunoglobulinas Intravenosas/imunologia , Camundongos , Tireoidite Autoimune/imunologia
14.
Genitourin Med ; 67(6): 460-3, 1991 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-1774050

RESUMO

OBJECTIVE: To determine whether women who have a history of genital warts or whose sexual partners have such a history were more likely to have borderline or dyskaryotic cervical smears than other women. DESIGN: Prospective study conducted over a five month period. SETTING: A genitourinary medicine clinic in Cambridge, UK. PATIENTS: One hundred and eighty five women who attended the clinic during the study period, on whom cervical cytology was performed. Ninety-seven had a history of genital warts and twenty had partners with genital warts. METHODS: Cervical cytology taken by standard methods. Demographic data and sexual history obtained by questionnaire. Colposcopy was performed on patients with a history of warts or wart contact. OUTCOME MEASURED: Relative incidence of cytological abnormalities in the various groups of patients. RESULTS: "Borderline" nuclear change was the most frequent abnormality reported in the wart contact group (six cases) whereas mild dyskaryosis was the most frequent abnormal finding in those women with a history of warts (21 cases). CONCLUSIONS: Women with warts or contact with genital warts were more likely to have borderline or dyskaryotic cervical smears than women without such a history. Recommendations for follow-up of these patients are made.


Assuntos
Condiloma Acuminado/complicações , Neoplasias do Colo do Útero/etiologia , Adulto , Colo do Útero/patologia , Feminino , Humanos , Estudos Prospectivos , Neoplasias do Colo do Útero/patologia , Esfregaço Vaginal
15.
Genitourin Med ; 67(1): 41-3, 1991 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-1916776

RESUMO

A questionnaire was sent to all genitourinary medicine (GUM) clinics in the United Kingdom. Physicians were asked whether women attending the clinics were routinely screened for Chlamydia trachomatis, what treatment was given and whether and how a test of cure (TOC) was carried out after treatment; 94.5% of clinics responded. Screening for chlamydia was not carried out routinely in 4.8% of clinics. Treatments and their costs varied widely between clinics; six antibiotics were prescribed in 35 different ways. Less than half the clinics used regimens compatible with the advice of the World Health Organisation (WHO) and the Centers for Disease Control (CDC). Antibiotics in larger doses and/or for longer durations than those known to be effective were prescribed in 85% of clinics. Unnecessary routine TOC were carried out by 86% of clinics in 29 different ways. Sixteen percent of clinics carried out TOC immediately after completion of therapy, which is inadvisable on technical grounds. There is a need to standardise and improve the treatment and follow-up of chlamydial infection in women attending GUM clinics.


Assuntos
Antibacterianos/uso terapêutico , Infecções por Chlamydia/tratamento farmacológico , Chlamydia trachomatis , Vaginose Bacteriana/diagnóstico , Antibacterianos/administração & dosagem , Infecções por Chlamydia/diagnóstico , Esquema de Medicação , Feminino , Imunofluorescência , Seguimentos , Humanos , Técnicas Imunoenzimáticas , Fatores de Tempo , Reino Unido
16.
Genitourin Med ; 66(6): 444-6, 1990 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-2265843

RESUMO

Tests of cure (TOC) were performed on specimens from 106 women following treatment for chlamydial infection of the cervix. 91 women attended for the first TOC with enzyme immunoassay (EIA) within one week of finishing antibiotics. Three were EIA positive, 88 were EIA negative. These three women were subsequently EIA and culture negative although they received no further antibiotics. Ninety women returned for the second TOC with EIA and culture between seven and 27 days after completing treatment. All the results were negative. Routine TOC is unnecessary following appropriate antichlamydial therapy. If TOC is indicated antigen-detection methods should not be used immediately after finishing antibiotics as misleading positive results may be obtained. EIA or culture at one week or later after treatment is reliable.


Assuntos
Infecções por Chlamydia/diagnóstico , Chlamydia trachomatis , Doenças do Colo do Útero/diagnóstico , Infecções por Chlamydia/tratamento farmacológico , Doxiciclina/uso terapêutico , Feminino , Humanos , Técnicas Imunoenzimáticas , Oxitetraciclina/uso terapêutico , Doenças do Colo do Útero/tratamento farmacológico , Doenças do Colo do Útero/microbiologia
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