Prolymphocytic leukemia: a very satisfactory response to treatment with recombinant interferon alpha.

We report the case of a patient with prolymphocytic leukemia in whom a lengthy survival of 5 years was observed after treatment with splenic irradiation and chemotherapy. The patient obtained a surprising improvement with a significant reduction in the absolute count of the prolymphocytes and considerable reduction in splenomegaly after 3 months' therapy with interferon alpha.

[Burkitt's lymphoma with leukemic evolution]. / Linfoma di Burkitt ad evoluzione leucemica.

An account of the clinical, histopathological and aetiopathogenetic aspects of Burkitt's lymphoma is followed by the presentation of a personal case, in which the typical clinical picture of the African form progressed to terminal leukaemia. The aetiological and pathogenetic rôle of the Epstein-Barr virus is also briefly discussed.