RESUMO
BACKGROUND: A recent intriguing carcinogenetic hypothesis for lung cancer foresees its viral aetiology. The human papilloma virus (HPV) is the main virus actually recognised in the pathogenesis of lung cancer. The aim of this study was to investigate, for the first time to our knowledge, the presence of HPV in the exhaled breath condensate (EBC) of lung cancer patients. MATERIALS AND METHOD: We enrolled 89 patients affected by lung cancer and 68 controls. HPV infections were investigated in their EBC, paired bronchial brushing and neoplastic lung tissue through genotyping. RESULTS: We were able to detect HPV in the EBC, bronchial brushing and neoplastic lung tissue. We described the presence of an HPV infection in 16.4% of the subjects affected by non-small cell lung cancer, but in none of the controls. HPV 16 and 31 turned out to be the most widespread genotypes. The HPV positivity in airways as well as in the smoking habit was seen to independently increase the individual's susceptibility to developing lung cancer. CONCLUSION: When summing up, we demonstrated the possibility to identify an HPV infection in the EBC of lung cancer patients; further, we supported the notion that the EBC is a suitable tool to study airway colonisation. That being said, although further studies are needed to confirm our results, we retain the study of HPV in EBC to be very interesting in terms of future programmes involving lung-cancer screening.
Assuntos
Testes Respiratórios , Neoplasias Pulmonares/virologia , Papillomaviridae/isolamento & purificação , Idoso , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Inclusão em ParafinaRESUMO
Osteochondroma is the most common bone tumor of the foot. This should be easily recognized by foot and ankle specialists. Malignant transformation does occur, although it is quite rare, and should be a consideration when deciding on treatment. An unusual case of recurrent osteochondroma is reviewed.
Assuntos
Neoplasias Ósseas , Recidiva Local de Neoplasia , Osteocondroma , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Osteocondroma/diagnóstico , Osteocondroma/patologia , Osteocondroma/cirurgiaRESUMO
The spontaneous development of malignant non-Hodgkin lymphoma in a patient with idiopathic myelofibrosis is described. The tumor appeared 3 years after clinical diagnosis of the latter. Implications of the association between myeloproliferative and lymphoproliferative disorders at a pathogenetic level are briefly discussed.