Volumetric Classification: Unveiling the True Extent of Rotator Cuff Tears.

INTRODUCTION: Rotator cuff injury diagnosis involves comprehensive clinical, physical, and imaging assessments, with MRI being pivotal for detecting and classifying these injuries. However, the absence of a universally accepted classification system necessitates a more precise approach, advocating for the use of three-dimensional (3D) modeling to better understand and categorize rotator cuff tears. METHODOLOGY: This research was conducted as a prospective, single-institution study on 62 patients exhibiting full-thickness rotator cuff tears. Utilizing preoperative 1.5T MRI, the study aimed to create a more detailed classification system based on volumetric and surface area measurements. Advanced 3D modeling software was employed to transform MRI data into precise 3D representations, facilitating a more accurate analysis of the lesions. RESULTS: The study unveiled a novel classification system rooted in volumetric and surface area assessments, revealing significant discrepancies in the existing two-dimensional classifications. Approximately 45% of the cases demonstrated inconsistencies between traditional classifications and 3D measurements. Notably, medium-sized lesions were often overestimated, while small and large lesions were consistently underestimated in their severity. The volumetric and surface area-based classifications provided a more accurate depiction, highlighting the limitations of relying solely on coronal plane assessments in MRI. Comparative analysis confirmed the improved accuracy of the 3D method. CONCLUSION: The integration of 3D imaging and volumetric analysis offers novel advancement in diagnosing and classifying rotator cuff injuries. This study's findings challenge the conventional reliance on 2D MRI, proposing a more detailed and accurate classification system that enhances the precision of surgical planning and potentially improves patient outcomes. The incorporation of comprehensive 3D assessments into the diagnostic process represents a significant step forward in the orthopedic imaging field.

Can three-dimensional models enhance understanding and knowledge of rotator cuff tears?

OBJECTIVES: Magnetic resonance imaging (MRI) is currently the standard diagnostic tool for rotator cuff tears. However, its two-dimensional (2D) output, displayed on a monitor, can complicate the interpretation of anatomy. Three-dimensional (3D) imaging may offer a solution to this issue. This study aimed to demonstrate the diagnostic and interpretive value of a 3D model in assessing lesion anatomy. The hypothesis was that 3D models, compared to 2D MRI, can enhance the comprehension and knowledge of rotator cuff injuries, improve the application of classifications for total tears, and provide a more precise definition of the size and type of tear. METHODS: A prospective single-centre study was conducted. 3D models for rotator cuff tears were created and analysed in conjunction with preoperative MRI for each patient up to 2 months before surgery. The 3D models were based on the preoperative MRI. Collected data included 2D plane measurements by MRI in coronal and sagittal planes, descriptions of 3D lesion geometry (new shapes), 3D measurements in coronal and sagittal planes, arthroscopic classifications of rotator cuff injuries, and arthroscopic measurements in coronal and sagittal planes. RESULTS: After examining 25 cases, 3D imaging demonstrated similar arthroscopic values post-bursectomy in the sagittal plane (16.70 â€‹mm for 3D and 18.28 â€‹mm for post-bursectomy, p-value â€‹= â€‹0.189), although these measurements did not align with those of MRI (which underestimated measurements, p-value â€‹= â€‹0.010). Both MRI measurement and 3D imaging showed similar measurement accuracy in the coronal plane when compared to arthroscopic measurements taken before and after bursectomy. The creation of 3D objects enabled the analysis of new geometries, including the length, width, and depth of each lesion. These geometries included the rectangle, rectangular trapezoid, scalene trapezoid, irregular pentagon, and irregular hexagon. CONCLUSIONS: 3D models can enhance the understanding and knowledge of rotator cuff injuries. They can be a promising tool for diagnosing and interpreting the anatomy of the injury, particularly in the sagittal plane. The new 3D understanding of the pathological process has led to the description of new geometric features not visible in conventional 2D MRI. LEVEL OF EVIDENCE: II - Development of diagnostic criteria on consecutive patients (all compared to "gold" standard).

What is the best position for coracoid fixation in the Latarjet procedure?

Hypothesis: Multiple problems and complications associated with Latarjet fixation have been described; thus, this is the first study in the literature to identify the maximum allowed screw clamping force and best fixation screw position for Latarjet surgery. Methods: A variation of distal and proximal coracoid screw positions with and without a flat washer was evaluated through finite element analysis, at a minimum distance of 3 mm from the edge. A loading progression test was performed until the maximum stress reached a limit imposed by the bone yield. We identified the maximum allowed screw clamping force based on a von Mises and maximum principal stresses failure theory. Results: When using the flat washer, the cortical bone generally has only space for 1 piece. For this reason, as a primary study, it was observed that when the distal screw was more than 7 mm from the edge, the clamping force supported will be higher than that during the proximal fixation regardless of the proximal location screw. We have found that the best position is 7 mm from the distal edge, with the highest compression of 445 N (7 mm proximal distance, 5 mm distal distance) in due respect to the von Mises failure theory. To get around this lack of space situation, in this study, we have proposed a fixation plate to replace the flat washer. This plate has shown very interesting values when compared to the previously flat washer study, but now, for both screw holes. With those results, we can assure that using a fixation plate like this will ensure surgery safety and higher allowed compression force when clamping the bolts. Conclusion: The distal screw provided higher tensile strength values when located more than 7 mm from the coracoid edge. The geometry of the coracoid in its distal position supports higher stress loads than in the proximal position. When the flat washer was in the proximal position, the coracoid was submitted with a more distributed and uniform load, preventing localized bone damage as a crush.

Economic impact of covid-19 on brazilian orthopedists / Impacto econômico da covid-19 nos ortopedistas brasileiros

ABSTRACT Objective: The aim of this study is to assess the economic impact of the new coronavirus (COVID-19) on Brazilian Orthopaedic Surgeons. Methods: The questionnaire was applied to orthopedists and it questions how long they have worked in this area; their monthly financial impact during the pandemic; what sector was impacted the most; if they had or didn't have any financial reserves and how long they would last; if they had any other source of fixed income; and how much time off they had taken from work. It was entirely anonymous and it could only be answered once. Results: About 98% (955 out of 975) of the analyzed orthopedists suffered some monetary impact, 80% had a financial reserves, from which 45% could last for 3 months. Conclusion: There was a direct relationship between the professional experience in this subspecialty and a higher percentage of fixed income, as well as a greater impact on the reduction percentage in the monthly budget and a longer time off the job. Level of Evidence IV, Analyses with no sensitivity analyses.

RESUMO Objetivo: Avaliar o impacto econômico do novo coronavírus (Covid-19) entre ortopedistas brasileiros. Métodos: Questionário aplicado a ortopedistas que aborda o tempo de prática clínica, impacto no orçamento mensal durante o mês inicial da pandemia, setor de maior impacto, presença de outra fonte de renda fixa na área médica ou fora, existência de reserva financeira, previsão de tempo de afastamento e expectativa de retorno às atividades normais. Todo formulário é anônimo e programado para ser respondido apenas uma vez. Resultados: Cerca de 98% (955, entre 975 que responderam ao questionário) dos médicos ortopedistas analisados sofreram algum impacto monetário, 80% tinham reserva financeira, 45% dentre eles com reserva financeira para até 3 meses. Conclusão: Existiu uma relação direta entre o maior tempo de subespecialidade, a maior porcentagem de renda fixa, o maior impacto na porcentagem de redução no salário mensal e o maior o tempo de afastamento. Nível de Evidência IV, Análises sem análises de sensibilidade.

Bilateral Erecta Luxation: A Case Report and Literature Review.

CASE: A 69-year-old man fell from a height, resulting in direct axial loading while both shoulders were fully abducted. He was referred to the surgical ward, and both shoulders were reduced by closed reduction using the traction-countertraction maneuver. After little improvement of complaints of pain in the right shoulder over 45 days, magnetic resonance demonstrated traumatic rupture of the supraspinatus. CONCLUSION: Inferior dislocation (luxation erecta) is an uncommon event, with bilateral dislocation being even rarer. Treatment should be initiated urgently via closed reduction or, if this is not possible, through open reduction. The long-term prognosis is favorable after appropriate treatment.

Prospective evaluation of periarticular hyaluronic acid infiltration for the treatment of lateral epicondylitis / Avaliação prospectiva da infiltração periarticular de ácido hialurônico para o tratamento da epicondilite lateral

ABSTRACT Objective: To prospectively, clinically and functionally follow-up patients previously diagnosed with lateral epicondylitis after periarticular application of hyaluronic acid and analyze the results. Methods: All patients were previously treated conservatively and had no clinical improvement. Data such as age, positivity for specific tests (Cozen and Mill), visual analogue pain scale (VAS) before and during dorsiflexion of the wrist with resistance, diagnosis time, Mayo Elbow Performance Score was collected. Patients were reevaluated 30 and 90 days after application. Results: The positivity rates for Cozen and Mill tests were identical, starting at 100%, dropping to 50% after one month, and ending at 41.7% after 3 months. The initial Mayo Elbow Score average was 61.3 points; 85.8 in the first month, remaining at 85 in the third month. VAS in active force situations had the initial average of 8.1; after one month it dropped to 3.8, and 3.6 after three months. At rest, the initial average was 5.9; after one month it decreased to 3 and ended at 2.1 in three months. Conclusion: Patients showed improvement in pain parameters, in the Mayo Elbow Performance Score standard, but with 25% of failure in satisfaction. Level of evidence IV, Case series.

RESUMO Objetivo: Acompanhar de maneira prospectiva, clínica e funcionalmente, os pacientes previamente diagnosticados com epicondilite lateral após a aplicação periarticular de ácido hialurônico e analisar os resultados. Métodos: Todos pacientes foram tratados previamente de maneira conservadora e não obtiveram melhora clínica. Foram coletados idade, positividade nos testes específicos (Cozen e Mill), escala visual analógica da dor (EVA) antes e durante a dorsoflexão contrarresistência do punho, tempo de diagnóstico, Mayo Elbow Performance Score. Os pacientes foram reavaliados após 30 e 90 dias das aplicações. Resultados: Os índices de positividade para os testes de Cozen e Milll foram idênticos, começaram em 100%, caíram para 50% após 1 mês, e terminaram em 41,7% em 3 meses. A média inicial do Mayo Elbow Score foi 61,3 pontos; 85,8 no primeiro mês e manteve-se em 85 no terceiro mês. A EVA em situações de força ativa teve a média inicial de 8,1; após 1 mês caiu para 3,8, e 3,6 em 3 meses. Em repouso, a média inicial foi 5,9; após 1 mês diminui para 3, e terminou com 2,1 em 3 meses. Conclusão: Os pacientes apresentaram melhora nos parâmetros de dor, no padrão Mayo Elbow Performance Score, mas com 25% de falha na satisfação. Nível de evidência IV, Série de casos .

LATARJET PROCEDURE ON ANTERIOR SHOULDER INSTABILITY IN PROFESSIONAL SOCCER PLAYERS.

Anterior glenohumeral instability is a frequent cause of professional soccer players' removal, reduced performance, and prolonged recovery. Players are subjected to intense physical contact and high performance, thus demanding lower rates of recurrence after surgical correction so they can return to sport quickly. OBJECTIVE: To assess professional soccer players treated by the Lartajet technique considering the rate and time of return to sports activities, complications or failures. METHODS: Analysis held between 2010 and 2018 of professional soccer players diagnosed with anterior shoulder instability operated by the open procedure of Lartajet in our service. RESULTS: The mean return to professional sports was 93.5 days. The mean time of surgery in relation to the first dislocation was 12.4 months. Each athlete had 4.3 shoulder dislocations until the procedure was performed. The rate of recurrence was zero and subluxation was not observed. CONCLUSION: The Latarjet procedure allowed all professional athletes to return to competitive activities quickly, without dislocations and subluxation, negative seizure and without complications during follow-up. Level of evidence IV, Case series.

A instabilidade glenoumeral anterior é uma frequente causa de afastamento dos jogadores de futebol profissional, redução do desempenho e recuperação prolongada. Os jogadores são submetidos ao contato físico intenso e ao alto desempenho, sendo assim necessário atingir menores taxas de recidiva após a correção cirúrgica e retorno ao esporte de forma mais rápida. OBJETIVO: Avaliar jogadores de futebol profissionais tratados pela técnica de Lartajet com análise da taxa e tempo de retorno às atividades esportivas, complicações ou falhas. MÉTODOS: Análise entre 2010 a 2018 de dez jogadores de futebol que estão atuando em clubes profissionais, diagnosticados por instabilidade anterior do ombro operados pelo procedimento aberto de Lartajet em nosso serviço. RESULTADOS: A média de retorno ao esporte profissional foi de 93,5 dias. A média de tempo da cirurgia em relação ao primeiro episódio de luxação foi de 12,4 meses. Cada atleta teve 4,3 luxações de ombro até o procedimento ser realizado. A taxa de recidivas foi zero e não foi observada subluxação. CONCLUSÃO: O procedimento Latarjet propiciou que todos os atletas profissionais de futebol retornassem às atividades competitivas de maneira rápida, sem recidivas das luxações e subluxações e sem complicações durante o acompanhamento realizado. Nível de evidência IV, Séries de casos.

Latarjet procedure on anterior shoulder instability in professional soccer players / Cirurgia de latarjet na instabilidade anterior do ombro em jogadores profissionais de futebol

ABSTRACT Anterior glenohumeral instability is a frequent cause of professional soccer players' removal, reduced performance, and prolonged recovery. Players are subjected to intense physical contact and high performance, thus demanding lower rates of recurrence after surgical correction so they can return to sport quickly. Objective: To assess professional soccer players treated by the Lartajet technique considering the rate and time of return to sports activities, complications or failures. Methods: Analysis held between 2010 and 2018 of professional soccer players diagnosed with anterior shoulder instability operated by the open procedure of Lartajet in our service. Results: The mean return to professional sports was 93.5 days. The mean time of surgery in relation to the first dislocation was 12.4 months. Each athlete had 4.3 shoulder dislocations until the procedure was performed. The rate of recurrence was zero and subluxation was not observed. Conclusion: The Latarjet procedure allowed all professional athletes to return to competitive activities quickly, without dislocations and subluxation, negative seizure and without complications during follow-up. Level of evidence IV, Case series.

RESUMO A instabilidade glenoumeral anterior é uma frequente causa de afastamento dos jogadores de futebol profissional, redução do desempenho e recuperação prolongada. Os jogadores são submetidos ao contato físico intenso e ao alto desempenho, sendo assim necessário atingir menores taxas de recidiva após a correção cirúrgica e retorno ao esporte de forma mais rápida. Objetivo: Avaliar jogadores de futebol profissionais tratados pela técnica de Lartajet com análise da taxa e tempo de retorno às atividades esportivas, complicações ou falhas. Métodos: Análise entre 2010 a 2018 de dez jogadores de futebol que estão atuando em clubes profissionais, diagnosticados por instabilidade anterior do ombro operados pelo procedimento aberto de Lartajet em nosso serviço. Resultados: A média de retorno ao esporte profissional foi de 93,5 dias. A média de tempo da cirurgia em relação ao primeiro episódio de luxação foi de 12,4 meses. Cada atleta teve 4,3 luxações de ombro até o procedimento ser realizado. A taxa de recidivas foi zero e não foi observada subluxação. Conclusão: O procedimento Latarjet propiciou que todos os atletas profissionais de futebol retornassem às atividades competitivas de maneira rápida, sem recidivas das luxações e subluxações e sem complicações durante o acompanhamento realizado. Nível de evidência IV, Séries de casos.

Kirschner Wire Migration after the Treatment of Acromioclavicular Luxation for the Contralateral Shoulder - Case Report.

The use of metal wires, called Kirschner wires, is a simple and effective fixation method for the correction of shoulder fractures and of dislocations in orthopedic surgery. Wire migration during the postoperative follow-up is a possible complication of the procedure. The authors present the case of a 48-year-old male patient, a business administrator, who suffered a fall from his own height during a soccer match resulting in right shoulder trauma. The patient was treated at a specialized orthopedics and trauma hospital and was diagnosed with a grade V acromioclavicular dislocation. Four days after the trauma, the acromioclavicular dislocation was surgically treated using ligatures with anchor wires, coracoacromial ligament transfer, and fixation with Kirshner wires from the acromion to the clavicle. At the follow-up, 12 days after the surgical procedure, migration of the Kirschner wire to the acromion edge was identified. The patient was oriented to undergo another surgery to remove the Kirshner wire, due to the possibility of further migration; nonetheless, he refused the surgery. Nine months after the surgical treatment, the patient complained of pain on the left shoulder (contralateral side), difficulty to mobilize the shoulder, ecchymosis, and protrusion. Bilateral radiographs demonstrated that the Kirschner wire, originally from the right shoulder, was on the left side. The patient then underwent a successful surgery to remove the implant.

Kirschner Wire Migration after the Treatment of Acromioclavicular Luxation for the Contralateral Shoulder - Case Report / Migração do fio de Kirschner após o tratamento da luxação acromioclavicular para o ombro contralateral - relato de caso

Abstract The use of metal wires, called Kirschner wires, is a simple and effective fixation method for the correction of shoulder fractures and of dislocations in orthopedic surgery.Wire migration during the postoperative follow-up is a possible complication of the procedure. The authors present the case of a 48-year-old male patient, a business administrator, who suffered a fall from his own height during a soccer match resulting in right shoulder trauma. The patient was treated at a specialized orthopedics and trauma hospital and was diagnosed with a grade V acromioclavicular dislocation. Four days after the trauma, the acromioclavicular dislocation was surgically treated using ligatures with anchor wires, coracoacromial ligament transfer, and fixation with Kirshner wires from the acromion to the clavicle. At the follow-up, 12 days after the surgical procedure, migration of the Kirschner wire to the acromion edge was identified. The patient was oriented to undergo another surgery to remove the Kirshner wire, due to the possibility of further migration; nonetheless, he refused the surgery. Nine months after the surgical treatment, the patient complained of pain on the left shoulder (contralateral side), difficulty tomobilize the shoulder, ecchymosis, and protrusion. Bilateral radiographs demonstrated that the Kirschner wire, originally from the right shoulder, was on the left side. The patient then underwent a successful surgery to remove the implant.

Resumo O uso dos fios metálicos, denominados fios de Kirschner, é um método de fixação simples e eficaz para a correção de fraturas e luxações do ombro na cirurgia ortopédica. Uma das possíveis complicações é a migração do fio durante o acompanhamento pósoperatório. Os autores apresentam um caso de um paciente masculino de 48 anos, administrador, que sofreu uma queda de mesmo nível com trauma em ombro direito durante uma partida de futebol. Atendido emumhospital de referência de ortopedia e traumatologia, foi diagnosticada luxação acromioclavicular grau V. Quatro dias após o trauma, fez-se o tratamento cirúrgico da luxação acromioclavicular com amarrilhos com fios de âncora, transferência do ligamento coracoacromial e fixação com fio de Kirchner do acrômio à clavícula. No retorno, 12 dias após o procedimento cirúrgico, identificou-se amigração do fio de Kirschner do bordo do acrômio. Apesar de orientado a se submeter a cirurgia para remoção do fio, o paciente se recusou.Novemeses após o tratamento cirúrgico, o paciente apresentou dores no ombro esquerdo (lado contralateral), dificuldade para mobilizar o ombro, equimose e saliência. Foram feitas radiografias bilaterais e foi constatado que o fio de Kirschner, originalmente no ombro direito, estava no ombro contralateral. Fez-se então cirurgia para remoção do implante, com sucesso.

Surgical treatment of femoral head fractures through previously controlled hip luxation: four case series and literature review / Tratamento cirúrgico das fraturas da cabeça femoral através da luxação anterior controlada do quadril - Série de quatro casos e revisão da literatura

ABSTRACT Objective To report a series of cases of patients treated by fracture of the femoral head through the Ganz pathway with controlled dislocation of the hip. Method All patients who were surgically treated with a Ganz access route for femoral head fractures were identified in a tertiary referral service for trauma. A review of medical records with X-rays and CT scans was carried out. The radiographic evaluation was classified according to Pipkin and the functional evaluation was performed through the application of the modified Harris Hip Score. Data regarding the quality of reduction, type of fixation, and postoperative complications were collected. Results The sample consisted of three men and one woman, with a mean age of 30 years (20-51). Regarding Pipkin's classification, two cases were type I, one type II, and one type IV. Regarding the Harris Hip Score, an average of 65.75 points was obtained (range: 20-86). All cases had anatomical reduction in the intraoperative period. One case presented post-traumatic sciatic nerve praxis and evolved with infection at the surgical site. Conclusion Surgical treatment of femoral head fractures through controlled hip dislocation is a viable option and can be considered an alternative to classical approaches.

RESUMO Objetivo Relatar uma série de casos de pacientes com fratura da cabeça femoral tratados através da via de Ganz com luxação controlada do quadril. Método Identificaram-se todos os pacientes tratados cirurgicamente com via de acesso de Ganz para fraturas da cabeça femoral em um serviço terciário referência em trauma. Fez-se uma revisão de prontuários com as radiografias e tomografias computadorizada. A avaliação radiográfica foi classificada de acordo com Pipkin e a avaliação funcional foi feita com o Harris Hip Score modificado. Foram coletados dados referentes à qualidade de redução, ao tipo de fixação e às complicações pós-operatórias. Resultados A amostra foi composta por três homens e uma mulher, com média de 30 anos (20-51). Em relação à classificação de Pipkin, dois casos eram do tipo I, um do tipo II e um do tipo IV. Em relação ao Harris Hip Score, observou-se uma média de 65,75 pontos (20 a 86). Todos os casos obtiveram redução anatômica no intraoperatório. Um caso apresentou praxia do nervo ciático pós-trauma e evoluiu com infecção do sítio cirúrgico. Conclusão O tratamento cirúrgico das fraturas da cabeça do fêmur através da luxação controlada do quadril é uma opção viável e pode ser considerada uma opção às vias clássicas de abordagem.

Intra-articular viscosupplementation of hyaluronic acids in an experimental osteoarthritis model / Viscossuplementação intra-articular de ácidos hialurônicos em modelo experimental de osteoartrite

ABSTRACT Objective: To analyze, from the immunohistochemical perspective, the effects of hyaluronic acid of different molecular weights in an experimental model of osteoarthritis in rabbits. Methods: Forty-four male California rabbits were randomly assigned to three different groups (PR, S, and P) and submitted to the resection of the anterior cruciate ligament of the right knee. Three weeks after the surgical procedure, three intra-articular weekly injections were carried out with low-molecular-weight native hyaluronic acid (Hyalgan®) to PR group, high molecular weight branched chain hyaluronic acid (Synvisc®) to group S, and saline solution 0.9% to group P. All animals were sacrificed 12 weeks after the surgical procedure, and the tibial plateaus of the infiltrated knees were then dissected. Histological sections of cartilage from the tibial plateau support areas were stained with immunohistochemical markers in order to investigate the amount of metalloproteases (MMPs 3 and 13) and their inhibitors (TIMPs 1 and 3). The staining intensity was quantified on a Zeiss Imager.Z2 Metasystems microscope and analyzed by Metafer4 Msearch software. Results: The chondroprotective effect of the hyaluronic acids used in the study was demonstrated when compared to the control group. However, the comparison between them presented no significant statistical difference regarding chondroprotection. Conclusion: The injection of saline solution demonstrated signs of OA development, while adding native hyaluronic acid of low molecular weight (Hyalgan®) and hyaluronic acid of high molecular weight (Synvisc®) protected the articular cartilage in this model of OA.

RESUMO Objetivo: Analisar do ponto de vista imuno-histoquímico os efeitos do ácido hialurônico de diferentes pesos moleculares em modelo experimental em coelhos. Métodos: Foram alocados de modo aleatório 44 coelhos da raça California, machos, em três grupos (PR, S e P), e submetidos à ressecção do ligamento cruzado anterior do joelho direito. Decorridas três semanas do procedimento cirúrgico iniciaram-se as três injeções intra-articulares semanais de ácido hialurônico nativo de baixo peso molecular (Polireumin®) no grupo PR, ácido hialurônico de cadeia ramificada de alto peso molecular (Synvisc®) no grupo S e soro fisiológico 0,9% no grupo P. Todos os animais foram sacrificados após 12 semanas do ato cirúrgico e os platôs tibiais dos joelhos infiltrados foram dissecados. Cortes histológicos da cartilagem das áreas de apoio dos platôs tibiais foram corados com marcadores imuno-histoquímicos para pesquisa da quantidade de metaloproteases (MMPs-3,13) e seus inibidores (TIMPs-1,3). A intensidade de coloração foi quantificada em um aparelho de microscopia Zeiss Imager.Z2 Metasystems e analisada pelo software Metafer4 Msearch. Resultado: O efeito condroprotetor dos ácidos hialurônicos usados no estudo foi demonstrado quando comparados com o grupo controle, porém feita a comparação entre si não houve diferença estatística significante quanto à condroproteção. Conclusão: A injeção de solução salina demonstra sinais de desenvolvimento de OA enquanto que a adição de ácido hialurônico nativo de baixo peso molecular (Polireumin®) e ácido hialurônico de cadeia ramificada de alto peso molecular (Synvisc®) protegeram a cartilagem articular nesse modelo de OA.