Primary repair with no flaps for lower lip defects (30-80 %) after cancer excision.

Reconstruction of the lip is a necessary procedure when lip tumors are excised. Although many good techniques have been described, they often have disadvantages such as necrosis and extensive suture lines. In our approach, we aim to minimize the suture line and avoid tissue necrosis for medium-sized lip defects (30-80 %). This is a surgical technique report from a single center. After tumor resection, we made a bilateral 15 mm horizontal skin and mucosa incision from the angles of the lip to the lateral sides. The mucosa and skin were dissected from the underlying muscle, and the muscle was cut approximately 15 mm on each side. The lip defect was then closed and sutured in four layers. Finally, the released mucosa was sutured to the corner of the incised skin. We followed the patients for 36 months and found that their speech intelligibility, sensation, mobility, and aesthetic satisfaction were preserved. The scars were also less pronounced compared to flaps, and there were no signs of edema or drooling. In conclusion, our technique offers many advantages for moderate defects of lower lip tumors. By avoiding the use of flaps, we eliminate the complications associated with flap surgery while achieving aesthetically satisfactory results. However, further evaluation by other surgeons is necessary to fully examine the technique's benefits.

Six degrees of freedom intrafraction cranial motion detection using a novel capacitive monitoring technique: evaluation with human subjects.

The purpose of this work is to introduce and evaluate a capacitive monitoring array capable of continuous 6DOF cranial motion detection during high precision radiotherapy. The ring-shaped capacitive array consists of four equally sized conductive sensors positioned at the cranial vertex. The system is modular, non-contact, and provides continuous motion information through the thermoplastic immobilization mask without relying on skin monitoring or use of ionizing radiation. The array performance was evaluated through a volunteer study with a cohort of twenty-five individuals. The study was conducted in a linac suite and the volunteers were fitted with an S-frame thermoplastic mask. Each volunteer took part in one data acquisition session per day for three consecutive days. During the data acquisition, the conductive array was translated and rotated relative to their immobilized cranium in 1-millimetre and 1-degree steps to simulate cranial motion. Capacitive signals were collected at each position at a frequency of 20 Hz. The data from the first acquisition session was then used to train a classifier model and establish calibration equations. The classifier and calibration equations were then applied to data from the subsequent acquisition sessions to evaluate the system performance. The trained classifiers had an average success rate of 92.6% over the volunteer cohort. The average error associated with calibration had a mean value below 0.1 mm or 0.1 deg for all six motions. The capacitive array system provides a novel method to detect translational and rotational cranial motion through a thermoplastic mask.

Finite element analysis of a capacitive array for 6D intrafraction motion detection during stereotactic radiosurgery.

This work presents a non-contact, non-ionizing solution for the continuous detection and characterization of intrafraction cranial motion with six-degrees of freedom (DoF). This capacitive monitoring system is a modular tool capable of detecting the cranial position through a thermoplastic mask without the use of skin as a surrogate. The purpose of this investigation is to develop an array of capacitive monitoring sensor plates capable of detecting translational and rotational cranial motion during radiotherapy. This study compares the performance of different capacitive monitoring array designs for their potential to detect intrafraction cranial translations and rotations. To this end, a finite element analysis (FEA) model of the human cranium was used to calculate the system capacitance while simulating translational (superior-inferior, lateral, anterior-posterior) and rotational (roll, pitch, yaw) cranial motion. The model was validated by comparing simulation results against experimental results acquired with the help of human volunteers. The verified FEA model was then used to compare multiple potential array designs. The arrays' sensitivities to translational and rotational motion and uniqueness of response were compared to determine the most promising design for six-DoF motion detection. The most promising array design was chosen for a clinical volunteer study.

Unveiling Charles II, the last King of the Habsburg Spanish Empire, in a portrait by Juan Carreño de Miranda (1685).

PURPOSE: Charles II (1661-1700) was the last King of the Habsburg dynasty. He was physically and mentally disabled and died at just 39 years old. Here, the authors attempt to investigate the correlations between his signs and symptoms and the physical appearance on the painting. METHODS: Charles II has been portraited by Juan Carreño de Miranda in a painting that may provide precious information about his premature death. RESULTS: It has been suggested that inbreeding beside other endocrinological disorders were of the major causes responsible for illness and ultimately his death. CONCLUSION: Possible endocrinological diseases have been hypothesized.

A novel intra-fraction motion monitoring system for stereotactic radiosurgery: proof of concept.

The purpose of this work is to develop a prototype system for continuous, three-dimensional (3D) monitoring of patient cranial motion during stereotactic radiosurgery. Using novel capacitive detector plates, the goal was to provide detection of cranial position inside a thermoplastic immobilizing mask, without relying on skin monitoring or use of ionizing radiation. A novel capacitive detector array was used to detect cranial translations with sub-millimeter accuracy. The array was comprised of four conductive plates arranged around the cranium. One superior plate was positioned at the cranial vertex, two lateral plates were positioned in sagittal planes at the lateral aspects of the cranium and one plate was located in a coronal plane anterior to the face. The system was calibrated by parameterizing a capacitive signal for each dimension as a function of spatial translation. The detector array performance was evaluated with the help of a volunteer in the absence of radiation. Separately, possible effects of electromagnetic interference and irradiation in the linac suite were assessed. Detector plates mounted at 1 cm original distance to the thermoplastic mask can detect sub-millimeter lateral and superior cranial motion. Detection of sub-millimeter anterior motion is possible when the plate is mounted closer to the patient (5-10 mm). No signal interference was observed when the capacitive array was irradiated. Our prototype detector array provides continuous, 3D translation detection with sub-millimeter precision. The signal provides sufficient signal to noise ratio and is stable in linac room environment and in direct radiation beam. The detector plate is sensitive to the position of the cranium inside a mask and offers the advantage of being insensitive to the mask itself. Future work will involve modifying the array to detect patient rotation.

Perioperative complications associated with brachial plexus repair in infants.

This report details the complications experienced during 100 consecutive cases of brachial plexus surgery in infants. There were eight perioperative complications. There was no mortality or permanent sequelae from any complication.

Delay in diagnosis: indeterminate leprosy presenting with rheumatic manifestations.

BACKGROUND: Rheumatic complications are common in leprosy (Hansen's disease) and can be the primary complaint delaying accurate diagnosis. OBJECTIVE: Such a case is reported here: a 61-year-old woman with indeterminate leprosy presented with symmetric arthritis and purpura. Despite biopsy and evaluation by several physicians, leprosy was not suspected. After 2 years of progressive symptoms, a second biopsy revealed lepromatous leprosy. CONCLUSION: In this case, lack of clinical suspicion and unfamiliarity with the histology of indeterminate leprosy delayed diagnosis and treatment. Leprosy should be considered in the differential diagnosis of patients presenting with unusual rheumatic and persistent cutaneous manifestations.

Anesthesia is a risk factor for drug and alcohol craving and relapse in ex-abusers.

Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that opioids given during and after surgery may reinstate craving for, and initiate subsequent seeking of, heroin in former abusers. There are a substantial number of animal studies and some human studies documenting a reinstatement phenomenon in which an experimenter-administered psychoactive drug can precipitate drug-seeking behavior in 'abstinent' animals and humans. There is concern amongst health professionals and patients alike on this issue, and we discuss possible avenues of research, both preclinical and clinical, to explore the validity of our hypothesis.