Prospective derivation and validation of a NECROtizing Soft tissue InfectionS (NECROSIS) score: An EAST multicenter trial.

BACKGROUND: Although several risk indices have been developed to aid in the diagnosis of NSTIs, these instruments suffer from varying levels of reproducibility and failure to incorporate key clinical variables in model development. The objective of this study was to derive and validate a clinical risk index score - NECROSIS - for identifying NSTIs in emergency general surgery (EGS) patients being evaluated for severe skin and soft tissue infections. METHODS: We performed a prospective study across 16 sites in the US of adult EGS patients with suspected NSTIs over a 30-month period. Variables analyzed included demographics, admission vitals and labs, physical exam, radiographic, and operative findings. The main outcome measure was the presence of NSTI diagnosed clinically at the time of surgery. Multivariate analysis was performed to identify independent predictors for the presence of NSTI using the Hosmer-Lemeshow test and the Akaike information criteria. RESULTS: Of 362 patients, 297 (82%) were diagnosed with a NSTI. Overall mortality was 12.3%. Multivariate analysis identified 3 independent predictors for NSTI: systolic blood pressure ≤ 120 mmHg, violaceous skin, and WBC ≥15 (x103/uL). Multivariate modelling demonstrated Hosmer-Lemeshow goodness of fit (p = 0.9) with a c-statistic for the prediction curve of 0.75. Test characteristics of the NECROSIS score were similar between the derivation and validation cohorts. CONCLUSION: NECROSIS is a simple and potentially useful clinical index score for identifying at-risk EGS patients with NSTIs. Future validation studies are warranted. LEVEL OF EVIDENCE: Diagnostic Tests or Criteria, Level III.

Duration of antimicrobial treatment for complicated intra-abdominal infections after definitive source control: A systematic review, meta-analysis, and practice management guideline from the Eastern Association for the Surgery of Trauma.

BACKGROUND: Recent studies have evaluated outcomes associated with duration of antimicrobial treatment for complicated intra-abdominal infections (cIAI). The goal of this guideline was to help clinicians better define appropriate antimicrobial duration in patients who have undergone definitive source control for cIAI. METHODS: A working group of Eastern Association for the Surgery of Trauma (EAST) performed a systematic review and meta-analyses of the available data pertaining to the duration of antibiotics after definitive source control of cIAI in adult patients. Only studies that compared patients treated with short vs. long duration antibiotic regimens were included. The critical outcomes of interest were selected by the group. Noninferiority of short compared with long duration of antimicrobial treatment was defined as an indicator for a potential recommendation in favor of shorter antibiotics course. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the quality of the evidence and to formulate recommendations. RESULTS: Sixteen studies were included. The short duration ranged from 1 dose to ≤10 days, with an average of 4 days, and the long duration ranged >1 day to 28 days, with an average of 8 days. There were no differences between short and long duration of antibiotics in terms of mortality (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.56-1.44), rate of surgical site infection (OR, 0.88; 95% CI, 0.56-1.38); persistent/recurrent abscess (OR, 0.76; 95% CI, 0.45-1.29); unplanned interventions (OR, 0.53; 95% CI, 0.12-2.26); hospital length of stay (mean difference, -2.62 days; CI, -7.08 to 1.83 days); or readmissions (OR, 0.92; 95% CI, 0.50-1.69). The level of evidence was assessed as very low. CONCLUSION: The group made a recommendation for shorter (four or less days) versus longer duration (eight or more days) of antimicrobial treatment in adult patients with cIAIs who had definitive source control. LEVEL OF EVIDENCE: Systematic Review and Meta-Analysis; Level III.

A Massive Para-Esophageal Hernia: An Unusual Cause of Tension Physiology Leading to Cardiac Arrest.

Here, we describe the case of a 28-year-old man with history of super morbid obesity and Type IV para-esophageal hernia, who experienced cardiac arrest following incarceration and strangulation of his hernia sac. He required emergency surgery including an exploratory laparotomy and thoracotomy, with splenectomy, omentectomy, and partial gastrectomy. He was subsequently transferred to our institution due to the anticipated difficulty of restoring intestinal continuity. Continuity was established with a retrocolic Roux-en-Y reconstruction with a 90 cm Roux limb. Despite significant soft-tissue necrosis, he eventually recovered and was able to be transferred back to pursue rehabilitation closer to his home in a rural community.

What do the people who transport trauma patients know about tourniquets?

BACKGROUND: The primary study objectives were to gather information concerning the tourniquet knowledge, experience, training, protocols, preferences, and equipment of civilian prehospital providers. METHODS: This is a survey of 151 prehospital care providers. RESULTS: Survey respondents included 27 basic, 1 intermediate, and 75 paramedic emergency medical technicians; 1 registered nurse; 4 firefighters without medical certifications; 2 respondents not yet certified; and 1 respondent not listing certifications. Respondents had 2 months to 40 years of experience and came from emergency medical services in communities of 101 to 206,688 residents located 10 minutes to 103 minutes from a Level 1 or 2 trauma center. Twenty-five had used tourniquets: 5 in military and 22 in civilian settings. Civilian tourniquets were most frequently used for motor vehicle- then farm- and manufacturing-related injuries with severe bleeding. Tourniquet knowledge was poor for all groupings (with or without tourniquet experience, military experience, all certifications, all years of experience): 91% did not understand that wider tourniquets require less pressure for arterial occlusion, 69% did not know that stopping venous flow without arterial is harmful, and 37% did not know the correct tourniquet locations for distal limb injuries. Of the 81 on a service and without military experience, 44 had received any tourniquet training; 14 of the 44 had commercial emergency tourniquet access, and 27 indicated their service had a tourniquet protocol. Of the 37 on a service with no tourniquet training, 5 had access to a commercial emergency tourniquet, and 5 indicated their service had a tourniquet protocol. CONCLUSION: Civilian prehospital providers encounter situations for tourniquet use, but many do not know information important for optimal tourniquet use. Therefore, if surgeons want civilian prehospital care to include the use of effective, arterial flow occluding tourniquets at appropriate limb locations, they need to communicate with their emergency medical service providers concerning tourniquet knowledge, training, protocols, and appropriate equipment.