Quantitative and qualitative analysis of neuroinflammation by beta amyloid1-42 toxin after treatment with resveratrol-loaded nanoparticles / Análise quantitativa e qualitativa da neuroinflamação pela toxina beta amilóide1-42 após tratamento com nanopartículas de resveratrol

Background: This study evaluated the effects of zein nanoparticles with resveratrol on neuroinflammation caused by Alzheimer's disease. Method: The sample consisted of 30 animals divided into control (C), positive control (CP), white nanoparticles (NB), resveratrol nanoparticles (NR) and resveratrol (R) groups. The animals received 10 mg/kg of resveratrol or nanoparticles according to the group, daily, for 15 days, oral administration. Afterward, they were submitted to immunohistochemical (IHC) analyses. Results: the IHC showed that there was no change in the morphological brain composition in the NR and C groups. Conversely, in the CP, NB, and R groups, changes in the deposition of Anti Tau were observed. The NR group showed a normal projection of taurine in the axon, which was not presented in the same way in the other groups. The CD68 marker showed no microglial activation in the R and C groups. Quantitative analyses of Anti Beta-Amyloid in the NR group showed a statistical difference com-pared to the CP, NB, and R groups, whereas the Anti Tau analysis showed a significant difference between the CP and NR groups. The CD68 marker showed a significant difference between the C and NR groups. The analysis of cy-tokines showed a significant difference in TNF-α between the C and CP groups, C and NB groups, CP and NR groups, and NB and NR groups. IL-6 and InF-δ showed no significant difference between all groups. IL-10 showed significant differences between the C and NR groups, C and R groups, and CP and NR groups. Conclusion: NR prevented the evolution of neuroinflammation(AU).

Introdução: Este estudo avaliou os efeitos das nanopartículas de zeína com resveratrol na neuroinflamação causada pela doença de Alzheimer. Método: A amostra consistiu em 30 animais divididos em grupos de controle (C), controle positivo (CP), nanopartículas brancas (NB), nanopartículas de resveratrol (NR) e resveratrol (R). Os animais receberam 10 mg/kg de resveratrol ou nanopartículas de acordo com o grupo, diariamente, por 15 dias, por via oral. Em seguida, foram submetidos a análises imuno-histoquímicas (IHC). Resultados: A IHC mostrou que não houve alteração na composição morfológica do cérebro nos grupos NR e C. Por outro lado, nos grupos CP, NB e R, foram observadas alterações na deposição de Anti Tau. O grupo NR mostrou uma projeção normal de taurina no axônio, que não se apresentou da mesma forma nos outros grupos. O marcador CD68 não mostrou ativação microglial nos grupos R e C. As análises quantitativas do antibeta-amiloide no grupo NR mostraram uma diferença estatística quando comparadas aos grupos CP, NB e R, enquanto a análise do antitau mostrou uma diferença significativa entre os grupos CP e NR. O marcador CD68 mostrou uma diferença significativa entre os grupos C e NR. A análise das citocinas mostrou uma diferença significativa no TNF-α entre os grupos C e CP, C e NB, CP e NR, e NB e NR. IL-6 e InF-δ não apresentaram diferença significativa entre todos os grupos. A IL-10 apresentou diferenças significativas entre os grupos C e NR, C e R, e CP e NR. Conclusão: A NR impediu a evolução da neuroinflamação (AU).

Gentle Touch Therapy, Pain Relief and Neuroplasticity at Baseline in Fibromyalgia Syndrome: A Randomized, Multicenter Trial with Six-Month Follow-Up.

BACKGROUND: Fibromyalgia (FM) is considered a stress-related disorder characterized mainly by chronic widespread pain. Its pathogenesis is unknown, but cumulative evidence points at dysfunctional transmitter systems and inflammatory biomarkers that may underlie the major symptoms of the condition. This study aimed to evaluate pain scores (primary outcome), quality of life, inflammatory biomarkers and neurotransmitter systems in women with FM (secondary outcomes) subjected to gentle touch therapy (GTT) or placebo. METHODS: A total of 64 female patients with FM were randomly assigned to two groups, namely GTT (n = 32) or Placebo (n = 32). Clinical assessments were conducted at baseline and post-intervention with six-month follow-up. We measured serum catecholamines (dopamine), indolamines and intermediary metabolites (serotonin or 5-hydroxyindolacetic acid (5-HIAA)), as well as tetrahydrobiopterin (BH4), which is a cofactor for the synthesis of neurotransmitters and inflammatory biomarkers in women with FM. A group of healthy individuals with no intervention (control group) was used to compare biochemical measurements. Intervention effects were analyzed using repeated measures (RM) two-way ANOVA followed by Bonferroni post hoc test and mixed ANCOVA model with intention to treat. RESULTS: Compared to placebo, the GTT group presented lower pain scores and brain-derived neurotrophic factor (BDNF) levels without altering the quality of life of women with FM. Changes in BDNF had a mediating role in pain. Higher baseline serum BDNF and 5-HIAA or those with a history of anxiety disorder showed a higher reduction in pain scores across time. However, women with higher serum dopamine levels at baseline showed a lower effect of the intervention across the observation period revealed by an ANCOVA mixed model. CONCLUSIONS: In conclusion, lower pain scores were observed in the GTT group compared to the placebo group without altering the quality of life in women with FM. Reductions in BDNF levels could be a mechanism of FM pain status improvement. In this sense, the present study encourages the use of these GTT techniques as an integrative and complementary treatment of FM.

Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice.

Objective: Complex regional pain syndrome (CRPS) is usually triggered by trauma or a surgical procedure, and it typically becomes an established one after an intense inflammatory process with chronic pain and edema as the main symptoms. Available treatments for CRPS have low efficacy. This study aimed to evaluate the clinical and immunoregulatory effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on paw edema and anti- and pro-inflammatory cytokines and macrophage phenotypes in the chronic post-ischemia pain (CPIP) preclinical model of CRPS-Type I. Methods: Female Swiss mice were supplemented with omega-3, corn oil, or saline and then submitted to the CPIP model of ischemia/reperfusion (I/R) injury. Supplementation was carried out for 30 days prior to and up to 2 or 15 days after the induction of CPIP, according to experimental protocols. The supplementation protocol included 1,500 mg/kg of omega-3 or corn oil through an intragastric route (gavage). Paw edema, interleukin- (IL-) 4, IL-10, transforming growth factor-ß1 (TGF-ß1), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor (TNF) were then measured in the paw skin and muscle by enzyme-linked immunosorbent assay (ELISA), and macrophage phenotypes (M1 and M2) assessed in the paw muscle by Western blotting. Results: The CPIP model induced an increase in paw thickness up to 72 h post-I/R. Mice supplemented with omega-3 compared to the saline group displayed reduced edema but neither altered skin IL-4 or skin and muscle TGF-ß1, TNF, and MCP-1 concentrations, nor did they exhibit significantly altered muscle macrophage phenotype on the 2nd-day post-CPIP. However, omega-3 supplementation reversed the I/R-related reduction in IL-4 in the paw muscle compared to groups supplemented with saline and corn oil. Furthermore, omega-3 promoted the reduction of IL-10 levels in the paw skin, compared to animals with lesions supplemented with saline, until the 2nd-day post-CPIP. On the 15th day post-CPIP, IL-10 was significantly increased in the muscle of animals supplemented with omega-3 compared to the saline group. Conclusion: The results suggest that omega-3 PUFA supplementation has anti-inflammatory effects in the CPIP model of CRPS-Type I, significantly reducing paw edema and regulating concentrations of anti-inflammatory cytokines, including IL-4 and IL-10.

The role of spinal inhibitory neuroreceptors in the antihyperalgesic effect of warm water immersion therapy.

OBJECTIVE: Warm water immersion therapy (WWIT) has been widely used in the treatment of various clinical conditions, with analgesic and anti-inflammatory effects. However, its mechanism of action has not been fully investigated. The present study analyzed the role of spinal inhibitory neuroreceptors in the antihyperalgesic effect of WWIT in an experimental model of inflammatory pain. METHODS: Mice were injected with complete Freund's adjuvant (CFA; intraplantar [i.pl.]). Paw withdrawal frequency to mechanical stimuli (von Frey test) was used to determine: (1) the effect of intrathecal (i.t.) preadministration of naloxone (a non-selective opioid receptor antagonist; 5 µg/5 µl), (2); AM281 (a selective cannabinoid receptor type 1 [CB1] antagonist; 2 µg/5 µl), (3); and 1,3-dipropyl-8-cyclopentylxanthine (DPCPX; a selective adenosine A1 receptor antagonist; 10 nmol/5 µl), on the antihyperalgesic (pain-relieving) effect of WWIT against CFA-induced hyperalgesia. RESULTS: Intrathecal naloxone, AM281, and DPCPX significantly prevented the antihyperalgesic effect of WWIT. This study suggests the involvement of spinal (central) receptors in the antihyperalgesic effect of WWIT in a model of inflammatory pain. CONCLUSIONS: Taken together, these results suggest that opioid, CB1, and A1 spinal receptors might contribute to the pain-relieving effect of WWIT.

Lavandula angustifolia essential oil inhalation reduces mechanical hyperalgesia in a model of inflammatory and neuropathic pain: The involvement of opioid and cannabinoid receptors.

Lavandula angustifolia (LaEO) essential oil has been widely used by aromatherapy in the treatment of various clinical conditions, with evidence of its analgesic and anti-inflammatory potential. Our results demonstrate that sixty-five substances were identified in LaEO. Among the compounds found, the major ones were linalool (30.61%) and linalyl acetate (20.36%). We found that LaEO inhalation reduces mechanical hyperalgesia in conditions of chronic inflammatory and neuropathic pain. Furthermore, this effect seems to be mediated by peripheral and central opioid and cannabinoid 2 receptors. The findings of the present study suggests that the LaEO inhalation is effective on the chronic pain treatment.

Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial.

BACKGROUND: Venous ulcer represents the most advanced stage of chronic venous insufficiency. It is an important public health problem and has a significant impact on patients' quality of life due to chronic pain, inability to work, need for hospitalization and frequent outpatient follow-up. OBJECTIVE: We investigated the treatment benefits of far-infrared ceramic (cFIR), in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores, quality of life, serum bio-markers of oxidative stress and antioxidant defense enzymes. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul, Brazil. We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days. MAIN OUTCOME MEASURES: The following evaluations were conducted at baseline and after 15, 30, 60 and 90 days: ulcer healing score, quality of life, and serum markers of oxidative stress and antioxidant enzyme activity. RESULTS: Patients (n = 24) with lower limb venous ulcers were randomized into two treatment groups. cFIR decreased the ulcer size on day 30 (P = 0.042) and 90 (P = 0.034) and the total ulcer healing scale scores on day 30 (P = 0.049) and 90 (P = 0.02) of the treatment, when compared to baseline. Additionally, cFIR improved tissue type (epithelial tissue) on day 60 (P = 0.022) when compared to baseline evaluation. CONCLUSION: cFIR clinically improved ulcer healing in patients with lower limb venous ulcers. TRIAL REGISTRATION: RBR-8c7xzn on ReBEC.

Aquatic exercise and Far Infrared (FIR) modulates pain and blood cytokines in fibromyalgia patients: A double-blind, randomized, placebo-controlled pilot study.

Fibromyalgia (FM) has an inflammatory component, as elevated serum levels of inflammatory biomarkers are associated with its diagnosis. Treatments decreased pain, body temperature, improved quality of life and reduced serum levels of IL-6 in both groups; however, these beneficial effects were more pronounced in aquatic exercise (AE) + Far-Infrared (FIR) group. The findings of the present study suggest that the association of AE to FIR increases the benefits of aquatic exercise in patients with FM.

Study of transcranial therapy 904 nm in experimental model of stroke.

Cerebrovascular accidents (CVAs), commonly known as strokes, can damage the brain through vascular injuries caused by either blood vessel blockages (ischemic stroke) or ruptures (hemorrhagic stroke) which disrupt regular brain blood supply and can cause severe damage to the individual. The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device (904 nm, 110 mW, 7 J/cm2) on neurogenesis, muscle resistance, and motor behavior in animals submitted to an experimental model of hemiplegia. The sample consisted of 30 Wistar rats, divided into two groups: control group (GC) and 904-nm LED-treated group (TG). All animals underwent stereotactic surgery for electrode implant and subsequent electrolytic injury to induce an ischemic stroke. TG was subjected to daily LED irradiation (904 nm, 110 mW, 7 J/cm2) for 63 s. Suspension test results indicate an improvement of TG muscle resistance when compared with baseline evaluation (BLT); a reduction in open-field freezing time and the number of fecal bolus pellets suggest diminished anxiety induced by 904-nm LED treatment on treatment days 7 and 21 (TG7 and TG21) compared with the baseline results; and lastly, histological analysis showed important signs of neurogenesis in TG in comparison to CG, especially on treatment days 7 and 21 (TG7 and TG21). In conclusion, the present study suggests that 904-nm LED irradiation may beneficially affect neurogenesis, muscle resistance, and animal motor behavior following ischemic CVA.

Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol.

BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). Our exploratory analysis will evaluate the efficacy of the active LLLT on verbal and visuospatial episodic memory, executive functions (working memory, verbal and visuospatial fluency, attentional processes), and anxiety and depressive symptoms compared to the sham group. METHODS/DESIGN: A randomized double-blinded trial will be made in 36 patients with moderate and severe TBI. The active LLLT will use an optical device composed of LEDs emitting 632 nm of radiation at the site with full potency of 830 mW. The cranial region with an area of 400 cm2 will be irradiated for 30 min, giving a total dose per session of 3.74 J/cm2. The sham LLLT group contains only an LED device with power < 1 mW, only serving to simulate the irradiation. Each patient will be irradiated three times per week for six weeks, totaling 18 sessions. Neuropsychological assessments will be held one week before the beginning of the sessions, after one week, and three months after the end of LLLT sessions. Memory domain, attention, executive functioning, and visual construction will be evaluated, in addition to symptoms of depression, anxiety, and social demographics. DISCUSSION: LLLT has been demonstrated as a safe and effective technique in significantly improving the memory, attention, and mood performance in healthy and neurologic patients. We expect that our trial can complement previous finds, as an effective low-cost therapy to improve cognitive sequel after TBI. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02393079 . Registered on 20 February 2015.

Transcranial LED therapy on amyloid-ß toxin 25-35 in the hippocampal region of rats.

Excessive Aß deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer's disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) in the frontal region of the skull after being inoculated with the Aß toxin in the hippocampus; 30 rats were used as the control group (CG). The analysis was conducted at 7, 14, and 21 days after irradiation. We observed a decreased in Aß deposits in treated animals compared with animals in the CG. The behavioral and motor assessment revealed that the EG group covered a larger ground distance and explored the open field than the CG group on days 14 and 21 (p < 0.05). The EG group was statistically significant in the spatial memory test compared to the CG group on day 14. The use of PBM significantly reduced the presence of Aß plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.

Short-term changes in handgrip strength, body composition, and lymphedema induced by breast cancer surgery.

PURPOSE: This study investigated short-term changes in body composition, handgrip strength, and presence of lymphedema in women who underwent breast cancer surgery. METHODS: Ninety-five women participated in a cross-sectional study, divided into two groups: Control (n=46), with healthy women, and Experimental (n=49), with women six months after breast cancer surgery. The Experimental Group was subdivided into right total mastectomy (RTM, n=15), left total mastectomy (LTM, n=11), right quadrant (RQ, n=13), and left quadrant (LQ, n=10). It was also redistributed among women with presence (n=10) or absence (n=39) of lymphedema. Presence of lymphedema, handgrip strength, and body composition were assessed. RESULTS: Trunk lean mass and handgrip strength were decreased in the Experimental Group. Total lean mass was increased in the LTM compared to RTM or LQ. Left handgrip strength in LTM was decreased compared to RTM and RQ and in LQ compared to RTM and RQ. Finally, total lean mass, trunk fat mass, trunk lean mass, right and left arm lean mass were increased in women with lymphedema. CONCLUSIONS: Breast cancer survivors have changes in their body composition and in handgrip strength six months after surgery; however, the interaction between the type of surgery and its impact is unclear. Furthermore, women who developed lymphedema in this period showed more significant changes in the body composition, but they were not enough to cause impairment in handgrip strength.

Short-term changes in handgrip strength, body composition, and lymphedema induced by breast cancer surgery / Alterações a curto prazo na força de preensão palmar, composição corporal e linfedema induzido pela cirurgia do câncer de mama

PURPOSE: This study investigated short-term changes in body composition, handgrip strength, and presence of lymphedema in women who underwent breast cancer surgery. METHODS: Ninety-five women participated in a cross-sectional study, divided into two groups: Control (n=46), with healthy women, and Experimental (n=49), with women six months after breast cancer surgery . The Experimental Group was subdivided into right total mastectomy (RTM, n=15), left total mastectomy (LTM, n=11), right quadrant (RQ, n=13), and left quadrant (LQ, n=10). It was also redistributed among women with presence (n=10) or absence (n=39) of lymphedema. Presence of lymphedema, handgrip strength, and body composition were assessed. RESULTS: Trunk lean mass and handgrip strength were decreased in the Experimental Group. Total lean mass was increased in the LTM compared to RTM or LQ. Left handgrip strength in LTM was decreased compared to RTM and RQ and in LQ compared to RTM and RQ. Finally, total lean mass, trunk fat mass, trunk lean mass, right and left arm lean mass were increased in women with lymphedema. CONCLUSIONS: Breast cancer survivors have changes in their body composition and in handgrip strength six months after surgery; however, the interaction between the type of surgery and its impact is unclear. Furthermore, women who developed lymphedema in this period showed more significant changes in the body composition, but they were not enough to cause impairment in handgrip strength. .

OBJETIVO: Este estudo investigou alterações de curto prazo na composição corporal, na força de preensão palmar e na presença de linfedema em mulheres submetidas à cirurgia do câncer de mama. MÉTODOS: Noventa e cinco mulheres participaram de um estudo transversal, sendo divididas em dois grupos: Controle (n=46), mulheres saudáveis, e Experimental (n=49), mulheres seis meses após cirurgia do câncer de mama. O Grupo Experimental foi subdividido em mastectomia total direita (RTM, n=15), mastectomia total esquerda (LTM, n=11), quadrantectomia direita (RQ, n=13) e quadrantectomia esquerda (LQ, n=10). Também foi redistribuído entre mulheres com presença (n=10) ou ausência (n=39) de linfedema. Foram avaliadas a presença de linfedema, a força de preensão palmar e a composição corporal. RESULTADOS: A massa magra de tronco e a força de preensão palmar estavam diminuídas no Grupo Experimental. Massa magra total estava aumentada na LTM comparada à RTM ou LQ. Força de preensão palmar esquerda na LTM estava diminuída comparada à RTM e RQ e em LQ comparada à RTM e RQ. Finalmente, massa magra total, magra e gorda de tronco e massa magra de braço esquerdo e direito estavam aumentadas em mulheres com linfedema. CONCLUSÕES: Sobreviventes do câncer de mama possuem alterações na composição corporal e na força de preensão palmar seis meses após a cirurgia, porém a interação entre o tipo de cirurgia e seu impacto não está clara. Além disso, mulheres que desenvolveram linfedema neste período mostraram alterações mais significantes na composição corporal, mas que não foram suficientes para causar prejuízo na força de preensão palmar. .

Effect of posture-control insoles on function in children with cerebral palsy: randomized controlled clinical trial.

INTRODUCTION: Cerebral palsy (CP) is a posture and movement disorder and different therapeutic modalities, such as the use of braces, have sought to favor selective motor control and muscle coordination in such patients. The aim of the proposed study is to determine the effect of the combination of posture-control insoles and ankle-foot orthoses (AFOs) improving functional limitation in children with CP. METHODS/DESIGN: The sample will be composed of 24 children with CP between four and 12 years of age. After the signing of the statement of informed consent, the children will be randomly allocated to two groups: a control group using AFOs alone and an experimental group using both posture-control insoles and AFOs. Evaluations will be performed on five occasions: without any accessory (insoles or AFOs), immediately after, one month after, six months after and one year after AFOs or insole and AFOs use. The evaluation will involve the analysis of gait, static and functional balance, mobility and hypertonia. The three-dimensional assessment of gait will involve the eight-camera SMART-D SMART-D 140® system (BTS Engineering), two Kistler force plates (model 9286BA) and an eight-channel, wireless FREEEMG® electromyography (BTS Engineering). Static balance will be assessed using a Kistler force plate (model 9286BA). Clinical functional balance and mobility will be assessed using the Berg Balance Scale, Timed Up-and-Go Test and Six-Minute Walk Test. The posture-control insoles will be made of ethylene vinyl acetate, with thermal molding for fixation. The fixed orthoses will be made of polypropylene and attached to the ankle region (AFO). The results will be analyzed statistically, with the level significance set to 5% (p < 0.05). TRIAL REGISTRATION NUMBER: RBR6d342s (http://www.ensaiosclinicos.gov.br/news/).

Análise do equilíbrio estático em crianças com paralisia cerebral do tipo diparesia espástica com e sem o uso de órteses / Analysis of static balance in children with cerebral palsy spastic diparetic type with and without the use of orthoses

Introdução: Crianças com paralisia cerebral (PC) do tipo diparesia espástica são frequentes usuárias de órtesespara membros inferiores, com a finalidade de proporcionar melhora funcional da postura ortostática e durante a marcha. Objetivo: analisar o equilíbrio estático de crianças diparéticas espasticas com PC, com e sem uso de órteses, por meio de parâmetros estabilométricos. Materiais e métodos: A amostra foi composta por 15 indivíduos com idades entre 4 e 14 anos (médias de 8,33 ± 2,74), sete do sexo masculino e oito do sexo feminino, divididos em dois grupos: o grupo controle (GC) com seis participantes e o grupo estudado(GE) com nove crianças com PC diparesia espástica. Para a análise do equilíbrio estático utilizou-se uma plataforma de pressão (Medicapteurs Fusyo) e a coleta foi realizada com a criança em pé, em duas condições:com órteses e sem órteses. Resultados: O GE sem órtese apresentou maiores oscilações, estatisticamente significantes, no sentido médio-lateral e na área total de oscilação quando comparado ao desempenho do GC. Conclusão: Os resultados apresentados sugerem que a utilização de órteses para membros inferiores possa influenciar no equilíbrio estático, diminuindo a oscilação durante a postura ortostática estática

INTRODUCTION: Children with spastic diparetic cerebral palsy (CP) are frequent users of orthoses for lower limbs, in order to provide functional improvement of posture during walking and standing. OBJECTIVES: To analyze the static balance of spastic diparetic children with CP, with and without the use of orthoses, through stabilometric parameters. MATERIALS AND METHODS: The sample comprised 15 individuals aged between 4 and 14 years old (8.33 ± 2.74), seven males and eight females, divided into two groups: the control group (CG), with six participants, and the study group (SG), with nine spastic diparetic children with CP. For static balance analysis it was used a pressure platform (Medicapteurs Fusyo) and the collection was performed with the child standing on two conditions: with orthoses and without orthosis. RESULTS: The EG with orthesis showed higher oscilation, statistically significant, mediolateral and the total area of oscillation compared to the GC. CONCLUSION: The results suggest that the use of orthoses for lower limbs can influence the static balance, reducing the oscillation during static standing position.

Análise do equilíbrio em pacientes hemiparéticos após o treino com o programa Wii Fit / Balance analysis in hemiparetics patients after training with Wii Fit program

Objetivo: A hemiparesia é um comprometimento parcial do hemicorpo que altera o equilíbrio, sendo este essencialpara as atividades funcionais. Objetivo: Avaliar o equilíbrio em pacientes hemiparéticos submetidosao treino de equilíbrio com o programa Wii Fit, que atuou como um recurso de biofeedback visual. Método: Foram selecionados 12 pacientes hemiparéticos pós AVE, 5 do sexo masculino e 7 do sexo feminino, comidade média de 58 ± 12,57 anos, divididos aleatoriamente em dois grupos. Um deles realizou a fisioterapiaconvencional (GC) pelo período de uma hora, o outro realizou por trinta minutos e mais trinta minutos de treino de equilíbrio com auxílio do Wii Fit (GW), duas vezes por semana durante cinco semanas, completando dez sessões. O equilíbrio foi avaliado antes e após as intervenções, por meio da aplicação da Escala de Equilíbrio de Berg (EEB) e pela estabilometria, que mensura a oscilação do centro de pressão (COP),nos eixos ântero-posterior (AP) e médio-lateral (ML), por uma plataforma de pressão em duas condições: de olhos abertos (OA) e olhos fechados (OF). Resultados: De acordo com a EEB, os pacientes, tanto do GC quanto o do GW, obtiveram maior controle do equilíbrio estático e dinâmico. Na avaliação do COP no eixo ML, os indivíduos do GC e do GW tiveram diminuição na oscilação ML após a intervenção proposta para cada grupo, nas condições de OA e OF. No eixo AP do COP, o GC não teve diminuição na oscilação AP de OA e OF, eo GW apresentou diminuição na oscilação AP de OA e OF. Conclusão: O presente estudo demonstra que a fisioterapia associada ao treino de equilíbrio com o Wii Fit apresenta resultados significantes na reabilitaçãodos indivíduos hemiparéticos, obtendo, assim, mais um recurso terapêutico na fisioterapia.

Validação do teste de flexibilidade da coluna lombar proposto por Adrichem e Korst / Validalian of lumbar spine flexibility teses

Introdução: A flexibilidade é reconhecida como uma capacidade motora importante para a saúde, incluída nos testes de aptidão física e em exames clínicos. Avaliar a flexibilidade é essencial para se acompanhar seu desenvolvimento em programas de saúde e também nos exame clínicos. Objetivo: Esta pesquisa teve como objetivo verificar a fidedignidade e validade do teste de flexibilidade da coluna lombar de Adrichem e Korst. Método: Participaram do estudo 19 mulheres com média de idade 23,2±1,3 anos e 18 homens com média de idade 22,3±1,4 anos, universitários, aparentemente saudáveis e ativos. Resultados: Coeficiente de correlação intraclasse mostrou que a fidedignidade foi elevada para o sexo feminino e masculino, respectivamente (R==0,85) e (R==0,86). Em relação à validade o coeficiente de correlação de Pearson foi baixo para o sexo feminino (r== 0,24) e moderado para o sexo masculino (r== 0,50). Conclusão: Concluiu-se que o teste de flexibilidade da coluna lombar de Adrichem e Korst apresenta-se fidedigno, mas não pode ser considerado válido.

Introduction: Flexibility is known as an important motor capacity for health, included in physical tests and clinical evaluations. To evaluate flexibility is essential to accompany its development in health programs and also in clinical evaluations. Objective: The purpose of this study was to verify the reliability and validity of the flexibility test for the lumbar spine designed by Adrichem e Korst. Method: Nineteen women with a mean age of 23,2±1,3 years old and 18 men with a mean age of 22,3± 1A years old, healthy and active students participated in this study. Results: Intraclass correlation coeficient showed high reliability for woman and men, respectively (R==0.85) and (R==0.86). Pearson correlation coefficient was low for woman (r== 0.24) and moderate for men (r== 0.50). Conclusion: It was concluded that the flexibility test of the lumbar spine by Adrichem and Korst was reliable, but can not be considered valid.

Efeito da mobilização neural em sujeitos saudáveis / The effect of neural mobilization in upper limb to range of motion

Esta pesquisa teve por objetivo verificar a influência da mobilização do sistema nervoso utilizando o teste de tensão dos membros superiores (ULNT1), verificados mediante os testes de elevação da perna estendida (SLR) e de inclinação anterior (slump test) em adultos jovens. A pesquisa foi realizada em 26 indivíduos solicitando os testes de SLR e slump test antes e após mobilização do sistema nervoso e mensurado com um inclinômetro. Para a análise estatística, foi realizado o teste-T de Student, com nível de significância estatística de p<0,05. Quanto aos resultados o teste de SLR foi estatisticamente significante (p<0.003) com uma média antes da mobilização neural de 77º+-08 e após de 88º+-1,4 e o slump test apresentou uma média de 54,2º e pós-mobilização de 62,5+-2,1 após a mobilização neural respectivamente (p<0,006). Conclui-se, pelos testes de tensão neural SLR e o slump test que houve um aumento flexibilidade no membro inferior, após a realização da mobilização da mobilização neural ULNt1.

This research objectified to verify the influence of the mobilization of the nervous system being used the upper limb neural tension test (ULNT1), verified by means of straight leg raising test (SLR) and the slump test in young adults. The research was carried through in 26 individuals where the SLR test and the Slump test had been carried through before and after mobilization of the system nervous and measured by a digital inclinometer. For the statistic analysis, student's test-t was carried through, with the level of significance statistics of p<0,05. How much to the results the SLR test was statistically significant (p<0.003) with a average before the neural mobilization of 77º+-0,08 and after of 88º§-1,4 and slump test presented a average of 54,2º§-2,1 and after mobilizati mobilization of 62,5º after the neural mobilization respectively (p<0.006). It was concluded, by the tests of neural tension like SLR and slump test that it had an increase in the flexibility in the lower limb, after the accomplishment of neural mobilization ULNT1.

Estudo comparativo da atividade do sistema nervoso autônomo através da variabilidade da frequencia cardíaca em trabalhadores noturnos e diurnos / Comparartive study of the independent nervous system activity through the heart rate variability in nocturnal and diurnal workers

O estudo tem como objetivo comparar as alterações físicas entre os trabalhadores diurnos e noturnos. A alteração avaliada foi a variabilidade da frequência cardíaca através do Nerve Express. Também avaliamos a qualidade de vida dos indivíduos através de questionários respondidos antes dos testes. Mensuramos o quanto a ausência do sono noturno influencia na qualidade de vida das pessoas. Percebemos que os indivíduos trabalhadores do período noturno apresentaram melhores resultados quando avaliados em relação à variabilidade da frequência cardíaca, apesar de nos questionários demonstrarem uma maior insatisfação com a qualdiade do sono. Já quando questionados em relação à qualidade de vida ambos os grupos demonstram em sua maioria estarem satisfeitos. Acreditamos que os resultados possuem relação direta com o fato de não possuírem a presença direta de seus superiores.

The study has as objective to compare the physical alterations between the diurnal and nocturnal workers. the alteration evaluated ws the heart variability through nerve express. We also evaluated the quality of life of the individuals through questionnaires answered before the tests. We were able to measure how much the absence of nocturnal sleep influences in the quality of life of life of the people. We realized that the industrious individuals of the nocturnal period presented better results when evaluated regarding the heart variability, despite of in the questionnaires they showed a bigger dissatisfaction with the quality of the sleep. When they were questioned regarding the quality of life, both groups showed, in their majority is satisfied. We believe that the results have straight relation with the fact of the nocturnal workers work in a rhythm less accelerated than the diurnal one, by be not commercial schedule and of not have the straight presence of his superiors.

Análise da variabilidade da freqüência cardíaca após mobilização miofascial da região craniana / Analysis of hearth variability after myofascial mobilization on cranial region

Trata-se de uma pesquisa quantitativa, descritiva que tem como objetivo analisar o efeito de técnicas miofasciais, aplicadas na região craniana, no comportamento da variabilidade da freqüência cardíaca. Participaram do estudo 66 indivíduos (33 homens e 33 mulheres) voluntários e saudáveis, com idade variando de 20 a 30 anos. Utilizou-se o Nerve-Express, sistema completamente automático e não invasivo, que permite a avaliação da variabilidade da freqüência cardíaca. A avaliação foi realizada antes e após a aplicação das técnicas miofasciais na região craniana, executadas de acordo com os princípios da terapia craniossacral. As técnicas utilizadas foram: indução suboccipital; levantamente fronta; levantamento parietal; compressão-descompressão do esfenóide; sincronização e descompressão dos temporais. Os dados obtidos foram transportados para o banco de dados no programa Microsoft Excel 2007 e analisada pelo SPSS (versão 13.0). Foram considerados como estatisticamente significantes diferenças com p-valor <0.05. Após aplicação da técnica de mobilização miofascial, a freqüência cardíaca apresentou uma diminuição em ambos os grupos estudados. Pode-se observar neste estudo que a mobilização miofascial aplicada na região craniana provoca uma diminuição da freqüência cardíaca, ou seja, um aumento dos intervalos R-R.

Quantitative, descriptive research was conducted to analyze the effect of myofascial techniques, applied in the cranial region, on behavior of the heart rate variability. This study involves 66 healthy volunteers (33 men and 33 women) with age between 20 to 30 years. Nerve-Express was used to assessment heart rate variability; it is a fully automatic, non-invasive computer-based system. The evaluation was accomplished before and after the myofascial techniques application on the cranial region, they were executed in agreement with the beginnings of the craniosacral therapy. They ara them: suboccipital stimulation, frontal lift, parietal lift, sphenobasilar compression-decompression, temporal wobble and ear pull. The data were transported for a database in the Microsoft Excel 2007 program and analyzed by SPSS (version 13.0). The results were considered statistically significant when P<0.05. After application of the myofascial techniques, the heart rate presented a decrease in both studied groups. In this study can be observed that the myofascial mobilization applied in the skull region provokes a decrease of the heart rate, in other words, an increase of the intervals R-R.

Fortalecimento dos flexores dos dedos na fasceite plantar / Strenght musc1e flexors toe in plantar fasciitis

A fasceite plantar é comumente uma patologia vista por clínicos, ligados às diversas áreas incluindo a medicina desportiva, sendo um verdadeiro desafio aos tratamentos propostos.(1,9) A condição pode ser o resultado de estiramentos repetitivos da fáscia plantar, conduzindo para fadiga do tecido e microlesões, gerando inflamação e dor localizada. {2,4) A maioria dos autores concordam que as causas de fasceite plantar são numerosas e frequentemente multifatoriais; Fatores anatômicos, incluindo pés planos, pés cavos, desequilíbrio muscular, encurtamento de tríceps sural e discrepância de comprimento de MMIlss.{2,s,6,7,a,9)Outros fatores que podem contribuir são sapatos inadequados e desgastados, idade avançada, ganho de peso, uma variedade de doenças sistêmicas e sabrecargas mecânicas. (2,9,10,11)Dois fatores anatômicos implicados e contribuintes para a geração dos sintomas na fasceite plantar são a fraqueza muscular e o encurtamento da fáscia plantar (9,13,14). Através de avaliação regional e postural verificamos o déficit de força muscular e desequilíbrios na distribuição do peso corporal nos pés, foi realizado tratamento para readequação postural e específica dos músculos flexores plantares dos membros acometidos. Os pacientes com fasceite plantar obtiveram melhora do quadro álgico analisado através da escala análoga visual (EAV) inicial de media de 8,3 e final de média de 0,4 , deixaram de claudicar readquirindo a marcha normal após media de 4 a 6 sessões iniciais, acompanhados durante 30 dias do inicio do tratamento Fisioterapêutico.

Plantar fasciitis is a pathology commonly seen by clinicians, in some areas include sports Medicine, this is a challenge for the proposal treatments. The condition may result from repetitive stretching of the plantar fascia, leading fo the tissue and microtears, improved localized inflammation and pain. The most authors agree that the causes of plantar fasciitis are numerous and often multifactorial. Anatomic factors include pes plannus, pes cavus, muscles imbalance, triceps surae tightness and leg lengthdiscrepancies. Other factors include improper shoes fit and wear, increase age, weight gain, overtraining overuse and variety of systemic diseases. Two of the anatomic factors implicated as contributors to plantar fasciitis are muscle weakness and plantar fascia shortening. Physical regional and postural evaluation we verified deficits strength muscle flexors toe and imbalancein the distribution of weight-bearing in the feets, the treatment was made specific with the muscle flexors toe involved. The patients with fasciitis plantar improved strength and pain analised from inicial V.A.S 8.3 and finalV.A.S. 0,4, improved gait in four into six physiotherapy sessions , the average was the 30 days about the patients treated.