Comprehensive comparative analysis of the periodontal pathogen Porphyromonas gingivalis: exploring the pan-genome, the reconstruction of the gene regulatory network and genome-scale metabolic network.

Porphyromonas gingivalis is a nonmotile, obligate anaerobic, Gram-negative bacterium known for its association with periodontal disease and its involvement in systemic diseases such as atherosclerosis, cardiovascular disease, colon cancer, and Alzheimer's disease. This bacterium produces several virulence factors, including capsules, fimbriae, lipopolysaccharides, proteolytic enzymes, and hemagglutinins. A comparative genomic analysis revealed the open pangenome of P. gingivalis and identified complete type IV secretion systems in strain KCOM2805 and almost complete type VI secretion systems in strains KCOM2798 and ATCC49417, which is a new discovery as previous studies did not find the proteins involved in secretion systems IV and VI. Conservation of some virulence factors between different strains was observed, regardless of their genetic diversity and origin. In addition, we performed for the first time a reconstruction analysis of the gene regulatory network, identifying transcription factors and proteins involved in the regulatory mechanisms of bacterial pathogenesis. In particular, QseB regulates the expression of hemagglutinin and arginine deaminase, while Rex may suppress the release of gingipain through interactions with PorV and the formatum/nitrate transporter. Our study highlights the central role of conserved virulence factors and regulatory pathways, particularly QseB and Rex, in P. gingivalis and provides insights into potential therapeutic targets.

Maxillary sinus angiolymphoid hyperplasia with eosinophilia associated to orbital and cutaneous lesion.

INTRODUCTION: We describe the first case of ALHE in the orbit with extension to the maxillary sinus and the importance of a multidisciplinary approach to achieve removal of the lesion. CASE STUDY: A 72-year-old man presented with epiphora of the left eye and several episodes of recurrent acute dacryocystitis. Magnetic resonance imaging revealed a solid homogeneous mass located in the inferomedial region of the left orbit. In addition, it was associated with destruction of the adjacent ethmoidal wall and upper wall of the left maxillary sinus. Incisional biopsy of the orbital mass was compatible with ALHE. RESULTS: It was decided to perform surgery using an orbital floor approach, left medial wall via subconjunctival and caruncular approach together with an endoscopic nasal approach (ESS), achieving complete removal of the orbital mass and cleaning of the maxillary sinus. After one year of treatment, no tumor recurrence was evident through endoscopy and imaging tests and the patient is asymptomatic. CONCLUSIONS: ALHE is a very rare benign vascular tumor that presents subcutaneous nodules in the head and neck region. We do not know of any case of ALHE in the paranasal sinuses described in the literature, either in isolation or together with orbital or cutaneous ALHE. In conclusion, ALHE disease should be considered as a diagnosis when faced with an orbital mass with extension to the paranasal sinuses, and a complete excision through a combined endonasal and orbital approach prevents recurrence in most cases.

Vastus Lateralis Muscle Flap for High-Risk Patients Undergoing Orthopaedic Hip Surgery.

INTRODUCTION: Chronic infections and soft-tissue defects are serious complications after total hip arthroplasties (THAs) that may require hip disarticulation (HD). HD is a relatively high-risk procedure with poor long-term outcomes and survival. This is the first study to analyze the effect of an ipsilateral, pedicled vastus lateralis (VL) muscle flap in preventing HD in patients with recurrent complications after THA. METHODS: This retrospective case review analyzed the 6-month postoperative outcomes of 14 patients who underwent soft-tissue hip reconstruction with a VL muscle flap by a single surgeon. RESULTS: Most (86%) patients fully recovered after 6 months with preserved hip range of motion, no pain, and no weakness on ambulation. Two (14%) patients ultimately required HD despite introducing a VL flap. DISCUSSION: A VL muscle flap is an effective treatment of nonhealing THA and prophylactic intervention for patients at high risk for HD. The VL muscle is optimal because of its large size allowing reduction of soft-tissue dead space, its local anatomical location to the hip, and its exceptional vascularity. Additional prospective studies are necessary to determine the most appropriate population for this technique.

Relación del apoyo social percibido y el logro de las metas de compensación de los pacientes con hipertensión arterial y diabetes mellitus / Relationship of perceived social support and the compensation goals of patients with arterial hypertension and diabetes mellitus

INTRODUCCIÓN: Las enfermedades crónicas son un problema actual que presentan altos porcentajes de descompensación en pacientes hipertensos y diabéticos, que hace interesante evaluar los determinantes sociales que influyen en la situación, como el apoyo social. OBJETIVO DEL ESTUDIO: fue relacionar el apoyo social percibido, adherencia a medicamentos, literacidad y variables sociodemográficas con el logro de compensación en pacientes con hipertensión arterial y diabetes mellitus. METODOLOGÍA: De tipo descriptivo correlacional de corte transversal. RESULTADOS: Se estudió a 600 personas, con un promedio de edad de 62,9 años, 63,5% mujeres. Un 64,66% son diabéticos y 89,5% hipertensos (46,9% y 43,33% descompensados respectivamente). El apoyo social percibido fue alto y presentan una inadecuada adherencia al tratamiento farmacológico y una adecuada literacidad en salud (57,6%). Se realiza un análisis de relaciones que demuestran relación significativa entre una menor percepción de apoyo instrumental y ser mujer; la percepción del apoyo de interacción social disminuye con el aumento de la edad y en relación con el apoyo afectivo, disminuye la percepción a mayores años de estudios. Al realizar una regresión logística, entre la percepción de apoyo social baja y los niveles de compensación de los parámetros de compensación no se evidencia una relación estadísticamente significativa. Se evidencia una asociación entre las personas con menos de 8 años de estudio y presentar presiones arteriales elevadas. DISCUSIÓN: Existe dificultad en la medición del concepto de apoyo social, dado que el sentido y significancia es personal. Las patologías crónicas como estresores debe ser un elemento que continúe estudiándose con estudios longitudinales y experimentales. Las estrategias clínicas para la compensación de la hipertensión y la diabetes deben ir más allá del apoyo social, considerando las crecientes complicaciones y proyecciones de mortalidad. CONCLUSIÓN: Se destaca la importancia de abordar el apoyo social considerando su naturaleza subjetiva y contextual, aunque no se estableció una correlación directa con el logro terapéutico. Se señala la inadecuada adherencia al tratamiento farmacológico, la asociación entre baja escolaridad y presiones arteriales elevadas.

INTRODUCTION: Chronic diseases are a current problem since there are high percentages of decompensation in hypertensive and diabetic patients, which makes it interesting to evaluate the social determinants that influence and social support as a multidimensional concept. OBJECTIVE: To relate the perceived social support, medication adherence, literacy and sociodemographic variables with the achievement of compensation in patients with arterial hypertension and / or diabetes mellitus. METHODOLOGY: Descriptive correlational descriptive study is performed methodologically. RESULTS: 600 people were studied, with an average age of 62.9 years, 63.5% women. 64.66% are diabetic and 89.5% hypertensive (46.9% and 43.33% decompensated respectively). The perceived social support was high and showed inadequate adherence to drug treatment and adequate literacy (57.6%). An analysis of relationships that are significantly related between a lower perception of instrumental support and being a woman is performed; the perception of social interaction support with increasing age and in relation to affective support, the perception of older years of studies. When performing a logistic regression, there is no statistically significant relationship between the perception of low social support and the compensation levels of the compensation parameters. There is evidence of an association between children under 8 years of study and presentation of high arterial references. DISCUSSION: There is difficulty in measuring the concept of social support, since the meaning and meaning is personal. Chronic pathologies as stressors should be an element that continues to study with longitudinal and experimental studies. Clinical strategies for the compensation of hypertension and diabetes must go beyond social support, considering the increasing complications and mortality projections. CONCLUSION: Emphasizes the importance of addressing social support considering its subjective and contextual nature, though no direct correlation with therapeutic achievement was established. Highlights inadequate adherence to pharmacological treatment, the association between low education and elevated blood pressure.

Efeitos de um protocolo de aquecimento-alongamento-resfriamento sobre a flexibilidade muscular / Effects of a warm-up-cool-down protocol on muscle flexibility

Objetivo: Investigar os efeitos da associação entre alongamento e recursos termoterapêuticos sobre o ganho de flexibilidade e amplitude de movimento. Métodos: Este ensaio clínico, controlado, não randomizado e cego teve duração de três semanas, com duas sessões semanais e incluiu 27 indivíduos do sexo feminino, as quais compuseram tanto o grupo experimental quanto o controle, de forma que um de seus membros inferiores recebeu a intervenção terapêutica dos recursos termoterapêuticos e o membro oposto foi submetido apenas ao alongamento. A análise angular foi realizada através do software de avaliação postural Kinovera. Resultados: Os efeitos do alongamento associado ao calor prévio e resfriamento pós intervenção se mostraram mais eficazes comparado ao grupo controle pré-intervenção (p<0,000), grupo controle pós intervenção (p= 0,003) e grupo experimental pré-intervenção (p<0,000). Conclusão: A aplicação de calor prévio ao alongamento, seguido pelo emprego imediato de resfriamento propicia ganhos de flexibilidade muscular e amplitude de movimento maiores que o alongamento simples.

Objective: To investigate the effects between stretching and thermotherapeutics resources on gaining flexibility and range of motion. Methods: This controlled, non- randomized, blinded clinical trial lasted three weeks, with two weekly sessions and included 27 female individuals, who made up both the experimental and the control group, so one of their legs received therapeutic intervention from chemotherapeutic resources and the opposite one was submitted to stretching only. Angular analysis was performed using the Kinovera postural assessment software. Results: The effects of stretching associated with pre-intervention heat and post-intervention cooling were more effective compared to the pre-intervention control group (p<0.000), post- intervention control group (p= 0.003) and pre-intervention experimental group (p<0.000). Conclusion: The application of heat prior to stretching followed by immediate cooling provides gains in muscle flexibility and range of motion greater than simple stretching.

Metagenomic analysis and antimicrobial activity of two fermented milk kefir samples.

In recent years, the fermented milk product kefir has been intensively studied because of its health benefits. Here, we evaluated the microbial consortia of two kefir samples, from Escarcega, Campeche, and Campeche (México). We considered a functional comparison between both samples, including fungal and bacterial inhibition; second, we applied shotgun metagenomics to assess the structure and functional diversity of the communities of microorganisms. These two samples exhibited antagonisms against bacterial and fungal pathogens. Bioactive polyketides and nonribosomal peptides were identified by LC-HRMS analysis. We also observed a high bacterial diversity and an abundance of Actinobacteria in both kefir samples, and a greater abundance of Saccharomyces species in kefir of Escarcega than in the Campeche kefir. When the prophage compositions were evaluated, the Campeche sample showed a higher diversity of prophage sequences. In Escarcega, we observed a prevalence of prophage families that infect Enterobacteria and Lactobacillus. The sequences associated with secondary metabolites, such as plipastatin, fengycin, and bacillaene, and also bacteriocins like helveticin and zoocin, were also found in different proportions, with greater diversity in the Escarcega sample. The analyses described in this work open the opportunity to understand the microbial diversity in kefir samples from two distant localities.

Bariatric surgery in Mexico: training, practice and surgical trends.

Bariatric surgery is extremely safe and effective, but several factors need to be addressed to obtain such results. Patient selection, type of training, accreditation, type of practice, and surgical trends and technique are involved in this process. Local and global standardization are ill-advised, especially in countries with high obesity prevalence, and where the bariatric practice is fast growing.An online survey with 22 questions was sent to bariatric surgeons in Mexico. Only participants with the active practice were included, and the aim was to obtain for the first time insight in bariatric surgery training, characteristics of current practice and surgical trends.Complete responses from 114 surgeons were obtained. Most were male, under 50 years-old, ≤ 10 years of experience, and practice in low-volume hospitals. Less than half had a 12-month formal training. Gastric bypass and sleeve gastrectomy were the most common procedures. Practice trends like leak tests, use of drains, preoperative weight loss, routine endoscopy, and pharmacological tromboprofilaxis are common. In surgical technique, the gastric bypass and sleeve gastrectomy confection was more homogenic when compared to the one-anastomosis gastric bypass.Complete responses from 114 surgeons were obtained. Most were male, under 50 years-old, ≤ 10 years of experience, and practice in low-volume hospitals. Less than half had a 12-month formal training. Gastric bypass and sleeve gastrectomy were the most common procedures. Practice trends like leak tests, use of drains, preoperative weight loss, routine endoscopy, and pharmacological tromboprofilaxis are common. In surgical technique, the gastric bypass and sleeve gastrectomy confection was more homogenic when compared to the one-anastomosis gastric bypass. An important number of bariatric surgeons in Mexico are young, male, and with < 10 years of practice. The most common techniques performed are gastric bypass and sleeve gastrectomy. Several practices and technique trends are similar to global consensus. Fellowship programs and Board Certification in bariatric surgery are major advances in our country, thus standardization and high-quality practice can be achieved.

Quality of life and the work capacity of professional nursing staff in the hospital environment

This study aimed to evaluate the association between life quality and the work capacity of nursing professionals in a public hospital of the public health system. A cross-sectional, quantitative study with the participation of 115 nursing professionals. The study method used the WHOQOL-brief questionnaire, the Work Capacity Index questionnaire, and a sociodemographic and occupational questionnaire. The data were analyzed through descriptive and inferential statistics, where values of p≤ 0.05 were considered significant. In terms of life quality, the domains that presented higher averages were for psychological 70.0±14.5 and social relations 70.8±19.8, with the physical domain reaching 64.4±11.9 and the environment at 57.7±13.6. The average score from the Work Capacity Index was 40.3±6.1; median: 42; IQR: 37.0-45.0), with a predominance of good and excellent for work capacity. Work capacity was increased for being male (ß=3.99; p=0.016) and negatively associated to age (ß=-0.31; p<0.001). In conclusion, it is verified that there is a positive correlation between the capacity for work and the evaluation of the quality of life, but it is emphasized that the sociodemographic and occupational characteristics lead the nursing professional to present a work capacity reduction, which generates alterations in the perception of life quality.

Impacto de la pandemia por SARS-CoV-2 en adolescentes que viven con el VIH en Lima, Perú / Impact of SARS-CoV-2 pandemic on adolescents living with HIV in Lima, Peru

RESUMEN Los adolescentes que viven con el VIH (AVVIH) tienen tasas más bajas de supresión virológica y tasas más altas de deterioro inmunológico en comparación con sus contrapartes mayores, colocándolos potencialmente en alto riesgo de enfermedad severa por SARS-CoV-2. Los AVVIH que están transicionando hacia el cuidado de adultos enfrentan dificultades adicionales para permanecer en el cuidado y adherirse al tratamiento antirretroviral. En esta sección especial reportamos el impacto observado en AVVIH transicionando al servicio de VIH para adultos durante la pandemia por SARS-CoV-2. En primer lugar, el acceso a la atención del VIH se ha visto perjudicado por la restricción del transporte público, la falta de antirretrovirales, y la suspensión de citas médicas y laboratoriales. Adicionalmente, dificultades financieras, incertidumbre sobre el futuro, estresores emocionales, alteración del estilo de vida y el temor de divulgar el diagnóstico involuntariamente han desafiado aún más la continuidad en la atención de esta población adolescente.

ABSTRACT Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine medical and laboratory appointments. In addition, financial hardship, uncertainty about their future plans, emotional stressors, lifestyle disruptions, and concerns of involuntary disclosure have further challenged continuity in care for this adolescent population.

Impacto de la pandemia por SARS-CoV-2 en adolescentes que viven con el VIH en Lima, Perú / Impact of SARS-CoV-2 pandemic on adolescents living with HIV in Lima, Peru

RESUMEN Los adolescentes que viven con el VIH (AVVIH) tienen tasas más bajas de supresión virológica y tasas más altas de deterioro inmunológico en comparación con sus contrapartes mayores, colocándolos potencialmente en alto riesgo de enfermedad severa por SARS-CoV-2. Los AVVIH que están transicionando hacia el cuidado de adultos enfrentan dificultades adicionales para permanecer en el cuidado y adherirse al tratamiento antirretroviral. En esta sección especial reportamos el impacto observado en AVVIH transicionando al servicio de VIH para adultos durante la pandemia por SARS-CoV-2. En primer lugar, el acceso a la atención del VIH se ha visto perjudicado por la restricción del transporte público, la falta de antirretrovirales, y la suspensión de citas médicas y laboratoriales. Adicionalmente, dificultades financieras, incertidumbre sobre el futuro, estresores emocionales, alteración del estilo de vida y el temor de divulgar el diagnóstico involuntariamente han desafiado aún más la continuidad en la atención de esta población adolescente.

ABSTRACT Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine medical and laboratory appointments. In addition, financial hardship, uncertainty about their future plans, emotional stressors, lifestyle disruptions, and concerns of involuntary disclosure have further challenged continuity in care for this adolescent population.

Enfermedad Celíaca en el adulto. Un reto en el nuevo milenio / Celiac disease in adulto. A challenge in the new millennium / Doença celíaca em adultos. Um desafio no novo milênio

RESUMEN La enfermedad celíaca una afección autoinmune producida por intolerancia alimentaria permanente al gluten y prolaminas con carácter genético. Uno de los problemas de esta enfermedad en el adulto es el infra diagnóstico, ya que por cada caso diagnosticado hay un promedio de cinco casos sin diagnosticar, debido a la sintomatología atípica, mínima, o incluso ausente. Por ello se realiza una revisión del tema con el objetivo de describir la enfermedad celíaca en el adulto y proporcionar elementos para su diagnóstico en pacientes con síntomas sugestivos. Para la obtención de la información se efectuó una búsqueda en bases de datos bibliográficas de literatura científica de la BVS de Cuba como PubMed/Medline y Lilacs. También se consultaron algunas fuentes de información disponibles a texto completo como Clinical Key, Cochrane Library, Ebsco y SciELO Cuba. Se realizó además una búsqueda en internet de portales de instituciones de reconocido prestigio en el ámbito sanitario como la World Gastroenterology Organisation, Instituto Nacional de Gastroenterología de Cuba, documentos oficiales de la Organización Mundial de la Salud, entre otras y se llegó a la conclusión quela Enfermedad Celíaca requiere un alto índice de sospecha clínica, el diagnóstico debe basarse en la presencia de alguno o varios síntomas relacionados con la afectación intestinal o de cualquiera de los órganos o sistemas asociados, en Cubano existen datos epidemiológicos de la enfermedad en adultos, por lo que es necesario la implementación de un protocolo para el diagnóstico de estos pacientes, pues el retraso o ausencia en el diagnóstico tiene consecuencias para la salud del individuo.

ABSTRACT Celiac disease is an autoimmune condition caused by permanent food intolerance to gluten and genetic prolamins. One of the problems of this disease in the adult is the infra diagnosis, since for each case diagnosed there is an average of five cases without diagnosis, due to the atypical, minimal, or even absent symptomatology. Therefore, a review of the subject is carried out with the objective of describing celiac disease in adults and providing elements for diagnosis in patients with suggestive symptoms. To obtain the information, a search was made in bibliographic databases of scientific literature of the VHL of Cuba as PubMed / Medline and Lilacs. Some sources of information available in full text such as Clinical Key, Cochrane Library, Ebsco and SciELO Cuba were also consulted. An internet search was also carried out on portals of institutions of recognized prestige in the healthcare field such as the World Gastroenterolog and Organization, National Institute of Gastroenterology of Cuba, official documents of the World Health Organization, among others and the conclusion was reached that Celiac Disease requires a high index of clinical suspicion, The diagnosis must be based on the presence of any or several symptoms related to intestinal involvement or any of the associated organs or systems, in Cuba there are epidemiological data of the disease in adults, so it is necessary to implement a protocol for the diagnosis of these patients, because the delay or absence in the diagnosis has consequences for the health of the individual.

RESUMO A doença celíaca é uma condição auto-imune causada pela intolerância alimentar permanente ao glúten e prolaminas com caráter genético. Um dos problemas desta doença em adultos é o subdiagnóstico, pois para cada caso diagnosticado há uma média de cinco casos não diagnosticados, devido a sintomas atípicos, mínimos ou até ausentes. Por esse motivo, é realizada uma revisão do assunto com o objetivo de descrever a doença celíaca em adultos e fornecer elementos para seu diagnóstico em pacientes com sintomas sugestivos. Para obter as informações, foi realizada uma busca em bancos de dados bibliográficos da literatura científica da BVS de Cuba, como PubMed / Medline e Lilacs. Algumas fontes de informações em texto completo também foram consultadas, como Clinical Key, Cochrane Library, Ebsco e SciELO Cuba. Também foi realizada uma busca na Internet por portais de instituições de reconhecido prestígio no campo da saúde, como a Organização e Gastroenterologia Mundial, o Instituto Nacional de Gastroenterologia de Cuba, documentos oficiais da Organização Mundial da Saúde, entre outros, e foi concluído A doença celíaca requer um alto índice de suspeita clínica, o diagnóstico deve ser baseado na presença de um ou mais sintomas relacionados ao envolvimento intestinal ou a qualquer um dos órgãos ou sistemas associados; em Cuba, existem dados epidemiológicos da doença em adultos, motivo pelo qual é necessária a implementação de um protocolo para o diagnóstico desses pacientes, uma vez que o atraso ou ausência no diagnóstico tem consequências para a saúde do indivíduo.

Aplicación del aceite de girasol ozonizado en pacientes afectados con gingivitis crónica fibroedematosa / Application of ozonated sunflower oil in patients affected with chronic fibroedematous gingivitis / Aplicação de óleo de girassol ozonizado em pacientes afetados com gengivite fibroedematosa crônica

RESUMEN Se realizó un estudio cuasi experimental de intervención terapéutica con el objetivo de evaluar la respuesta a la aplicación del Oleozón como tratamiento único en pacientes diagnosticados con gingivitis crónica fibroedematosa, que acudieron a consulta de la clínica estomatológica Docente Manuel Sánchez Silveira de Manzanillo, en el período de septiembre 2016 a mayo 2017. El universo de estudio lo constituyeron 102 pacientes afectados con esta entidad. Se registraron las variables edad, sexo, higiene bucal, frecuencia de la aplicación del tratamiento, respuesta a la terapia. El diagnóstico confirmado de gingivitis crónica fibroedematosa se realizó a partir de la clínica y el examen físico oral de la encía marginal y papilar. Se empleó una metodología para la aplicación en las regiones afectadas del preparado medicinal, se evaluó a cada paciente al 3er, 7mo y 15 días en las categorías igual, mejorado y curado. Predominó el grupo de edad de 20 a 29 años y el sexo masculino. Resaltaron los índices inadecuados de higiene bucal. La mejor respuesta al tratamiento fue entre 7 y 15 día demostrando que el Oleozón es efectivo en el tratamiento de la gingivitis crónica edematosa.

ABSTRACT A quasi-experimental therapeutic intervention study was carried out with the objective of evaluating the response to the application of Oleozón as the only treatment in patients diagnosed with chronic fibroedematous gingivitis, who came to the consultation of the Manuel Sánchez Silveira de Manzanillo Teaching Clinic, in the period from September 2016 to May 2017. The study universe consisted of 102 patients affected with this entity. The variables age, sex, oral hygiene, frequency of treatment application, response to therapy were recorded. The confirmed diagnosis of chronic fibroedematous gingivitis was made from the clinic and the oral physical examination of the marginal and papillary gums. A methodology for the application in the affected regions of the medicinal preparation was used, each patient was evaluated on the 3rd, 7th and 15 days in the equal, improved and cured categories. The age group of 20 to 29 years and the male sex predominated. They highlighted the inadequate rates of oral hygiene. The best response to treatment was between 7 and 15 days, demonstrating that Oleozon is effective in the treatment of chronic edematous gingivitis.

RESUMO Foi realizado umestudo de intervenção terapêutica quase experimental, como objetivo de avaliar a resposta à aplicação de Oleozón como único tratamento em pacientes com diagnóstico de gengivite fibroedematosa crônica, consultados na Clínica Manuel Sánchez Silveira de Manzanillo, no período de setembro de 2016 a maio de 2017. O universo do estudo foi composto por 102 pacientes acometidos por essa entidade. As variáveis ​​idade, sexo, higiene bucal, frequência de aplicação do tratamento e resposta à terapia foram registradas. O diagnóstico confirmado de gengivite fibroedematosa crônicafoi realizado na clínica e no exame físico oral das gengivas marginal e papilar. Foi aplicada uma metodologia para a aplicação nas regiões afetadas da preparação medicinal, cada paciente foi avaliado no 3º, 7º e 15 dias nas categorias igual, melhorada e curada. A faixa etária de 20 a 29 anos e o sexo masculino predominaram. Eles destacaram as taxas inadequadas de higiene bucal. A melhor resposta ao tratamento foi entre 7 e 15 dias, demonstrando que o Oleozon é eficaz no tratamento da gengivite edematosa crônica.

Sex-on-premise venues, associated risk behaviors, and attitudes toward venue-based HIV testing among men who have sex with men in Lima, Perú.

BACKGROUND: In Perú, HIV disproportionately affects men who have sex with men (MSM). Despite widespread access to treatment, the high rate of new HIV infections has remained unchanged over the last decade. Low knowledge of HIV status associated with late diagnosis is a key factor underlying the high HIV incidence observed in this setting, creating conditions for efficient onward transmission. Improving access to HIV testing and prevention services for those at highest risk is an important public health priority. Sex-on-premise venues (SOPVs) - saunas, sex clubs, pornographic movie theaters, hourly hotels, and bars/discos with areas where sex is permitted - may be opportune sites for outreach; however, further research on SOPVs and the populations who frequent them is needed to inform such efforts. METHODS: We conducted a cross-sectional online survey of adult MSM in Lima, Perú to evaluate patterns of SOPV attendance, associated sexual risk behaviors, and attitudes toward SOPV-based interventions. Participants were recruited through outreach to social media networks affiliated with local LGBTQ-aligned community groups. Our primary analytic objective was to estimate the association of HIV-related sexual risk behaviors and SOPV attendance. Additionally, we performed exploratory analyses to describe risk behavior stratified by SOPV category and to examine the relationship between SOPV attendance and the use of online platforms to meet sex partners. RESULTS: Overall, 389 MSM completed the survey from November 2018 through May 2019, of whom 68% reported attending an SOPV in the last 3 months. SOPV attendance was associated with multiple sexual risk behaviors, including transactional sex, group sex, substance use around the time of sex, and higher number of partners. Over two thirds of SOPV attendees indicated they would accept HIV testing if offered at SOPVs. CONCLUSIONS: SOPV attendance was common among MSM in Lima who participated in our survey, and SOPV attendees reported significantly greater engagement in sexual risk behaviors related to HIV transmission. Attitudes toward hypothetical SOPV-based interventions were generally favorable. These findings suggest that outreach at SOPVs may be an effective mechanism for reaching a particularly high-risk sub-population of MSM in Perú to deliver targeted HIV testing and prevention interventions.

Valor pronóstico de la hemoglobina glicada HbA1c en el padecimiento de retinopatía diabética en pacientes con diabetes mellitus tipo II / Prognostic value of glycated hemoglobin HbA1c in diabetic retinopathy in patients with type II diabetes mellitus / Valor prognóstico da hemoglobina glicada HbA1c na retinopatia diabética em pacientes com diabetes mellitus tipo II

RESUMEN Se realizó un estudio analítico transversal, con el objetivo de establecer el valor pronóstico de la hemoglobina glicada en la aparición de la retinopatía diabética en la Policlínica Universitaria Ángel Ortiz Vázquez. 2015-2019.El universo estuvo constituido por 181 pacientes con diagnóstico de diabetes mellitus tipo II, cada paciente fue seguido por dos años realizándose tres hemoglobinas glicada, tres glicemias en ayuna y dos controles oftalmológicos. Se observó una relación incremental del riesgo de retinopatía diabética según el nivel de hemoglobina glicada ascendente fundamentada en el incremento en la tendencia del riesgo asociado para retinopatía diabética, desde casi el doble (OR=1.89) con cifras de HbA1c entre 7.1 y 8.0 hasta más del triple (OR=3.51) cuando los valores de HbA1c fueron iguales o mayores a 10.1. La presencia de retinopatía diabética está en relación con los niveles de hemoglobina glicada, hecho que responde a un control glucémico inapropiado sostenido, que además promueve la aparición de otras complicaciones crónicas de la enfermedad.

ABSTRACT A cross-sectional analytical study was carried out, with the objective of establishing the prognostic value of glycated hemoglobin in the appearance of diabetic retinopathy at the Ángel Ortiz Vázquez University Polyclinic. 2015-2019. The universe was made up of 181 patients diagnosed with type II diabetes mellitus, each patient was followed for two years with three glycated hemoglobins, three fasting glycemia and two ophthalmological controls. An incremental relationship of the risk of diabetic retinopathy was observed according to the level of ascending glycated hemoglobin based on the increase in the trend of the associated risk for diabetic retinopathy, from almost double (OR = 1.89) with HbA1c figures between 7.1 and 8.0 to more. triple (OR = 3.51) when HbA1c values ​​were equal to or greater than 10.1. The presence of diabetic retinopathy is related to the levels of glycated hemoglobin, a fact that responds to sustained inappropriate glycemic control, which also promotes the appearance of other chronic complications of the disease.

RESUMO Foi realizado um estudo analítico transversal, com o objetivo de estabelecer o valor prognóstico da hemoglobina glicada no aparecimento de retinopatia diabética na Policlínica da Universidade Ángel Ortiz Vázquez. 2015-2019. O universo foi constituído por 181 pacientes com diagnóstico de diabetes mellitus tipo II; cada paciente foi acompanhado por dois anos com três hemoglobinas glicadas, três glicemia de jejum e dois controles oftalmológicos. Foi observada uma relação incremental do risco de retinopatia diabética de acordo com o nível de hemoglobina glicada ascendente, com base no aumento da tendência do risco associado à retinopatia diabética, de quase o dobro (OR = 1,89) com valores de HbA1c entre 7,1 e 8,0 para mais. triplo (OR = 3,51 quando os valores de HbA1c forem iguais ou superiores a 10,1. A presença de retinopatia diabética está relacionada aos níveis de hemoglobina glicada, fato que responde ao controle glicêmico inadequado sustentado, que também promove o aparecimento de outras complicações crônicas da doença.

OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador.

Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.

Estudo da associação entre os dados antropométricos e articulares com a dor em praticantes de balé clássico / Study of the association between anthropometric and articular data with pain in classical ballet practice

Objetivo: o estudo tem como objetivo, estudar os fatores musculoesqueléticos que podem gerar dor em bailarinas clássicas. Os movimentos do balé requerem que o desempenho seja realizado com maestria, envolvendo posições articulares em seu limite e esforços musculares que podem exceder as amplitudes normais de movimento, gerando assim, elevado estresse mecânico nos ossos e tecidos moles. Diversos fatores podem estar associados a dores intensas e a lesões musculoesqueléticas em praticantes de balé clássico. Materiais e métodos: foi realizado um estudo de caso, no qual foram avaliados os dados de três bailarinas clássicas com idade entre 15 e 17 anos, em um estúdio de balé clássico selecionado e localizado no interior de Goiás. Para coleta de dados foram utilizados dois instrumentos, sendo eles o Questionário de Avaliação da Bailarina Clássica, formulado pela própria pesquisadora e a avaliação física, onde foram coletados dados a partir de uma ficha elaborada pelos pesquisadores. Resultados: as voluntárias referiram dor, principalmente no movimento de grand plié, aumento da amplitude de abdução de quadril e fraqueza nos rotadores laterais de quadril. Conclusão: este estudo revelou uma maior incidência de episódios de dor em bailarinos clássicos causada por desequilíbrio de força muscular em membros inferiores..(AU)

Objective: this study aims to study the musculoskeletal factors that can generate pain in classical dancers. There are several types of dance and classic ballet stands out among them, because it is common to find dancers with various injuries due to physical exertion, because their practitioners suffer high mechanical stress their musculoskeletal structures. Several factors may be associated with intense pain and musculoskeletal injuries in classical ballet practitioners. Materials and methods: a case study was carried out, in which the data of three classical ballet dancers aged 15 to 17 years old were evaluated in a classical ballet studio selected and located in the interior of Goias. Two instruments were used to collect data, The Classical Dancer Evaluation Questionnaire, formulated by the researcher herself and the physical evaluation, where data were collected from a file prepared by the researchers. Results: the volunteers referred pain mainly to the large movement, with increased abduction hip range of motion and weakness in the lateral hip rotators. Conclusion: this study revealed a higher incidence of pain episodes in classical dancers caused by imbalance of muscle strength in the lower limbs..(AU)

Correlação entre os níveis de independência, nutrição, provas de forças de músculos ventilatórios e equilíbrio em idosos / Correlation amongdegrees of independence, mutrition, ventilatory muscles streng tests and equilibrium in olde adults

Introdução: O processo de envelhecimento proporciona alterações funcionais, psicossociais e biológicas de caráter progressivo e irreversível, diminuindo a capacidade funcional e pulmonar dos idosos. A fraqueza muscular presente nos idosos pode reduzir o nível de atividades funcionais e do sistema respiratório, favorecendo a inatividade e dependência. Objetivo: Avaliar a correlação entre a capacidade funcional e pulmonar em idosos. Metodologia: Estudo descritivo transversal, no qual foi realizada uma avaliação por meio do Índice de Barthel Modificado, da PI máx, PE máx com a utilização de manuvacuometro, da circunferência da panturrilha (CP) e do teste Timed Up and Go (TUG). A amostra foi de 40 idosos. Resultados: a associação significativa entre achados de força da musculatura inspiratória, CP, teste TUG, Índice de Barthel, PI máx, PE máx e idade, correlaciona a redução da força muscular com menor nível de capacidade funcional em idosos, ainda mais significativa no sexo masculino, com menor tempo para a realização do teste TUG, comparado ao sexo feminino. Conclusão: Houve correlação entre o nível de capacidade funcional e pulmonar de idosos, demonstrando a importância da associação do treinamento da função respiratória associado ao exercício físico.(AU)

Introduction: The aging process provides functional, psychosocial and biological changes of a progressive and irreversible character, reducing the functional and pulmonary capacity of older adults. The muscular weakness present in older persons reduces the level of functional activities and the respiratory system, favoring inactivity and dependence. Objective: Evaluate the correlation between functional and pulmonary capacity in older people. Methodology: A physical therapy evaluation was performed through an evaluation form deve loped by the authors and the Modified Barthel Index. The rating consisted of identification, pulmonary evaluation, calf circumference (CP) and performance the Timed Up and Go test (TUG). The data was collected at a long permanence institution for older adults, located in the interior of Goiás, with a sample of 40 older individuals. Results: The association between inspiratory muscle strength, CP, TUG test, Barthel index, PI max, PE max and age, correlate the reduction of muscle strength with lower level of functional capacity in older adults, even more significant in sex male, with less time to perform the TUG test, compared to the female. Conclusion: Is suggested a correlation between the level of functional and pulmonary capacity of older people, demonstrating the importance of the association of respiratory function training associated to physical exercise.(AU)

Prevalencia y determinantes de depresión en estudiantes de medicina, Honduras, noviembre, 2017 depresión en estudiantes de medicina / Prevalence and determinants of depression in medicine students, Honduras, november, 2017

INTRODUCCIÓN: el trastorno depresivo mayor se define por episodios determinados de al menos dos semanas de duración, que implican cambios claros en el afecto, cognición, funciones neurovegetativas, anhedonia, fatiga, entre otros. En Honduras, un 13.2% de la población se encuentra afectada; sin embargo, no hay estudios en depresión enfocado en estudiantes de medicina. MATERIALES Y MÉTODOS: se realizó un estudio observacional de alcance descriptivo, cuantitativo, transversal; muestreo no probabilístico por conveniencia. Participaron 380 estudiantes de medicina de la Universidad Nacional Autónoma de Honduras de una población de 7,700. Se empleo el Cuestionario de Salud del Paciente 9 (PHQ-9) para diagnóstico de depresión y se elaboró un cuestionario con 38 preguntas para obtener los determinantes asociados. Se realizó el análisis estadístico en SPSS v23 y se emplearon medidas de tendencia central y análisis de frecuencias. Se contemplaron las recomendaciones de la declaración de Helsinki. RESULTADOS Y DISCUSIÓN: el 31.57% presenta depresión mayor o menor. De ellos, se debería considerar el tratamiento en un 55% y aplicarse en un 19.5%. El 93.7% declaró que la carrera les generaba algún grado de estrés por la carga académica y exigencias. Además, un 14.8% expresó que ser funcionales en sus hogares, trabajos o en relaciones interpersonales es muy difícil o extremadamente difícil. Finalmente, un 11.90% de los encuestados tiene pensamientos de muerte o de autoagresiones en más de la mitad de los días o en casi todos los días.

INTRODUCTION: major depressive disorder is defined by certain episodes of at least two weeks of duration, which involve clear changes in affect, cognition, neuro-vegetative functions, anhedonia, fatigue, among others. In Honduras, 13.2% of the population is affected; however, there are no studies in depression focused on medical students. MATERIALS AND METHODS: this is a study with a descriptive scope, quantitative approach, cross-sectional; nonprobabilistic sampling. 380 medical students from the National Autonomous University of Honduras participated from a population of 7,700. The Patient Health Questionnaire 9 (PHQ-9) was used to diagnose depression and a questionnaire with 38 questions was prepared to obtain the associated determinants. Statistical analysis was performed in SPSS v23 and measures of central tendency and frequency analysis were used. The recommendations of the Helsinki declaration were considered. RESULTS AND DISCUSSION: 31.57% have major or minor depression, in which a 55% should be considered for treatment and definitely applied in a 19.5% 93.7% declared that the career generated some degree of stress due to the academic load and demands. In addition, 14.8% expressed that being functional in their homes, work or interpersonal relationships is very difficult or extremely difficult. Finally, 11.90% of those surveyed have thoughts of death or self-harm on more than half of the days or on almost every day(AU)

Impacto da saúde na qualidade de vida e trabalho de docentes universitários de diferentes áreas de conhecimento / Impact of health on quality of life and quality of working life of university teachers from different areas of knowledge

Resumo O objetivo deste artigo é identificar o impacto da saúde na qualidade de vida (QV) e qualidade da vida profissional (QVT) de professores universitários. Estudo descritivo, transversal, que avaliou 284 professores universitários das áreas da saúde, biologia, agrarias, humanas e exatas. A avaliação ocorreu através da aplicação de um questionário sociodemográfico com questões relacionadas aos dados de saúde, o WHOQOL-bref para avaliar QV e o TQWL-42 para avaliar a qualidade da vida no trabalho (QVT). Verificou-se que os professores que praticam atividade física apresentaram melhor QV e QVT e relataram melhor qualidade de sono, além disso, elas eram menores em professores que usam medicação, que têm uma dieta pobre e têm menos atividades de lazer. Além disso, a idade foi associada a melhor QV. A qualidade de vida e qualidade de vida no trabalho sofrem impacto dos aspectos relacionados à saúde.

Abstract This study aimed to determine the impact of health on the quality of life (QoL) and quality of working life (QWL) of university teachers. A cross-sectional study was conducted with 284 teachersin the areas of health, sciences, human sciences, and agricultural sciences using a sociodemographic questionnaire containing health-related questions, the WHOQOL-bref, and TQWL-42. Results: the findings showed that teachers who practiced physical activity had better QoL,QWL, and sleep quality. Advanced age was also associated with better QoL.Furthermore, QoL and QWL were lower in teachers who used medications, had an imbalanced diet, and did not practice leisure activities. QoL and QWL are influenced by health-related factors.