RESUMO
OBJECTIVE: We have determined Coenzyme Q(10) (CoQ(10)) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ(10) supplementation on cells levels and clinical symptoms. METHODS: CoQ(10) was determined by high-performance liquid chromatography (HPLC). Ten patients were supplemented daily with 300 mg of CoQ(10) during 3 months. RESULTS: CoQ(10) were reduced in both cell models. Oral supplementation showed an improvement in clinical symptoms and restored levels. CONCLUSIONS: Patients with FM showed an important dysfunction in CoQ(10) levels and might benefit from oral supplementation.
Assuntos
Fibromialgia/sangue , Leucócitos Mononucleares/metabolismo , Ductos Salivares/patologia , Ubiquinona/análogos & derivados , Vitaminas/uso terapêutico , Adulto , Estudos de Casos e Controles , Suplementos Nutricionais , Fibromialgia/tratamento farmacológico , Fibromialgia/patologia , Humanos , Pessoa de Meia-Idade , Ductos Salivares/metabolismo , Resultado do Tratamento , Ubiquinona/deficiência , Ubiquinona/farmacocinética , Ubiquinona/uso terapêutico , Vitaminas/farmacocinéticaRESUMO
OBJECTIVE: [corrected] Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology, which affects predominantly women. Mitochondrial alteration could have a role in the pathophysilogical mechanisms of inflammatory conditions as FM and periodontitis. The aim of the present study was assay the relationship between both diseases and mitochondrial dysfunction. PATIENT AND METHODS: We study the presence of periodontitis in twelve patients diagnosed of FM and mitochondrial dysfunction described. The diagnosis of FM was established according to ACR criteria and clinical symptoms were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI). RESULTS: Only one patients of twelve included and agreed to participate in the study were diagnosed with periodontitis. CONCLUSIONS: Pending studies with larger numbers of patients, we can conclude that mitochondrial dysfunction in FM is a itself event not related with periodontitis. Periodontitis could be considered a exclusion criterion in all studies about mitochondrial dysfunction in patients. Key words:Peridontitis, fibromyalgia, mitocondrial dysfunction, oxidative stress.