RESUMO
Novel organic charge transfer complex, m-xylylenediaminium-bis (p-toluenesulfonate) monohydrate (XDPTS) have been synthesized and crystallized to the triclinic system with space group P-1 and the lattice parameters obtained are a=9.9265(7) Å, b=9.9676(6) Å, c=13.4948(10) Å, α=71.95(6)°, ß=77.02(6)°, γ=76.851(5)°. The synthesized complex structure was confirmed by IR, (1)H NMR and (13)C NMR spectral analysis. Pharmacology activities of charge transfer complex were evaluated through antimicrobial, DNA binding/cleavage, antioxidant and cytotoxicity studies. The results reveal that the compound shows good antimicrobial activity against various antibacterial and antifungal species. The DNA interaction indicated that the compound could interact with DNA through intercalation, which is further confirmed by viscosity measurements. The compound should have weak to moderate capacity of scavenging with DPPH, Hydroxyl and ABTS radicals. The cytotoxicity has been evaluated by MTT assay method against MCF-7 cancer cell line.
Assuntos
Anti-Infecciosos/síntese química , Antioxidantes/síntese química , Diaminas/química , Substâncias Intercalantes/síntese química , Xilenos/química , Anti-Infecciosos/farmacologia , Antioxidantes/farmacologia , Benzenossulfonatos/síntese química , Benzenossulfonatos/química , Benzenossulfonatos/toxicidade , Sobrevivência Celular/efeitos dos fármacos , Cristalografia por Raios X , DNA/química , DNA/metabolismo , Clivagem do DNA/efeitos dos fármacos , Diaminas/síntese química , Diaminas/toxicidade , Fungos/efeitos dos fármacos , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Humanos , Substâncias Intercalantes/toxicidade , Células MCF-7 , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Conformação Molecular , Viscosidade/efeitos dos fármacos , Xilenos/síntese química , Xilenos/toxicidadeRESUMO
We have developed an effective microwave assisted p-TsOH catalyzed synthesis of pyrido[2,3-a]carbazoles via a one pot reaction of ethanolamine and 1-chloro-2-formyl carbazoles. The structure has been characterized by spectroscopic methods. The electronic spectroscopic experimental evidence strongly showed that the compounds could interact with calf thymus DNA (CT-DNA) through intercalation with a binding constant value of 1.2-3.0×10(4)M(-)(1). All the compounds showed weak to moderate capacity of scavenging with DPPH. The cytotoxicity has been evaluated by MTT assay against MCF-7 cell line and compared with standard drug cisplatin.