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1.
Knee Surg Sports Traumatol Arthrosc ; 29(8): 2640-2647, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34085108

RESUMO

PURPOSE: Intra-articular pathologies, such as labral and chondral lesions, are common in patients with frozen shoulder. This study evaluated the correlations between the range of motion and labral and chondral lesions in patients with frozen shoulder and investigated their pathophysiologies. METHODS: In total, 125 individuals (53 men and 72 women) who underwent arthroscopic pan-capsular release between 2014 and 2020 were included in the study. The range of motion was measured using scapular fixation and true glenohumeral motion under general anaesthesia. The American Shoulder and Elbow Surgeons Shoulder score and the Shoulder Rating Scale score of the University of California, Los Angeles were used to compare intra-articular pathologies. RESULTS: More than 80% of patients with frozen shoulder had labral pathologies, and nearly half of them had chondral pathologies. Labral lesions extending to the anterior rim of the glenoid had a greater range of motion and the greatest total American Shoulder and Elbow Surgeons Shoulder score. More severe chondral lesions had a lesser range of motion, but presented the greatest function scores and the lowest strength scores according to the Shoulder Rating Scale of the University of California, Los Angeles. The pain scores of the American Shoulder and Elbow Surgeons Shoulder score and the Shoulder Rating Scale of the University of California, Los Angeles were not correlated with the degree of these pathologies. The traction force affected the labrum during true range of motion, and the compression force occurred on the articular cartilage during internal rotation at 90° of forward flexion during diagnostic arthroscopy. CONCLUSION: Labral and chondral lesions are common in patients with frozen shoulder. Adherence to the capsulolabral complex induced a limited range of motion and labral and chondral pathologies. Diagnostic arthroscopy with motion is an important method of reproducing the pathogenesis of intra-articular structures for patients with frozen shoulder. LEVEL OF EVIDENCE: Level III.


Assuntos
Bursite , Articulação do Ombro , Artroscopia , Bursite/cirurgia , Feminino , Humanos , Cápsula Articular/cirurgia , Masculino , Amplitude de Movimento Articular , Articulação do Ombro/cirurgia , Resultado do Tratamento
3.
BMC Musculoskelet Disord ; 21(1): 761, 2020 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-33213419

RESUMO

BACKGROUND: Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorders such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis and oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for articular fractures accompanied by joint hemorrhage. Although joint hemorrhage has negative effects on the articular cartilage, there is no consensus on whether a reduction in joint hemorrhage would effectively prevent articular cartilage degeneration. The purpose of this study was to investigate the effect of joint hemorrhage combined with joint immobilization on articular cartilage degeneration in a rat immobilized knee model. METHODS: The knee joints of adult male rats were immobilized at the flexion using an internal fixator from 3 days to 8 weeks. The rats were randomly divided into the following groups: immobilized blood injection (Im-B) and immobilized-normal saline injection (Im-NS) groups. The cartilage was evaluated in two areas (contact and non-contact areas). The cartilage was used to assess chondrocyte count, Modified Mankin score, and cartilage thickness. The total RNA was extracted from the cartilage in both areas, and the expression of metalloproteinase (MMP)-8, MMP-13, interleukin (IL)-1ß, and tumor necrosis factor (TNF)-α was measured by quantitative real-time polymerase chain reaction. RESULTS: The number of chondrocytes in the Im-B group significantly decreased in both areas, compared with that in the Im-NS group. Modified Mankin score from 4 to 8 weeks of the Im-B group was significantly higher than that of the Im-NS group only in the contact area. The expression of MMP-8 and MMP-13 from 2 to 4 weeks and TNF-α from 2 to 8 weeks significantly increased in the Im-B group compared with those in the Im-NS group, but there was no significant difference in IL-1ß expression. CONCLUSIONS: The results showed that joint hemorrhage exacerbated immobilization-induced articular cartilage degeneration. Drainage of a joint hemorrhage or avoidance of loading may help prevent cartilage degeneration during joint immobilization with a hemorrhage.


Assuntos
Doenças das Cartilagens , Cartilagem Articular , Animais , Condrócitos , Hemartrose/etiologia , Articulação do Joelho , Masculino , Ratos
4.
JSES Int ; 4(3): 546-550, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32939483

RESUMO

BACKGROUND: Proximal humeral fractures are one of the most common fractures in adults. Some patients treated operatively have restriction in range of motion (ROM) after surgery. This study aimed to evaluate arthroscopic pancapsular release in patients with severe stiffness after treatment with intramedullary nailing for proximal humeral fractures. METHODS: This study included 12 patients (7 women and 5 men) who underwent arthroscopic pancapsular release in the beach-chair position between May 2015 and February 2018. Intraoperative findings were recorded, and ordinary (with scapulothoracic motion) and true (without scapulothoracic motion) glenohumeral ROMs were measured with a goniometer. The American Shoulder and Elbow Surgeons shoulder score, Shoulder Rating Scale score of the University of California, Los Angeles scoring system, and Constant score were compared before and after the release. The Wilcoxon signed rank and Mann-Whitney U tests were used to analyze data. RESULTS: The average age of the patients was 65.1 years (standard deviation, 9.5 years), and the mean follow-up period after the release was 30.6 months (standard deviation, 11.7 months). All ROMs on the affected side after surgery were significantly greater than those before surgery in all directions. However, ROMs in forward flexion, lateral elevation, and external rotation with the arm at the side and at 90° of forward flexion on the affected side postoperatively were significantly lower than those on the unaffected side. All scores were significantly greater after surgery than before surgery. CONCLUSION: Arthroscopic pancapsular release is effective for patients with proximal humeral fractures treated with intramedullary nailing.

5.
J Orthop Surg Res ; 15(1): 166, 2020 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-32370793

RESUMO

BACKGROUND: Conservative treatments for osteoporotic vertebral fractures (OVFs) have not been standardized, and criteria for determining bone union have not been established. To determine bone union, we have adopted a cutoff value of 1.0 mm for vertebral mobility (V-mobility), defined as the difference in anterior vertebral height (Ha) between lateral radiographs taken in weight-bearing and non-weight-bearing positions. The present study aimed to investigate the usefulness of V-mobility for determining bone union and predicting bone union at 6 months after OVF onset. METHODS: The study included 54 acute OVFs from T11 to L3 in 53 patients (12 males, 41 females; mean age 82 years; age range 55-97 years) who were hospitalized at ≤ 3 weeks after OVF onset. Vertebral deformity (V-deformity) and V-mobility were evaluated in accordance with Ha on lateral radiographs taken in the sitting position (SIT), lateral decubitus position (DEC), and supine position (SUP). OVFs showing V-mobility of ≤ 1.0 mm between SIT and DEC radiographs and no intravertebral cleft on DEC radiograph were defined as semi-union, while those showing V-mobility of ≤ 1.0 mm between SIT and SUP radiographs and no intravertebral cleft on SUP radiograph were defined as bone union. We calculated the bone union rates including semi-unions associated with V-mobility cutoff values of 1.0 mm, 1.5 mm, and 2.0 mm and estimated cutoff values for V-mobility at 5 weeks after OVF onset to predict bone union at 6 months after OVF onset. RESULTS: The cumulative number of bone unions including semi-unions was more influenced by the different V-mobility cutoff values in Ha for determining bone union in the earlier period compared with the later period in the time course of OVF. Receiver-operating characteristic curve analyses revealed that V-mobility cutoff value of 2.1 mm in Ha between SIT and DEC radiographs at 5 weeks after OVF had moderate accuracy for predicting bone union including semi-union at 6 months after OVF. The mean V-deformity value on SIT radiographs did not progress significantly. CONCLUSION: V-mobility in the early stage after OVF can predict bone union at 6 months after OVF and is a useful quantitative indicator for determining bone union.


Assuntos
Consolidação da Fratura/fisiologia , Fraturas por Osteoporose/diagnóstico por imagem , Amplitude de Movimento Articular/fisiologia , Fraturas da Coluna Vertebral/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Tratamento Conservador/métodos , Tratamento Conservador/tendências , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Limitação da Mobilidade , Fraturas por Osteoporose/terapia , Valor Preditivo dos Testes , Fraturas da Coluna Vertebral/terapia
6.
J Shoulder Elbow Surg ; 29(9): 1836-1842, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32414610

RESUMO

BACKGROUND: A thickened joint capsule is believed to be one of the most specific manifestations of and the primary restraint against range of motion (ROM) in frozen shoulders. The purpose of this study was to evaluate the relationship among ROMs under general anesthesia before surgery and the effects of each joint capsular release on ROM. METHODS: ROM was measured using a goniometer with scapular fixation. Arthroscopic pan-capsular release was performed with the patient in the beach-chair position in the following order: (1) rotator interval, (2) coracohumeral ligament, (3) superior capsule, (4) middle glenohumeral ligament, (5) anterior inferior glenohumeral ligament, and (6) posterior inferior glenohumeral ligament. ROMs in forward flexion (FF), lateral elevation (LE), external rotation with the arm at the side (ER1), external rotation at 90° of LE (ER2), internal rotation at 90° of LE (IR2), horizontal flexion, external rotation at 90° of FF (ER3), and internal rotation at 90° of FF (IR3) were evaluated before and after each release. RESULTS: A total of 32 consecutive shoulders were included. After each capsular release, the ROM recovered; the final ROM was significantly greater on the affected side than on the unaffected side. Significant correlations were found between FF and LE, FF and ER1, ER1 and ER2, ER1 and ER3, ER2 and ER3, and IR2 and IR3 on both sides, regardless of surgery. CONCLUSION: Each segment of the joint capsule affected ROM in all directions, supporting the need for whole-joint capsular release; ROM was significantly greater on the affected side than on the unaffected side after surgery.


Assuntos
Bursite/cirurgia , Liberação da Cápsula Articular , Amplitude de Movimento Articular/fisiologia , Articulação do Ombro/cirurgia , Artroscopia , Bursite/fisiopatologia , Humanos , Ligamentos Articulares/fisiopatologia , Ligamentos Articulares/cirurgia , Estudos Prospectivos , Rotação , Articulação do Ombro/fisiopatologia
7.
J Shoulder Elbow Surg ; 29(9): 1884-1891, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32279986

RESUMO

BACKGROUND: The etiology of frozen shoulder (FS) remains uncertain. Advanced glycation end-products (AGEs) cause the cross-linking and stabilization of collagen and are increased in FS. The purpose of this study was to elucidate the pathogenesis of FS by evaluating the receptor of AGE (RAGE)-dependent pathways. METHODS: Tissue samples of the coracohumeral ligament (CHL) and anterior inferior glenohumeral ligament (IGHL) were collected from 33 patients with FS, with severe stiffness, and 25 with rotator cuff tears (RCTs) as controls. Gene expression levels of RAGE, high-mobility group box 1 (HMGB1), Toll-like receptor 2 (TLR2), TLR4, nuclear factor-kappa B (NF-kB), and cytokines were evaluated using a quantitative real-time polymerase chain reaction. The immunoreactivities of carboxymethyllysine (CML), pentosidine, and RAGE were also evaluated. CML and pentosidine were further evaluated using high-performance liquid chromatography. RESULTS: Gene expression levels of RAGE, HMGB1, TLR2, TLR4, and NF-kB were significantly greater in the CHLs and IGHLs from the FS group than in those from the RCT group. Immunoreactivities of RAGE and CML were stronger in the CHLs and IGHLs from the FS group than in those from the RCT group. Pentosidine was weakly immunostained in the CHLs and IGHLs from the FS group. CML using high-performance liquid chromatography was significantly greater in the CHLs and IGHLs from the FS group than in those from the RCT group. CONCLUSIONS: AGEs and HMGB1 might play important roles in the pathogenesis of FS by binding to RAGE and activating NF-kB signaling pathways. Suppression of these pathways could be a treatment option for FS.


Assuntos
Bursite/metabolismo , Ligamentos Articulares/metabolismo , NF-kappa B/metabolismo , Receptor para Produtos Finais de Glicação Avançada/metabolismo , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Expressão Gênica , Proteína HMGB1/genética , Proteína HMGB1/metabolismo , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , NF-kappa B/genética , Reação em Cadeia da Polimerase em Tempo Real , Receptor para Produtos Finais de Glicação Avançada/genética , Estudos Retrospectivos , Transdução de Sinais , Receptor 2 Toll-Like/genética , Receptor 2 Toll-Like/metabolismo , Receptor 4 Toll-Like/genética , Receptor 4 Toll-Like/metabolismo
8.
J Shoulder Elbow Surg ; 29(1): 139-145, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31521523

RESUMO

BACKGROUND: Evidence is scarce concerning the relationship of physical dysfunction of the trunk and lower extremities with elbow and shoulder pain in young baseball players. This study aimed to examine the association of joint flexibility of the trunk and lower extremities and dynamic postural control with elbow and shoulder pain among elite young baseball players. METHODS: We analyzed baseball players (aged 9-12 years) who participated in the National Junior Sports Clubs Baseball Festival. Range of motion in external rotation and internal rotation (IR) of the hip, as well as the finger-to-floor distance and heel-to-buttock distance, was measured. The straight-leg-raise test was also conducted. Dynamic postural control was evaluated using the Star Excursion Balance Test. Multivariable logistic regression analyses were conducted to examine the association of physical function with the elbow or shoulder pain incidence. RESULTS: Of 210 players surveyed, 177 without elbow or shoulder pain were included in the analysis. Of the participants, 16 (9.0%) reported having elbow or shoulder pain during the tournament. Participants with the incidence of elbow or shoulder pain had a significant restriction in hip IR of the stride leg compared with those without pain (35.8° vs. 43.7°, P = .022). There were no significant associations of other joint flexibilities and the Star Excursion Balance Test with elbow or shoulder pain. CONCLUSION: Decreased hip IR range of motion of the stride leg was significantly associated with the elbow or shoulder pain incidence. Players, coaches, and clinicians should consider the physical function of the trunk and lower extremities for the prevention of elbow and shoulder pain.


Assuntos
Beisebol/lesões , Articulação do Quadril/fisiologia , Dor Musculoesquelética/epidemiologia , Rotação , Dor de Ombro/epidemiologia , Traumatismos em Atletas/epidemiologia , Estudos de Casos e Controles , Criança , Cotovelo , Humanos , Incidência , Masculino , Equilíbrio Postural , Amplitude de Movimento Articular
9.
Tohoku J Exp Med ; 249(4): 249-254, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31839627

RESUMO

Verbal or physical abuse from coaches has negative effects on young athletes, and the parents of athletes also have an influence on the sports environment. It is therefore important to understand parents' attitudes towards abuse against their children from the coaches. This study aimed to elucidate the characteristics of parents who accept the infliction of verbal or physical abuse on their children from coaches of youth sports teams. A cross-sectional study using self-report questionnaires was conducted with parents of young athletes (n = 6,493). Multivariate logistic regression models were used to assess the factors associated with parents' acceptability of verbal or physical abuse against their children. The proportion of parents who were accepting of verbal or physical abuse was 21.5%. Acceptability of verbal or physical abuse was significantly associated with male (odds ratio: 1.67, 95% confidence interval: 1.43-1.95), younger age (1.24, 1.09-1.41), lower educational attainment (1.32, 1.17-1.50), smoking habits (1.42, 1.23-1.63), experience of playing on a team with high levels of competition during their junior or high school days (1.31, 1.15-1.50), and experience of verbal and physical abuse by their own former coaches (3.59, 3.03-4.26 and 1.17, 1.02-1.35). About 58% and 28% of parents had experienced verbal and physical abuse from their own former coaches, and parents who had experienced verbal abuse themselves were most likely to be accepting of verbal or physical abuse towards their children. Educating parents is considered to be important for preventing and eradicating abuse against young athletes.


Assuntos
Maus-Tratos Infantis/psicologia , Tutoria , Pais/psicologia , Esportes Juvenis , Adulto , Criança , Intervalos de Confiança , Feminino , Humanos , Masculino , Razão de Chances
11.
J Orthop Sci ; 24(2): 361-367, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30497788

RESUMO

BACKGROUND: Because the relationship between coaches and athletes is unequal, verbal and physical abuse remains a common problem among sports coaches. We aimed to elucidate the characteristics of baseball coaches who verbally/physically abuse young baseball players. METHODS: A cross-sectional study was conducted on youth sports team coaches in Miyagi prefecture, Japan (n = 380), using a self-reported questionnaire. Multivariate logistic regression models were used for the analyses, evaluating the following variables: sex, age, educational level, smoking habits, years of coaching, level of baseball-playing experience, personal experience with verbal/physical abuse by former coaches, satisfaction with athletes' attitudes, number of athletes on the team, team competition level, awareness of the recommendations of the Japanese Society of Clinical Sports Medicine, limitations in the total pitch count, difficulty in coaching in other positions, number of games per year, and acceptance of former verbal/physical abuse. RESULTS: The prevalence of verbal/physical abuse toward young athletes was 74.5% (n = 283) and 6.6% (n = 25), respectively. Verbal abuse was significantly associated with personal experience of verbal abuse by former coaches (odds ratio [OR]: 2.00, 95% confidence interval [95% CI]: 1.04-3.85), and acceptance of verbal/physical abuse (OR: 2.61, 95% CI: 1.34-5.10). Physical abuse was significantly associated with greater than 10 years of coaching experience (OR: 7.16, 95% CI: 1.36-37.78), personal experience with physical abuse by former coaches (OR: 4.25, 95% CI: 1.23-14.70), and acceptance of verbal/physical abuse (OR: 3.85, 95% CI: 1.51-9.84). CONCLUSIONS: Coaches' experiences with verbal/physical abuse by former coaches negatively affected young athletes. Breaking this cycle is necessary to keep athletes active and interested in playing baseball. LEVEL OF EVIDENCE: Level III.


Assuntos
Atletas/psicologia , Beisebol/psicologia , Tutoria/ética , Abuso Físico/estatística & dados numéricos , Inquéritos e Questionários , Adolescente , Beisebol/fisiologia , Estudos Transversais , Feminino , Humanos , Incidência , Relações Interpessoais , Japão , Modelos Logísticos , Masculino , Tutoria/métodos , Análise Multivariada , Avaliação das Necessidades , Fatores de Risco , Autorrelato , Estresse Psicológico , Adulto Jovem
12.
Knee Surg Sports Traumatol Arthrosc ; 27(3): 985-990, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30194468

RESUMO

PURPOSE: Considerable research has focused on shoulder and elbow injuries among baseball players; however, although lumbar spine and knee injuries are commonly experienced, they are less frequently studied. During common motions in baseball, such as throwing, hitting, and running, energy is transferred from the lower extremities through the lower back to the upper body. Lower extremity pain, as well as lower back pain (LBP), can disrupt the kinematic chain, and it is important to understand the association between lower extremity complaints and LBP. The purpose of this study was to elucidate the association between knee pain and LBP among young baseball players. METHODS: A cross-sectional study was conducted with young baseball players (aged 6-15 years, n = 1,609) using a self-reported questionnaire. Multivariate logistic regression models were used for analyses. Variables considered in the models were sex, age, body mass index, team levels, number of days of training per week, number of hours in practice per day on weekdays and weekend, frequency of participation in games, practice intensity, and player position. RESULTS: The point prevalence of LBP and knee pain was 8.4% and 13.1%, respectively. Knee pain was significantly associated with LBP. Using the absence of knee pain as a reference, the adjusted odds ratio (95% confidence interval) for LBP was 5.83 (3.93-8.65) (p < 0.001) in the presence of knee pain. CONCLUSIONS: Knee pain was associated with LBP among young baseball players. Clinicians should pay attention to knee complaints to prevent and treat LBP among young baseball players. LEVEL OF EVIDENCE: III.


Assuntos
Artralgia/epidemiologia , Beisebol , Articulação do Joelho/fisiopatologia , Dor Lombar/epidemiologia , Adolescente , Artralgia/fisiopatologia , Criança , Estudos Transversais , Feminino , Humanos , Japão/epidemiologia , Masculino , Prevalência , Inquéritos e Questionários
13.
J Shoulder Elbow Surg ; 27(9): 1629-1635, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30054242

RESUMO

BACKGROUND: The effect of lifestyle factors on elbow or shoulder pain in young baseball players remains unclear. This study examined the association of game playing and television viewing with elbow or shoulder pain among elite young baseball players. METHODS: Study participants were young baseball players (age, 9-12 years) who participated in the National Junior Sports Clubs Baseball Festival in 2017. The national tournament invited 16 teams (totaling 210 players) selected based on the results of the regional qualifying tournaments. Self-reported questionnaires were mailed to all players before the tournament. Multiple logistic regression analyses were used to assess the association of video game playing and television viewing behavior with elbow or shoulder pain. RESULTS: Among the 210 players polled, 200 male players were included in the analysis. The prevalence of elbow or shoulder pain was 30.0%. Playing video games for ≥3 hours/day was significantly associated with elbow or shoulder pain vs. spending <1 hour/day playing video games (odds ratio, 5.59; 95% confidence interval, 1.44-21.64; P = .013). The amount of time spent watching television was not significantly associated with the prevalence of elbow or shoulder pain. CONCLUSIONS: Playing video games for ≥3 hours/day was associated with elbow or shoulder pain among elite young male baseball players. These findings highlight the effect of lifestyle on elbow and shoulder pain and should be taken into consideration by players, coaches, parents, and clinicians for the prevention of elbow and shoulder pain.


Assuntos
Artralgia/epidemiologia , Beisebol , Articulação do Cotovelo , Dor de Ombro/epidemiologia , Jogos de Vídeo/efeitos adversos , Criança , Humanos , Masculino , Televisão , Fatores de Tempo
14.
J Shoulder Elbow Surg ; 27(10): 1770-1778, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29784595

RESUMO

BACKGROUND: The etiology of frozen shoulder (FS) is unclear. Accordingly, this study used a label-free quantitative shotgun proteomic approach to elucidate the pathogenesis of FS based on protein expression levels. METHODS: Tissue samples from the rotator interval (RI), middle glenohumeral ligament (MGHL), and anterior-inferior glenohumeral ligament (IGHL) were collected from 12 FSs with severe stiffness and 7 shoulders with a rotator cuff tear (RCT) as controls. Protein mixtures were digested and analyzed by nano-liquid chromatography/electrospray ionization-tandem mass spectrometry. Relative protein expression levels were calculated by the signal intensity of identified peptide ions on mass spectra. Differentially expressed proteins between FS and RCT samples were evaluated by a gene enrichment analysis using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. RESULTS: We identified 1594 proteins, 1358 of which were expressed in all 6 tissue groups. We detected more upregulated proteins in the upper (RI and MGHL) FS groups and the lower (IGHL) RCT group than in the comparative groups, respectively. Various proteins with functions in tissue repair, collagen metabolism and fibrillation, cell-cell and cell-matrix adhesion, blood coagulation, and the immune response were expressed more highly in the RI and MGHL FS groups than in the RCT group. Proteins with functions in phagocytosis, glutathione metabolism, retinoid metabolism, and cholesterol metabolism were expressed more highly in the IGHL RCT group than in the FS group. CONCLUSIONS: The pathophysiology of FS differs between the upper and lower parts of the joint capsule. Different treatment strategies for FS may be appropriate, depending on the location.


Assuntos
Bursite/metabolismo , Cápsula Articular/metabolismo , Ligamentos Articulares/metabolismo , Lesões do Manguito Rotador/metabolismo , Adulto , Idoso , Coagulação Sanguínea/fisiologia , Bursite/genética , Adesão Celular/fisiologia , Colesterol/metabolismo , Colágeno/metabolismo , Feminino , Glutationa/metabolismo , Humanos , Imunidade/fisiologia , Cápsula Articular/patologia , Masculino , Pessoa de Meia-Idade , Fagocitose/fisiologia , Proteogenômica , Proteoma , Retinoides/metabolismo , Lesões do Manguito Rotador/genética , Regulação para Cima
15.
Ultrasound Med Biol ; 44(6): 1244-1256, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29573888

RESUMO

The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. Unilateral knee joints were immobilized in two groups of rats (n = 6/period/group). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d, 5 d/wk, using an existing LIPUS device (LIPUS group, 1.5-MHz frequency, 1.0-kHz repetition cycle, 200-µs burst width and 30-mW/cm2 power output) until endpoints (2, 4 or 6 wk). In the control group, general anesthesia alone was administered in the same manner as in the other group. The variables compared between the groups included joint angles; histologic, histomorphometric and immunohistochemical analyses; quantitative reverse transcription polymerase chain reactions; and tissue elasticity. LIPUS had a preventive effect on joint stiffness, resulting in decreased adhesion, fibrosis and inflammation and hypoxic response after joint immobilization.


Assuntos
Artropatias/prevenção & controle , Articulação do Joelho , Terapia por Ultrassom/métodos , Ondas Ultrassônicas , Animais , Modelos Animais de Doenças , Masculino , Ratos , Ratos Sprague-Dawley
16.
Tohoku J Exp Med ; 244(1): 15-24, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29311489

RESUMO

Rotator cuff tears (RCTs) are a common shoulder problem in the elderly that can lead to both muscle atrophy and fatty infiltration due to less physical load. Satellite cells, quiescent cells under the basal lamina of skeletal muscle fibers, play a major role in muscle regeneration. However, the myogenic potency of human satellite cells in muscles with fatty infiltration is unclear due to the difficulty in isolating from small samples, and the mechanism of the progression of fatty infiltration has not been elucidated. The purpose of this study was to analyze the population of myogenic and adipogenic cells in disused supraspinatus (SSP) and intact subscapularis (SSC) muscles of the RCTs from the same patients using fluorescence-activated cell sorting. The microstructure of the muscle with fatty infiltration was observed as a whole mount condition under multi-photon microscopy. Myogenic differentiation potential and gene expression were evaluated in satellite cells. The results showed that the SSP muscle with greater fatty infiltration surrounded by collagen fibers compared with the SSC muscle under multi-photon microscopy. A positive correlation was observed between the ratio of muscle volume to fat volume and the ratio of myogenic precursor to adipogenic precursor. Although no difference was observed in the myogenic potential between the two groups in cell culture, satellite cells in the disused SSP muscle showed higher intrinsic myogenic gene expression than those in the intact SSC muscle. Our results indicate that satellite cells from the disused SSP retain sufficient potential of muscle growth despite the fatty infiltration.


Assuntos
Tecido Adiposo/patologia , Desenvolvimento Muscular , Lesões do Manguito Rotador/patologia , Manguito Rotador/patologia , Células Satélites de Músculo Esquelético/patologia , Adipogenia , Idoso , Separação Celular , Feminino , Citometria de Fluxo , Perfilação da Expressão Gênica , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Fibras Musculares Esqueléticas/metabolismo , Atrofia Muscular/patologia , Lesões do Manguito Rotador/genética , Células Satélites de Músculo Esquelético/metabolismo
17.
Knee Surg Sports Traumatol Arthrosc ; 26(7): 1927-1935, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27771737

RESUMO

PURPOSE: Serious arm injuries in youth baseball players have been increasing. Though a breakage in the kinetic chain could affect arm injuries, an association between arm injuries and insufficient support of the trunk and lower extremities is not well understood. The purpose of this study was to investigate the association of low back and knee pain with elbow and/or shoulder complaints among youth baseball players. METHODS: A self-administered questionnaire and document informed consent were mailed to youth athletes belonging to the Miyagi Amateur Sports Association. Multiple logistic regression analysis was used to examine the association of low back and knee pain with elbow and/or shoulder pain at the time of the questionnaire. Variables considered in the models were as follows: sex, age, BMI, years of athletic experience, position, team level, the amount of practice, participating day in team practice and game per week, frequency of participation in games, and practice intensity. RESULTS: The final study population was comprised 1582 youth baseball players (aged 6-15 years old, male 95.6 %) who had responded to the questionnaire. A total of 24.8 % (n = 381) had elbow and/or shoulder pain, whereas 8.5 % (n = 130) had low back pain and 13.1 % (n = 201) had knee pain. The prevalence of elbow and/or shoulder pain with concomitant low back and knee pain was 61.2 % (n = 82) and 51.9 % (n = 108) (p < 0.001), respectively. The presence of low back and knee pain was significantly associated with the prevalence of elbow and/or shoulder pain among youth baseball players [adjusted odds ratio (ORs): 4.31, 95 % confidence interval (95 % CI): 2.86-6.51, p < 0.001, and ORs: 2.92, 95 % CI: 2.09-4.09, p < 0.001, respectively]. For other variables, older age (10- and 11-year old: ORs: 1.73, 95 % CI 1.10-2.73, p = 0.018; 12-15 year old: ORs: 1.62, 95 % CI: 1.18-2.58, p = 0.006), pitcher (ORs: 1.46, 95 % CI: 1.10-1.94, p = 0.009), catcher (ORs: 1.69, 95 % CI: 1.24-2.31, p = 0.001,), and practice intensity (ORs: 1.58, 95 % CI: 1.22-2.06, p = 0.001) were significantly associated with elbow and/or shoulder pain. CONCLUSION: Both low back and knee pain were significantly associated with elbow and/or shoulder pain in youth baseball players. Clinicians should check the complaints of the trunk and lower extremities as well as those of the elbow and shoulder for preventing severe injuries in youth baseball players. Level of Evidence III.


Assuntos
Beisebol/lesões , Lesões no Cotovelo , Traumatismos do Joelho/epidemiologia , Dor Lombar/epidemiologia , Dor de Ombro/epidemiologia , Adolescente , Traumatismos do Braço/complicações , Traumatismos do Braço/epidemiologia , Atletas , Traumatismos em Atletas/complicações , Traumatismos em Atletas/epidemiologia , Criança , Estudos Transversais , Humanos , Japão/epidemiologia , Traumatismos do Joelho/complicações , Dor Lombar/complicações , Masculino , Fatores de Risco , Ombro , Dor de Ombro/complicações , Esportes
18.
J Orthop Sci ; 22(3): 442-446, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28118947

RESUMO

BACKGROUND: The Great East Japan Earthquake and devastating Tsunami hit hard everything on the northeastern coast of Japan. This study aimed to determine socio-psychological factors for "subjective shoulder pain" of the survivors at 2 years evaluated by a self-report questionnaire. METHODS: Between November 2012 to February 2013, survivors replied to the self-report questionnaire, and 2275 people consented to join this study. Living status was divided into 5 categories (1. same house as before the earthquake (reference group), 2. temporary small house, 3. apartment, 4. house of relatives or acquaintance, 5. new house) and economic hardship was divided into 4 categories (1. normal (reference group), 2. a little bit hard, 3. hard, 4. very hard). Gender, age, body mass index, living areas, smoking and drinking habits, complications of diabetes mellitus and cerebral stroke, working status, and walking time were considered as the confounding factors. Kessler Psychological Distress Scale of ≥10/24 and Athens Insomnia Scale of ≥6/24 points were defined as a presence of psychological distress and sleep disturbance, respectively. We used multiple logistic regression analysis to examine the association of shoulder pain with living environment, economic hardship, psychological distress, and sleep disturbance at 2 years after the earthquake. RESULTS: There were significant differences in the risk of having shoulder pain in those with "apartment" (OR = 1.74, 95% CI = 1.03-2.96), "house of relatives or acquaintance" (OR = 2.98, 95% CI = 1.42-6.25), economic hardship of "hard" (OR = 1.71, 95% CI = 1.08-2.7) and "very hard" (OR = 2.51, 95% CI = 1.47-4.29), and sleep disturbance (OR = 2.96, 95% CI = 2.05-4.27). CONCLUSIONS: Living status of "apartment" and "house of relatives or acquaintance", economic hardship of "hard" and "very hard", and "sleep disturbance" were significantly associated with shoulder pain.


Assuntos
Desastres , Terremotos , Dor de Ombro/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Estresse Psicológico/epidemiologia , Sobreviventes/estatística & dados numéricos , Tsunamis , Idoso , Custos e Análise de Custo , Estudos Transversais , Feminino , Humanos , Incidência , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/complicações , Traumatismo Múltiplo/economia , Traumatismo Múltiplo/epidemiologia , Pobreza , Estudos Retrospectivos , Autorrelato , Dor de Ombro/complicações , Dor de Ombro/economia , Transtornos do Sono-Vigília/economia , Transtornos do Sono-Vigília/etiologia , Estresse Psicológico/economia , Estresse Psicológico/etiologia , Inquéritos e Questionários
19.
Knee Surg Sports Traumatol Arthrosc ; 25(7): 2217-2224, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26860102

RESUMO

PURPOSE: This study proposed new magnetic resonance imaging (MRI) of haemodialysis shoulders (HDS) focusing on the changes of the rotator cuff, and rotator interval and risk factors for the development of HDS were examined. METHODS: Eighty-five shoulders in 72 patients with a chief complaint of shoulder pain during haemodialysis and at least 10 years of haemodialysis were included. They were classified into 5 groups based on the thickness of the rotator cuff and conditions of rotator interval. Clinical and radiological findings in each grade were examined, and risk factors for the development of HDS were evaluated. Arthroscopic surgeries were performed on 22 shoulders in 20 patients, and arthroscopic findings were also evaluated. RESULTS: Positive correlations for the development of HDS were observed in duration of haemodialysis, positive hepatitis C virus (HCV) infection, and previous haemodialysis-related orthopaedic surgery (P < 0.001, respectively). Strong correlations were observed between positive HCV and the progression of HDS (odds ratio 24.8, 95 % confidence interval 5.7-107.6). Arthroscopically, progression of the surrounding soft tissue degeneration was observed, and operative times were lengthened depending on the progression of MRI grading. CONCLUSION: A new MRI classification of HDS which may be helpful when considering arthroscopic surgeries has been proposed. Positive HCV infection was strongly associated with the progression of HDS on MRI. Conditions of the rotator interval and the rotator cuff based on the MRI classification should be examined when treating HDS patients. LEVEL OF EVIDENCE: III.


Assuntos
Amiloidose/classificação , Amiloidose/diagnóstico por imagem , Imageamento por Ressonância Magnética , Diálise Renal/efeitos adversos , Manguito Rotador/diagnóstico por imagem , Articulação do Ombro/diagnóstico por imagem , Amiloidose/etiologia , Artroscopia , Feminino , Hepatite C/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Radiografia , Estudos Retrospectivos , Fatores de Risco , Manguito Rotador/cirurgia , Articulação do Ombro/cirurgia , Dor de Ombro/etiologia , Dor de Ombro/cirurgia , Fatores de Tempo , Resultado do Tratamento
20.
J Shoulder Elbow Surg ; 26(2): 233-240, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27814944

RESUMO

BACKGROUND: Evaluation of range of motion (ROM) restriction before treatment of shoulder disorders is important for predicting the final functional outcomes. The purpose of this study was to investigate correlations of thickness of the coracohumeral ligament (CHL) and ROM restriction in patients with recurrent anterior glenohumeral instability. METHODS: Between January 2005 and March 2015, 181 shoulders (137 male and 44 female patients; mean age, 29.3 years) with recurrent anterior glenohumeral instability treated with an arthroscopic Bankart repair were enrolled in this study. We evaluated preoperative ROM, thickness of the CHL, and obliteration of the subcoracoid fat triangle on magnetic resonance arthrography. ROM measurements, including forward flexion (FF), external rotation with the arm at the side (ER), and hand behind the back (HBB), were made in a standing position. RESULTS: There were significant negative correlations between FF and age (P < .001) and between HBB and age (P < .001) but not between ER and age (P = .11). The thickness of the CHL significantly increased with age (P < .001). FF, ER, and HBB were significantly restricted in patients with obliteration compared with those without obliteration (P < .001, P = .004, P < .001, respectively). CONCLUSIONS: Obliteration of the subcoracoid fat triangle and the thickness of the CHL positively correlated with ROM restrictions, and these changes were greater with age in patients with recurrent anterior glenohumeral instability.


Assuntos
Instabilidade Articular/diagnóstico por imagem , Ligamentos Articulares/fisiopatologia , Articulação do Ombro/diagnóstico por imagem , Adolescente , Adulto , Fatores Etários , Artrografia , Estudos de Casos e Controles , Criança , Estudos de Coortes , Feminino , Humanos , Instabilidade Articular/fisiopatologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Recidiva , Estudos Retrospectivos , Articulação do Ombro/fisiopatologia , Adulto Jovem
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