RESUMO
BACKGROUND: Blastomycosis is an uncommon chronic granulomatosis caused by Blastomyces dermatitidis. We present a case with a skin localization that disclosed malignant corticoadenoma. CASE REPORT: A 32-year-old man consulted for inflammatory nodules of the face and lower limbs. The histological examination of a nodule biopsy was in favour of blastomycosis. Ketoconazole treatment was ineffective. Amphotericin B provided cure of the skin lesions. Search for extension disclosed a malignant corticoadrenoma. DISCUSSION: Blastomycosis is very rare in Morocco. The portal is usually the lung. Unique skin involvement is very exceptional. To our knowledge this is the first report of a blastomycosis-corticoadenoma association. The clinical situation may be alarming in immunodepressed subjects. Amphotericin B treatment is indicated.
Assuntos
Neoplasias do Córtex Suprarrenal/diagnóstico , Adenoma Adrenocortical/complicações , Adenoma Adrenocortical/diagnóstico , Blastomicose/complicações , Neoplasias do Córtex Suprarrenal/complicações , Adulto , Humanos , MasculinoRESUMO
Between 1980 and 1987, 12 systematic surveys were made on a population of 254,979 people, of whom 236,868 were actually examined (92.61%). 422 suspected cases were identified i.e. a global detection rate of 1.66% of which only 241 reported to Aïn-Chock Hospital for further tests (55%). Out of these 241 suspected cases, 217 proved as having leprosy, i.e. a 90% correlation between the clinical suspicion and the biological identification. The 181 suspected cases who never reported to the hospital and the 16 leprosy patients whom we lost sight of constitute as a whole 46.68% of the suspected cases first identified. This shows an obvious lack of coordination between the local Authority and the medical service. The 185 confirmed cases of leprosy are shown in the table below and compared with those of the Central Statistical Office.
Assuntos
Hanseníase/epidemiologia , Adolescente , Adulto , Criança , Feminino , Humanos , Incidência , Hanseníase Virchowiana/epidemiologia , Hanseníase Tuberculoide/epidemiologia , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Marrocos/epidemiologia , Vigilância da População , PrevalênciaAssuntos
Adenoma de Glândula Sudorípara/patologia , Neoplasias Cutâneas/patologia , Adulto , Braço , Humanos , Masculino , TóraxAssuntos
Sarcoma de Kaposi/imunologia , Feminino , HIV/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , MarrocosRESUMO
Ganglioneuroblastoma a transitional tumor of sympathetic origin has not yet been described as involving orbit. It is characterized by a mixture of cells ranging from primitive neuroblast to well differentiated ganglion cells within a neurofibromatous tissue. The prognosis is uncertain, as the tumor may either undergo maturation into a ganglioneuroma or may metastasize widely and rapidly as in neuroblastoma. We may postulate a relationship between ganglioneuroblastoma and Recklinghausen's neurofibromatosis in view of the development of the tumor in conjunction with the phacomatosis.
Assuntos
Ganglioneuroma/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Orbitárias/patologia , Transformação Celular Neoplásica/patologia , Pré-Escolar , Diagnóstico Diferencial , Ganglioneuroma/fisiopatologia , Ganglioneuroma/terapia , Humanos , Masculino , Neuroblastoma/patologia , Neuroblastoma/fisiopatologia , Neurofibromatose 1/patologia , Neoplasias Orbitárias/terapia , Prognóstico , Neoplasias Cutâneas/patologiaRESUMO
Cowden's disease is a phacomatosis (multiple hamartomas), which is a familial, hereditary, dominant autosomal affection presenting as typical buccolabial mucocutaneous lesions associated with digestive tract polyps. Differential diagnosis of the predominantly digestive form of the disease is polyposis. A new case of this rare disorder is reported, only 62 cases being documented in literature.