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1.
Int J Cardiol ; 407: 132075, 2024 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-38643801

RESUMO

BACKGROUND: Regarding the pathophysiology of renal infarction (RI), cardioembolic causes could have large proportion. However, there are notable variations in prevalence of atrial fibrillation (AF) among patients with RI across different studies, ranging from 17 to 65%. The primary objective of this study is to analyze the incidence of AF in patients with RI. METHODS: This nationwide retrospective cohort study enrolled 5200 patients with RI from the Korean National Institute of Health Services database spanning the years 2013 to 2019. The study accessed the AF incidence rate within 12 months in patients without a prior history of AF. Events occurring within 3 months of RI diagnosis were excluded to mitigate cases diagnosed during the initial screening or those with AF diagnoses that were potentially overlooked in the past. RESULTS: AF occurred in 19.1% of patients with RI over the entire period (median: 2.5 years, interquartile range 1.04-4.25 years). The majority of AF cases (16.1%) occured within the first year, resulting in an overall incidence rate of 7.0 per 100 person-years. Patients with newly developed AF were, on average, older than those who did not develop AF (64.1 vs. 57.3 years, P < 0.001). The independent predictors of AF were identified as age, male sex, higher body mass index, current smoking, ischemic heart disease, and heart failure. CONCLUSIONS: Physicians should consider the implementation of active rhythm monitoring for patients with RI to identify potential occurrence of subclinical AF, even if not initially diagnosed during the initial screening after RI diagnosis.


Assuntos
Fibrilação Atrial , Sistema de Registros , Humanos , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/complicações , Masculino , Feminino , Incidência , Estudos Retrospectivos , Pessoa de Meia-Idade , República da Coreia/epidemiologia , Idoso , Infarto/epidemiologia , Infarto/diagnóstico , Programas Nacionais de Saúde/estatística & dados numéricos , Estudos de Coortes , Nefropatias/epidemiologia , Nefropatias/diagnóstico , Adulto
2.
Korean J Intern Med ; 38(5): 692-703, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37648226

RESUMO

BACKGROUND/AIMS: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF). METHODS: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤ 40% undergoing ARNI treatment. The patients were divided into patients with newly diagnosed HF with ARNI treatment initiated within 6 months of diagnosis (de novo HF group) and those who were diagnosed or admitted for HF exacerbation for more than 6 months prior to initiation of ARNI treatment (prior HF group). The primary outcome was a composite of cardiovascular death and worsening HF, including hospitalization or an emergency visit for HF aggravation within 12 months. RESULTS: No significant differences in baseline characteristics were reported between the de novo and prior HF groups. The prior HF group was significantly associated with a higher primary outcome (23.9 vs. 9.4%) than the de novo HF group (adjusted hazard ratio 2.52, 95% confidence interval 1.06-5.96, p = 0.036), although on a higher initial dose. The de novo HF group showed better LVEF improvement after 1 year (12.0% vs 7.4%, p = 0.010). Further, the discontinuation rate of diuretics after 1 year was numerically higher in the de novo group than the prior HF group (34.4 vs 18.5%, p = 0.064). CONCLUSION: The de novo HF group had a lower risk of the primary composite outcome than the prior HF group in patients with reduced ejection fraction who were treated with ARNI.


Assuntos
Insuficiência Cardíaca , Neprilisina , Humanos , Volume Sistólico , Estudos Retrospectivos , Função Ventricular Esquerda , Resultado do Tratamento , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/tratamento farmacológico , Anti-Hipertensivos , Antivirais
3.
Korean J Radiol ; 11(1): 115-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20046502

RESUMO

A 38-year-old woman who had undergone pelvic lymphangioma resection two months previously presented with cough and dyspnea. Transthoracic echocardiography and CT demonstrated the presence of a mixed cystic/solid component tumor involving the inferior vena cava, heart and pulmonary artery. Complete resection of the cardiac tumor was performed and lymphangioma was confirmed based on histopathologic examination. To the best of our knowledge, this is the first report of lymphangiomatosis with cardiac and pelvic involvement in the published clinical literature.


Assuntos
Neoplasias Cardíacas/patologia , Linfangioma/patologia , Segunda Neoplasia Primária/patologia , Neoplasias Pélvicas/patologia , Artéria Pulmonar/patologia , Veia Cava Inferior/patologia , Adulto , Feminino , Neoplasias Cardíacas/diagnóstico , Humanos , Linfangioma/diagnóstico , Linfangioma/cirurgia , Invasividade Neoplásica , Segunda Neoplasia Primária/diagnóstico , Neoplasias Pélvicas/cirurgia
4.
J Cardiovasc Ultrasound ; 18(4): 148-50, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21253365

RESUMO

We describe a 72-year-old man who presented with left hemiparesis due to acute cerebral infarction in the right fronto-temporal lobe. Three months prior to admission, he was hospitalized for right hemiparesis due to the acute cerebral infarction in the left anterior cerebral artery territory. To investigate the cause of his recurrent embolic event, a chest computed tomography scan and echocardiography were performed, which revealed advanced lung cancer invading contiguously through the pulmonary veins to the right main pulmonary artery and left atrium. Tumor embolism is a rare cause of stroke, occurring with primary or metastatic neoplasms of the lung. Echocardiography is a useful tool in patients with cerebral embolic episodes.

5.
Catheter Cardiovasc Interv ; 73(6): 791-4, 2009 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-19301352

RESUMO

A retrograde approach through the collateral channels is considered to improve the success rate of percutaneous coronary intervention for coronary chronic total occlusion (CTO). Various kinds of strategies and techniques are required to improve the success rate of this novel approach. We describe a case in which a CTO was successfully recanalized by the retrograde approach, using a new anchoring balloon technique (double anchoring balloon technique) which enabled the successful balloon passage through the hard CTO lesion.


Assuntos
Angioplastia Coronária com Balão/métodos , Calcinose/terapia , Oclusão Coronária/terapia , Angioplastia Coronária com Balão/efeitos adversos , Angioplastia Coronária com Balão/instrumentação , Calcinose/diagnóstico por imagem , Calcinose/fisiopatologia , Doença Crônica , Circulação Colateral , Angiografia Coronária , Circulação Coronária , Oclusão Coronária/diagnóstico por imagem , Oclusão Coronária/fisiopatologia , Reestenose Coronária/etiologia , Reestenose Coronária/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Stents , Resultado do Tratamento
6.
Stem Cells ; 25(6): 1431-8, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17347495

RESUMO

Autologous mesenchymal stem cell (MSC) transplantation therapy for repair of myocardial injury has inherent limitations due to the poor viability of the stem cells after cell transplantation. Adhesion is a prerequisite for cell survival and also a key factor for the differentiation of MSCs. As a novel prosurvival modification strategy, we genetically engineered MSCs to overexpress tissue transglutaminase (tTG), with intention to enhance adhesion and ultimately cell survival after implantation. tTG-transfected MSCs (tTG-MSCs) showed a 2.7-fold and greater than a twofold increase of tTG expression and surface tTG activity, respectively, leading to a 20% increased adhesion of MSCs on fibronectin (Fn). Spreading and migration of tTG-MSCs were increased 4.75% and 2.52%, respectively. Adhesion of tTG-MSCs on cardiogel, a cardiac fibroblast-derived three-dimensional matrix, showed a 33.1% increase. Downregulation of tTG by transfection of small interfering RNA specific to the tTG resulted in markedly decreased adhesion and spread of MSCs on Fn or cardiogel. tTG-MSCs on Fn significantly increased phosphorylation of focal adhesion related kinases FAK, Src, and PI3K. tTG-MSCs showed significant retention in infarcted myocardium by forming a focal adhesion complex and developed into cardiac myocyte-like cells by the expression of cardiac-specific proteins. Transplantation of 1 x 10(6) MSCs transduced with tTG into the ischemic rat myocardium restored normalized systolic and diastolic cardiac function. tTG-MSCs further restored cardiac function of infarcted myocardium as compared with MSC transplantation alone. These findings suggested that tTG may play an important role in integrin-mediated adhesion of MSCs in implanted tissues. Disclosure of potential conflicts of interest is found at the end of this article.


Assuntos
Células da Medula Óssea/citologia , Proteínas de Ligação ao GTP/fisiologia , Integrinas/fisiologia , Células-Tronco Mesenquimais/citologia , Transglutaminases/fisiologia , Animais , Células da Medula Óssea/metabolismo , Adesão Celular/genética , Movimento Celular/genética , Proliferação de Células , Sobrevivência Celular , Células Cultivadas , Proteínas de Ligação ao GTP/genética , Proteínas de Ligação ao GTP/metabolismo , Coração/fisiologia , Masculino , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/metabolismo , Proteína 2 Glutamina gama-Glutamiltransferase , Ratos , Ratos Sprague-Dawley , Transfecção , Transglutaminases/genética , Transglutaminases/metabolismo
7.
Heart Vessels ; 21(3): 195-8, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16715196

RESUMO

Noncompaction of the ventricular myocardium (NVM) is a rare cardiac abnormality of unknown etiology. The condition is characterized by prominent and excessive trabeculations in a ventricular wall segment, with deep intertrabecular spaces perfused from the ventricular cavity. Polycystic kidney diseases are characterized by the formation of multiple cysts in the kidneys and liver and, less frequently, in the pancreas. Cardiovascular abnormalities including hypertension, mitral valve prolapse, and intracranial aneurysms are also frequently recognized. However, polycystic kidney disease and isolated ventricular noncompaction have not previously been correlated. Here, we describe one case of isolated noncompaction of ventricular myocardium with polycystic kidney disease, coupled with a progressive worsening of heart failure. We confirmed these abnormalities using contrast echocardiography, abdominopelvic computed tomography, and cardiac magnetic resonance imaging.


Assuntos
Cardiomiopatias/epidemiologia , Cardiomiopatias/patologia , Ventrículos do Coração/patologia , Miocárdio/patologia , Doenças Renais Policísticas/epidemiologia , Doenças Renais Policísticas/patologia , Cardiomegalia/diagnóstico por imagem , Comorbidade , Cistos/diagnóstico por imagem , Cistos/epidemiologia , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Humanos , Hepatopatias/diagnóstico por imagem , Hepatopatias/epidemiologia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Ultrassonografia
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