RESUMO
The significance of neurospecific proteins in the diagnosis of neurotoxicity in patients with breast, lung, testicular, and ovarian cancer treated by taxane and cisplatin drugs was evaluated. The most pronounced increase in the content of these proteins and titers of autoantibodies to these proteins was observed in patients with clinical manifestations of neurotoxicity induced by cytostatics. A strong correlation was found between the concentration of myelin basic protein and cumulative dose of the drug (R=0.922; p<0.0001). These data suggest that myelin basic protein and gliofibrillar acid protein can be used as markers in the diagnosis and monitoring of antitumor drug neurotoxicity.
Assuntos
Antineoplásicos/farmacologia , Neurônios/efeitos dos fármacos , Autoanticorpos/biossíntese , Neoplasias da Mama/tratamento farmacológico , Cisplatino/farmacologia , Relação Dose-Resposta a Droga , Feminino , Proteína Glial Fibrilar Ácida/sangue , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Masculino , Proteína Básica da Mielina/sangue , Neurônios/metabolismo , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Testiculares/tratamento farmacológico , Fatores de TempoAssuntos
Síndromes Paraneoplásicas/diagnóstico , Humanos , Degeneração Paraneoplásica Cerebelar/classificação , Degeneração Paraneoplásica Cerebelar/diagnóstico , Polineuropatia Paraneoplásica/classificação , Polineuropatia Paraneoplásica/diagnóstico , Síndromes Paraneoplásicas/classificação , Doenças da Medula Espinal/classificação , Doenças da Medula Espinal/diagnósticoAssuntos
Lesões Encefálicas/complicações , Encéfalo/efeitos da radiação , Encefalomielite/etiologia , Leucoencefalite Hemorrágica Aguda/etiologia , Leucoencefalopatia Multifocal Progressiva/etiologia , Lesões por Radiação/complicações , Traumatismos da Medula Espinal/etiologia , Encéfalo/patologia , Humanos , Doses de Radiação , Radiação Ionizante , Traumatismos da Medula Espinal/patologiaRESUMO
A study was made of a possibility to use immunological methods (the leucocyte migration inhibition test, leukergia reaction, the test of the cold fixation of the complement with cerebral antigen) for the assessment of neurotoxic and neuroradiation effects in total therapeutic irradiation of man at a dose of 10 Gy with preceding polychemotherapy. A rapid development of agranulocytosis made cellular reactions impossible. The above effects could be assessed using humoral specific immunological reactions. A possible role of anticerebral antibodies in the pathogenesis of neurological disorders was discussed.