1.
Chem Commun (Camb)
; 58(5): 645-648, 2022 Jan 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34747956
RESUMO
Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system.