RESUMO
The experimental model of synchronous multiple primary malignant tumors (MPMT) was created. B16/F10 melanoma (0.5 ml of suspension diluted 1:20 in saline) and sarcoma 45 (0.5 million tumor cells in 0.5 ml saline) were simultaneously subcutaneously inoculated to male BALB/c nude mice. In the model of synchronous MPMT, the tumors appeared faster by 2.4 times and had greater volumes: melanoma by 2.2 times and sarcoma by 3.2 times; melanoma metastasized into sarcoma in 71.4% cases; the survival of mice with MPMT was lower. The altered dynamics of malignant growth in the MPMT model is based on the mutual influence of tumors, which results in the exchange of "structural information".
Assuntos
Neoplasias Pulmonares/patologia , Melanoma Experimental/patologia , Transplante de Neoplasias/métodos , Neoplasias Primárias Múltiplas/patologia , Doenças da Imunodeficiência Primária/patologia , Neoplasias Cutâneas/patologia , Animais , Linhagem Celular Tumoral , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/imunologia , Masculino , Melanoma Experimental/genética , Melanoma Experimental/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Nus , Neoplasias Primárias Múltiplas/genética , Neoplasias Primárias Múltiplas/imunologia , Doenças da Imunodeficiência Primária/genética , Doenças da Imunodeficiência Primária/imunologia , Ratos , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/imunologiaRESUMO
Experimental study of extracorporeal exposure of autoblood to red monochromatic photodiode radiation for improving antitumor efficiency of cyclophosphamide injected with autoblood was carried out on the model of sarcoma 45 cells ectopically transplanted to the lungs. Co-incubation of irradiated autoblood with cyclophosphamide and reinfusion of the blood to animals increased the antitumor efficiency of chemotherapy in animals with tumors.
Assuntos
Transfusão de Sangue Autóloga/métodos , Ciclofosfamida/uso terapêutico , Lasers Semicondutores/uso terapêutico , Fotoferese/métodos , Sarcoma/terapia , Animais , Antineoplásicos/administração & dosagem , Antineoplásicos/uso terapêutico , Terapia Combinada , Ciclofosfamida/administração & dosagem , Infusões Intravenosas , Terapia com Luz de Baixa Intensidade , Pulmão/efeitos dos fármacos , Pulmão/patologia , Masculino , Transplante de Neoplasias , Ratos , Sarcoma/patologia , Carga Tumoral/efeitos dos fármacosRESUMO
Effects of various physical factors of electromagnetic nature on the synthetic and phagocytic activities of neutrophils were studied in vitro on the blood of patients with breast cancer. We found that alternating magnetic field, low-intensity laser, photodiod radiation, and their combinations induced mobilization of blood neutrophil function.
Assuntos
Neoplasias da Mama/imunologia , Neutrófilos/efeitos da radiação , Estudos de Casos e Controles , Campos Eletromagnéticos , Feminino , Humanos , Neutrófilos/fisiologia , Fagocitose/efeitos da radiação , Radiação , Espectrometria de FluorescênciaRESUMO
Exposure of rats with Pliss lymphosarcoma to incoherent red light according to certain protocols creates conditions preventing suppression of antitumor resistance, reducing the toxic effect of cyclophosphamide, and potentiating its antitumor effect.