RESUMO
Studies indicate a close relationship between Yersinia and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of Yersinia DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of Yersinia in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; p = 0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and Yersinia is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.
Assuntos
Doença de Crohn/microbiologia , Yersinia/isolamento & purificação , Yersinia/patogenicidade , Adolescente , Proteínas de Bactérias/genética , Estudos de Casos e Controles , Criança , DNA Bacteriano/genética , DNA Bacteriano/isolamento & purificação , Feminino , Genes Bacterianos , Humanos , Mucosa Intestinal/microbiologia , Masculino , Estudos Retrospectivos , Yersinia/genética , Yersinia enterocolitica/genética , Yersinia enterocolitica/isolamento & purificação , Yersinia enterocolitica/patogenicidade , Yersinia pseudotuberculosis/genética , Yersinia pseudotuberculosis/isolamento & purificação , Yersinia pseudotuberculosis/patogenicidade , Adulto JovemRESUMO
Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90%), ERG1 (5%), ETV1 (1%), ETV4 (1%), and FEV (1%). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.
Assuntos
Neoplasias Ósseas/genética , Cromossomos Humanos Par 22/genética , Cromossomos Humanos Par 7/genética , Sarcoma de Ewing/genética , Translocação Genética , Cariótipo Anormal , Biomarcadores Tumorais/metabolismo , Neoplasias Ósseas/patologia , Neoplasias Ósseas/terapia , Criança , Terapia Combinada , DNA de Neoplasias/análise , Intervalo Livre de Doença , Evolução Fatal , Feminino , Humanos , Hibridização in Situ Fluorescente , Lactente , Proteínas de Fusão Oncogênica/genética , Proteínas de Fusão Oncogênica/metabolismo , Sarcoma de Ewing/patologia , Sarcoma de Ewing/terapiaRESUMO
Ewing sarcoma (ES) is the second most common bone malignancy in children and adolescents. Together with primitive neuroectodermal tumors (PNET), ES comprises the PNET/ES family. Metastasis is present in about 25% of patients at diagnosis and is most commonly found in the lung and bones. Primary PNET/ES of the ovary has been reported in many adult cases; however, secondary occurrences are rare. Here we present the clinical course of a 13-year-old patient with metastatic ES to the ovary without involvement of any other sites. To our knowledge, this is the second reported pediatric case of metastatic ES to the ovary.
Assuntos
Neoplasias Ósseas/patologia , Neoplasias Ovarianas/secundário , Sarcoma de Ewing/secundário , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Ósseas/terapia , Terapia Combinada , Evolução Fatal , Feminino , Humanos , Procedimentos Ortopédicos , Neoplasias Ovarianas/terapia , Ovariectomia , Salpingectomia , Sarcoma de Ewing/terapiaRESUMO
Hematopoietic stem cell transplantation (HSCT) causes many complications including the development of graft-versus-host disease (GVHD). Pneumatosis intestinalis (PI), a rare side affect in patients with post-HSCT GVHD, is uncommonly seen in non-neonatal patients. In neonates, surgical intervention is common, yet in non-neonatal patients, medical management is advisable. We present four pediatric patients who post-HSCT developed GVHD and subsequently PI. Surgery was performed on one patient while the other three were successfully managed conservatively. Although PI is rare in this group of patients, clinicians should be aware of this post-HSCT complication to ensure early diagnosis and proper management.
Assuntos
Doença Enxerto-Hospedeiro/etiologia , Pneumatose Cistoide Intestinal/etiologia , Transplante de Células-Tronco/efeitos adversos , Transplante Homólogo , Adolescente , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Procedimentos Cirúrgicos do Sistema Digestório , Feminino , Doença Enxerto-Hospedeiro/diagnóstico , Doença Enxerto-Hospedeiro/terapia , Humanos , Lactente , Pneumatose Cistoide Intestinal/diagnóstico , Pneumatose Cistoide Intestinal/terapia , Complicações Pós-Operatórias , Resultado do TratamentoRESUMO
Fibrocartilaginous mesenchymoma is a rare osseous tumor that primarily arises in the long bones of children and adolescents. This lesion can grow quickly and reach a considerable size, despite its benign nature. It has proved challenging to diagnose and can be mistaken for a spectrum of benign and malignant bone tumors. The histological presentation of unique epiphyseal plate-like cartilage with destruction of the surrounding cortical bone and exhibition of dense fibrous stroma are important indicators for the diagnosis of fibrocartilaginous mesenchymoma. An 11-year-old boy presented with a left proximal humerus mass thought to be an aneurysmal bone cyst. The patient was lost to follow-up and came back 3 years later with massive growth of the lesion. Owing to the aggressive nature of the tumor, a left forequarter amputation was performed. Histological examination demonstrated numerous islands of cartilage with an exuberant spindle cell component characteristic of FCM. No distant metastases or local recurrences were identified at 2 years post-amputation. Because of the rapid growth of this lesion, it should be considered in the differential diagnosis of bone lesions in children and young adults.